Sudden Cardiac Death in Young Individuals: A Current Review of Evaluation, Screening and Prevention

Abbas, Ramsha; Abbas, Aiza; Khan, Talha Kamran; Sharjeel, Salal; Amanullah, Khadija; Irshad, Yusra

doi:10.14740/jocmr4823

Cited by 8 publications

(3 citation statements)

References 63 publications

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“…Reality accommodates this consequence in the sudden and unexpected deaths in the apparently healthy (from newborn through to adults) which have hitherto constituted a challenge for medical examiners, law enforcement officers, and society as a whole, 59 such as the "sudden cardiac deaths" that occur in young humans in spite of a "structurally normal" heart and negative toxicology analysis. 60 If the aging individuals are those who escape this sudden death due to the intense pathological response that underlies the fatality of prenatal disease processes as other sufferers die off from the womb and become rare after the first day of life are those who reduce this response promptly to levels that are so low that the recruitment of destructive cells into the blood fails to occur in them after birth, what must medicine observe? Such aging humans who die from the slow deterioration due to the extreme reduction of the pathological response that underlies disease processes must not suffer from cancer like the dying humans in whom destructive cells are recruited by cancer cells even in the face of malignant tumors and other factors to which the current paradigm attributes this suffering and evidence of such recruitment must not be found in their bone marrow and other blood-forming sites.…”

Section: Aging Individuals Escape Accelerated Deterioration and Suffe...mentioning

confidence: 99%

The Determination of a Verifiable Medical Research Paradigm

Ola¹

2023

Preprint

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Consistent models are crucial to engaging patients with treatment that terminate disease processes in recovery and we responded by developing a verifiable medical research paradigm which predicts the results that experimental models must yield if medicine will understand the mechanisms underlying disease phenomena. We found that the accelerated deterioration and organ damage in the suffering and dying is due to the recruitment of destructive cells into the blood in cancer and that, by avoiding this cancerous contribution to the blood, the aging die peacefully from the slow deterioration and frailty due to disease processes at very old age while remaining very mentally clear even in the face of malignant tumors, somatic mutations and other factors that are associated with this suffering. And medicine’s path to preventing the deaths that follow such suffering as well as the frailty that denies the aging the opportunity to reach the limit of life in spite of such exceptional mental clarity was elucidated. .

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Section: Aging Individuals Escape Accelerated Deterioration and Suffe...mentioning

confidence: 99%

The Determination of a Verifiable Medical Research Paradigm

Ola¹

2023

Preprint

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“…Sudden cardiac death in the young (SCDY) is defined as "SCD that affects a population aged ≤ 35 years" [4][5][6][7], not athletes and athletes [8,9], with multiple hereditary/genetic or non-hereditary/genetic causes.…”

Section: Introductionmentioning

confidence: 99%

Sudden Cardiac Death in the Young: State-of-the-Art Review in Molecular Autopsy

Salzillo,

Sansone,

Napolitano

2024

CIMB

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Sudden cardiac death (SCD) is defined as unexpected death due to a cardiac cause that occurs rapidly. Despite the identification of prevention strategies, SCD remains a serious public health problem worldwide, accounting for 15–20% of all deaths, and is therefore a challenge for modern medicine, especially when it affects young people. Sudden cardiac death in young people affects the population aged ≤ 35 years, including athletes and non-athletes, and it is due to various hereditary and non-hereditary causes. After an autopsy, if the cause remains unknown, it is called sudden unexplained death, often attributable to genetic causes. In these cases, molecular autopsy—post-mortem genetic testing—is essential to facilitate diagnostic and therapeutic pathways and/or the monitoring of family members of the cases. This review aims to elaborate on cardiac disorders marked by genetic mutations, necessitating the post-mortem genetic investigation of the deceased for an accurate diagnosis in order to facilitate informed genetic counseling and to implement preventive strategies for family members of the cases.

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“…Продолжается научный поиск в вопросах клинической значимости факторов риска, их комбинированного воздействия. Установлена актуальность создания новых неинвазивных методов скрининга, направленных на выявление предикторов и раннюю диагностику БСК [1][2][3][4][5][6][7].…”

Section: Introductionunclassified

A population study of paracardial fat as a risk factor for cardiovascular diseases (based on the data of the Moscow experiment on the use of computer vision in radiodiagnosis)

Vasilev,

Goncharova,

Vladzymyrskii

et al. 2023

Science and Innovations in Medicine

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Aim to study the prevalence of paracardial fat as a risk factor for cardiovascular diseases in Moscow population using an automated analysis of the results of radiological examinations. Material and methods. The research was designed as descriptive, retrospective epidemiological study. The results of chest computed tomography of 113,408 patients served as the study data. The data was analyzed by AI services in an automated mode for the presence of paracardial fat and calculation of its volume. Results. The paracardial fat was detected in 66.5% of the examined persons. The proportion of men was 45.7%, women 54.3% (p0.001). The volume of paracardial fat fluctuated in the range from 1.0 to 1517.0 ml; the average value was 282.1 ml. The average volume of paracardial fat in men (326.0 ml) was significantly larger than in women (244.7 ml) in each age group. The clinically significant volume of paracardial fat (200 ml) was detected in 33,081 individuals (in 64.0% of people having this risk factor). The risk factor was clinically significant in 71.1% of men and in 57.9% of women (p0.001). Conclusion. The prevalence of paracardial fat in Moscow population was 5.97 per 1000 individuals. A clinically significant volume of paracardial fat was most often found in both sexes in the elderly (78.7%) and senile age groups (78.2%). Each 5 years of age increased the probability of this risk factor incidence by 1.282 times in general; and the risk of developing its clinical form by 2.981 times in particular.

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Sudden Cardiac Death in Young Individuals: A Current Review of Evaluation, Screening and Prevention

Cited by 8 publications

References 63 publications

The Determination of a Verifiable Medical Research Paradigm

The Determination of a Verifiable Medical Research Paradigm

Sudden Cardiac Death in the Young: State-of-the-Art Review in Molecular Autopsy

A population study of paracardial fat as a risk factor for cardiovascular diseases (based on the data of the Moscow experiment on the use of computer vision in radiodiagnosis)

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