2021
DOI: 10.1007/s00429-021-02321-9
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Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain

Abstract: Preclinical studies on the effects of abrupt cessation of selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results in alcohol consumption escalation after resuming drinking. However, a potential neuroinflammatory component on this escalation remains unexplored despite the immunomodulatory role of serotonin. Here, we utilized a rat model of 14-daily administration of the SSRI fluoxetine (10 mg/kg/day) along alcohol self-admini… Show more

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Cited by 2 publications
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“…Branched structure analysis, for aging GFAP-IL6 mice compared to age-matched control mice, displayed significant increase in soma area and perimeter, while exhibiting a reduction in circularity, total process length and nodes. The prominent morphological re-orientation of these septal microglia towards a re-activated and de-ramified state, characterized by short and thick branch processes with enlarged soma, represent a neurotoxic phenotype contributing to neurodegeneration [ 74 77 ]. These observations were further confirmed by overall reduction in septal Iba-1 + microglia spatial (convex-hull parameters), and ramification (Sholl parameters) complexity among the aging GFAP-IL6 mice compared to age-matched control mice.…”
Section: Discussionmentioning
confidence: 99%
“…Branched structure analysis, for aging GFAP-IL6 mice compared to age-matched control mice, displayed significant increase in soma area and perimeter, while exhibiting a reduction in circularity, total process length and nodes. The prominent morphological re-orientation of these septal microglia towards a re-activated and de-ramified state, characterized by short and thick branch processes with enlarged soma, represent a neurotoxic phenotype contributing to neurodegeneration [ 74 77 ]. These observations were further confirmed by overall reduction in septal Iba-1 + microglia spatial (convex-hull parameters), and ramification (Sholl parameters) complexity among the aging GFAP-IL6 mice compared to age-matched control mice.…”
Section: Discussionmentioning
confidence: 99%