Sudden death in Parkinson's disease: A retrospective autopsy study

Matsumoto, Hideyuki; Sengoku, Renpei; Saito, Yuko; Kakuta, Yukio; Murayama, Shigeo; Imafuku, Ichiro

doi:10.1016/j.jns.2014.05.060

Cited by 44 publications

(45 citation statements)

References 20 publications

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“…In a large cohort study, 10 out of 131 PD patients (7.6%) were reported to die suddenly [17] . On the other hand, a retrospective autopsy study showed that four out of 16 PD patients had sudden death without any causes [18] . The authors suggested that autonomic dysfunction would cause sudden death in PD.…”

Section: Discussionmentioning

confidence: 99%

PR Prolongation and Cardiac <sup>123</sup>I-MIBG Uptake Reduction in Parkinson's Disease

Mochizuki¹,

Ebihara²,

Ugawa

et al. 2015

Eur Neurol

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Background: Cardiac ¹²³I-metaiodobenzylguanidine scintigraphy (MIBG) previously demonstrated an uptake reduction in patients with Parkinson's disease (PD). However, epidemiologic research showed that electrocardiography (ECG) abnormalities occurred prior to motor signs in PD. Here we investigated whether the electrical conduction system of the heart was impaired in PD. Methods: Clinical features, ECG and MIBG parameters were analyzed in 191 patients with PD, 42 with multiple system atrophy (MSA) and 124 normal controls (NL). Results: The PR interval was significantly longer in patients with PD than in NL. The PR interval was significantly negatively correlated with early and delayed heart-to-mediastinum ratios in MIBG scintigraphy in PD and MSA patients. In 19 PD patients with PR prolongation, 17 patients also had abnormal MIBG findings, and the other 2 showed normal MIBG. Conclusions: The PR prolongation must show some sympathetic system abnormality because it is mainly controlled by the sympathetic nervous system. PR prolongation supports the objective biomarker value of MIBG for PD diagnosis.

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Section: Discussionmentioning

confidence: 99%

PR Prolongation and Cardiac <sup>123</sup>I-MIBG Uptake Reduction in Parkinson's Disease

Mochizuki¹,

Ebihara²,

Ugawa

et al. 2015

Eur Neurol

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“…It has been recognized that PD has a reduced life expectancy due to increased mortality compared to the general population. 3,[11][12][13][14] So far, there is no generally accepted definition for SUDPAR. 7,8 Main causes of death in PD identified by most of the studies are pneumonia and cardiovascular diseases.…”

mentioning

confidence: 99%

“…7,8 Main causes of death in PD identified by most of the studies are pneumonia and cardiovascular diseases. 3,14 However, neuroscientists are trying to define key risk factors, causal mechanisms (possibly cardiovascular), and effective preventive measures. 11 Surprisingly, what is still under debate is the occurrence of "Sudden Unexpected Death in Parkinson's Disease" (SUDPAR).…”

mentioning

confidence: 99%

“…9,10 These results are comprehensible as it is very well established that cardiac abnormalities found in PD patients are manifold, but the most prominent is cardiac autonomic dysfunction. 3,14 While the possible mysteries of SUDPAR are not uncovered, a cooperative strategy between neurologists and cardiologists must be established with regard to SUDPAR. 3,[11][12][13][14] So far, there is no generally accepted definition for SUDPAR.…”

mentioning

confidence: 99%

“…11 Surprisingly, what is still under debate is the occurrence of "Sudden Unexpected Death in Parkinson's Disease" (SUDPAR). 3,[11][12][13][14] So far, there is no generally accepted definition for SUDPAR. Concerning a didactic definition, SUDPAR was conceptualized as an unexpected death in a patient with PD without any satisfactory explanation of death as determined by autopsy studies.…”

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confidence: 99%

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In brief: Sudden unexpected death in Parkinson's disease

et al. 2018

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Increased atrial fibrillation risk in Parkinson’s disease: A nationwide population‐based study

Han

Moon

Choi

et al. 2021

Ann Clin Transl Neurol

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ObjectiveParkinson’s disease (PD) is the second most common neurodegenerative disorder associated with various morbidities. Although the relationship between cardiovascular disease and PD has been studied, a paucity of information on PD and atrial fibrillation (AF) association exists. Thus, we aimed to investigate whether patients with PD have an increased risk of AF.MethodsThis study included 57,585 patients with newly diagnosed PD (≥40‐year‐old, mean age 69.7 years, men 40.2%) and without a history of AF from the Korean National Health Insurance Service (NHIS) database between 2010 and 2015. Furthermore, an equal number of age‐ and sex‐matched subjects without PD were selected for comparison. The primary outcome was new‐onset AF.ResultsDuring the mean follow‐up period of 3.4 ± 1.8 years, AF was newly diagnosed in 3,665 patients. A significantly higher incidence rate of AF was noted among patients with PD than among patients without PD (10.75 and 7.86 per 1000 person‐year, respectively). Multivariate Cox‐regression analysis revealed that PD was an independent risk factor for AF (hazard ratio [HR]: 1.27, 95% confidence interval [CI]: 1.18–1.36). Furthermore, subgroup analyses revealed that AF risk was higher in the younger age subgroups, and compared with the non‐PD group, the youngest PD group (age: 40–49 years) had a threefold increased risk of AF (HR: 3.06, 95% CI: 1.20–7.77).InterpretationPatients with PD, especially the younger age subgroups, have an increased risk of AF. Active surveillance and management of AF should be considered to prevent further complications.

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Sudden death in Parkinson's disease: A retrospective autopsy study

Cited by 44 publications

References 20 publications

PR Prolongation and Cardiac <sup>123</sup>I-MIBG Uptake Reduction in Parkinson's Disease

PR Prolongation and Cardiac <sup>123</sup>I-MIBG Uptake Reduction in Parkinson's Disease

In brief: Sudden unexpected death in Parkinson's disease

Increased atrial fibrillation risk in Parkinson’s disease: A nationwide population‐based study

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