Sudden onset of vitiligo after COVID‐19 vaccine

Abstract

Dear Editor, Cutaneous and extracutaneous autoimmune diseases (ADs) have rarely been reported in association with COVID-19 vaccine. 1,2 We described herein a case of sudden onset of vitiligo occurring after the first dose of COVID-19 vaccine. To date, only two cases of vitiligo in COVID-19-vaccinated patients have been described. 3 A 33-year-old female presented us with a 45-days history of milky-white well-demarcated, oval and liner-shaped macules on her trunk, neck and back (Figure 1A,B) which had appeared 1 week after receiving her first dose of Pfizer-BioNTech COVID-19 vaccine. The second dose of vaccine was injected 1 months later without the appearance of new macules.

Newly‐developed vitiligo following COVID‐19 mRNA vaccine

“… 4 Third case of vitiligo with COVID‐19 mRNA vaccine was also with Pfizer‐Biontech vaccine in a 33‐year‐old female patient who had unremarkable medical history. 5 All patients reported no personal nor family history of vitiligo. It is not clear that vitiligo was caused by vaccination, but the temporal relationship between the disease development and vaccination is interesting in all cases.…”

New‐onset vitiligo following COVID‐19 disease

“…3,4 New onset of vitiligo and hypopigmentations have been described following COVID-19 vaccination. [5][6][7][8] However, vitiligo has never been described after COVID-19 infection up to date.…”

Vitiligo following COVID-19: A case report and review of pathophysiology

“…Of interest, there have been multiple cases reporting new-onset of vitiligo within several days to 1 week after patients received first doses of COVID-19 messenger RNA vaccinations. 9,10 We postulate that this patient's atypical history and sequential relationship of SARS-CoV-2 infection to onset of vitiligo, in conjunction with the existence of robust pathophysiologic theories to explain the phenomenon, support the diagnosis of COVID-induced vitiligo.…”