Sudden, unexpected death due to undiagnosed frontal glioblastoma in a schizophrenic patient

Shiferaw, Kebede; Pizzolato, Gianpaolo; Perret, George; Harpe, R. La

doi:10.1016/j.forsciint.2005.08.006

Cited by 11 publications

(6 citation statements)

References 12 publications

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“…In 7 cases there were no neurological symptoms before the death and the patients were found suddenly death [1,20,25]. In one case there was headache 2 hours before death [30], in 1 case the man was disoriented, slow, somnolent, five days before the death [28] and in a case of the child of 10 weeks there was irritability for one day and large vomit before the death (Table 1) [29]. …”

Section: Discussionmentioning

confidence: 99%

Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature

et al. 2013

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Sudden death from an undiagnosed primary intracranial neoplasm is an exceptionally rare event, with reported frequencies in the range of 0.02% to 2.1% in medico-legal autopsy series and only 12% of all cases of sudden, unexpected death due to primary intracranial tumors are due to glioblastomas. We present three cases of sudden, unexpected death due to glioblastoma, with different brain localization and expression. A complete methodological forensic approach by means of autopsy, histological and immunohistochemical examinations let us to conclude for an acute central dysregulation caused by glioblastoma and relative complication with rapid increase of intracranial pressure as cause of death. Although modern diagnostic imaging techniques have revolutionized the diagnosis of brain tumors, the autopsy and the careful gross examination and section of the fixed brain (with coronal section) is still the final word in determining exact location, topography, mass effects and histology and secondary damage of brain tumor and contributed the elucidation of the cause of death. Immunohistochemistry and proteomic analysis are mandatory in such cases.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1218574899466985

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Section: Discussionmentioning

confidence: 99%

Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature

et al. 2013

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“…The cause of death may be due entirely to the effect of the brain tumor. [5][6][7] Alternatively, the brain tumor may have led to complications that caused or facilitated death, as appears to have been the case in this decedent. 6 Rarely, the patient may have been found in acute distress antemortem and died after brief intervention, leading to the diagnosis of intracranial malignancy at autopsy.…”

Section: Discussionmentioning

confidence: 99%

Death from undiagnosed glioblastoma multiforme and toxic self-medication presenting with concurrent dysfunctional behavior

Carson¹,

Eilers

2008

Journal of Forensic and Legal Medicine

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“…Some of them were relevant to pituitary apoplexy, 13 brainstem glioma, 14 frontal glioblastoma in schizophrenic patient, 15 low-grade medullary pontine fibrillary astrocytoma of brainstem, 16 intracranial inflammatory pdeudotumor in a patient with homocystinuria, 17 intracranial hemangiopericytoma, 12 primary intracranial germinoma, 18 malignant melanoma of the temporal lobe associated with neurocutaneous melanosis, 19 and a ruptured intracranial dermoid cyst. Some of them were relevant to pituitary apoplexy, 13 brainstem glioma, 14 frontal glioblastoma in schizophrenic patient, 15 low-grade medullary pontine fibrillary astrocytoma of brainstem, 16 intracranial inflammatory pdeudotumor in a patient with homocystinuria, 17 intracranial hemangiopericytoma, 12 primary intracranial germinoma, 18 malignant melanoma of the temporal lobe associated with neurocutaneous melanosis, 19 and a ruptured intracranial dermoid cyst.…”

Section: Discussionmentioning

confidence: 99%

Sudden Unexpected Death From Oligodendroglioma

Manousaki

Papadaki

Papavdi

et al. 2011

American Journal of Forensic Medicine &Amp; Pathology

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Sudden and unexpected deaths due to asymptomatic 5 primary brain tumors are extremely rare, with an incidence that ranges from 0.16 to 3.2%. Usually, such tumors are glioblastomas or, less commonly, astrocytomas. Asymptomatic oligodendrogliomas causing sudden death are hardly ever reported among medico-legal investigated cases.We report a rare case of sudden and unexpected death from a previously asymptomatic and undiagnosed, well-differentiated, grade II oligodendrogloioma (WHO classification). According to the autopsy and the microscopic findings brain edema as a result of obstruction of the cerebrospinal fluid flow due to hemorrhagic leakage of the oligodendroglioma is incriminated as the most probable physiopathological mechanism for the sudden death. Diagnosis is mainly based on the special microscopic features of the tumor cells (typical "fried-egg" appearance), interrupted by a dense network of branching capillaries. We discuss further the pathophysiological mechanisms of death and present a short review of literature.

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Sudden, unexpected death due to undiagnosed frontal glioblastoma in a schizophrenic patient

Cited by 11 publications

References 12 publications

Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature

Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature

Death from undiagnosed glioblastoma multiforme and toxic self-medication presenting with concurrent dysfunctional behavior

Sudden Unexpected Death From Oligodendroglioma

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