Sudor Anglicus: an epidemic targeting the autonomic nervous system

Cheshire, William P.; Gerpen, Jay A. van; Sejvar, James J.

doi:10.1007/s10286-020-00698-x

Cited by 5 publications

(11 citation statements)

References 41 publications

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“…Such a skew in demographics may be important to keep in mind when investigating burial sites. Interestingly, the English sweating disease was reported to have killed preferentially middle aged men, with few deaths observed in children, women and the elderly [166,169].…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms included high fever, headache, hyperhidrosis, palpitations, stomach ache, dyspnea, madness, and many more. The estimated mortality rate was 30-50% [165,166]. John Caius of Cambridge, then president of the Royal College of Physicians, published in 1552 an account of the sweating disease, the first monograph entirely devoted to an infectious disease (see [167]).…”

Section: Historical Publications As a Source Of Past Epidemicsmentioning

confidence: 99%

“…John Caius of Cambridge, then president of the Royal College of Physicians, published in 1552 an account of the sweating disease, the first monograph entirely devoted to an infectious disease (see [167]). Over the years, the causative agent of sweating disease has been proposed, and mostly dismissed, to be Bacillus anthracis (the cause of anthrax), Vibrio cholerae, influenza virus, or a hantavirus, amongst others [165,166,[168][169][170][171]. Cheshire et al have argued that the etiological agent of sweating disease would likely be a virus affecting the autonomic nervous system [166].…”

Section: Historical Publications As a Source Of Past Epidemicsmentioning

confidence: 99%

“…Over the years, the causative agent of sweating disease has been proposed, and mostly dismissed, to be Bacillus anthracis (the cause of anthrax), Vibrio cholerae, influenza virus, or a hantavirus, amongst others [165,166,[168][169][170][171]. Cheshire et al have argued that the etiological agent of sweating disease would likely be a virus affecting the autonomic nervous system [166]. Interestingly, autonomic dysfunction, sometimes with hyperhidrosis, is a prominent feature of acute SARS-CoV-2 infection [172,173].…”

Section: Historical Publications As a Source Of Past Epidemicsmentioning

confidence: 99%

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Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens

Kuyl¹

2022

Preprint

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Since life on earth developed, parasitic microbes have thrived. Increases in host numbers, or the conquest of a new species, provides an opportunity for such a pathogen to enjoy, before host defense systems kick in, a similar upsurge in reproduction. Outbreaks ‒ caused by ‘endemic’ pathogens ‒ and epidemics ‒ caused by ‘novel’ pathogens ‒ have thus been creating chaos and destruction since prehistorical times. To study such (pre)historic epidemics, recent advances in the ancient DNA field, applied to both archeological and historical remains, have helped tremendously to elucidate the evolutionary trajectory of pathogens. These studies offered new and unexpected insights in the evolution of, for instance, smallpox virus, hepatitis B virus and the plague-causing bacterium Yersinia pestis. Furthermore, burial patterns and historical publications can help in tracking down ancient pathogens. Another source of information is our genome, where selective sweeps in immune-related genes relate to past pathogen attacks, while multiple viruses have left their genomes behind for us to study.

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Section: Discussionmentioning

confidence: 99%

Section: Historical Publications As a Source Of Past Epidemicsmentioning

confidence: 99%

Section: Historical Publications As a Source Of Past Epidemicsmentioning

confidence: 99%

Section: Historical Publications As a Source Of Past Epidemicsmentioning

confidence: 99%

See 2 more Smart Citations

Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens

Kuyl¹

2022

Preprint

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“…A recent review described the autonomic nervous system as the main target with possible pathological involvement at the hypothalamus, serotonergic neurons, autonomic ganglia, peripheral sympathetic nerves, neuroeffector junctions, or eccrine glands. 12 It was reported that the annals of Merton College, University of Oxford, contain records of treatment. Though written in Latin, a sentence from the record reads, "this .…”

Section: Clinical Featuresmentioning

confidence: 99%

The English sweating sickness of 1485-1551 and the ecclesiastical response

Fagunwa

Fagunwa²

2020

han-j-cjgh

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During the 15th and 16th centuries, five epidemics of a disease characterized by high fever and profuse sweating ravaged England. The disease became known as English sweating sickness because it started in England, though it also struck Ireland and mainland Europe. The infectious disease was reportedly marked with pulmonary components, and the mortality rate was estimated to be between 30% and 50%. The evidence of the “sweating sickness” story is medically fascinating and historically noteworthy as to its sudden appearance in 1485 and major disappearance in 1551. This was a period when the Church of England broke away from the Roman Catholic Church; and the then Prince of Wales, Arthur Tudor, died possibly of sweating sickness. The Church played a vital role during those periods: responses were made in the form of treatment (in Germany), ecclesiastical prayers, tailored worship, and devotions during those trying times, and the preservation of fragile records relating to the epidemics.

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The sweat rate as a digital biomarker in clinical medicine beyond sports science

Brasier,

Niederberger,

Salvatore

2024

Soft Sci

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Sweating is an important physiological reaction and a clinical symptom in a variety of diseases. However, sweating remains underrated in clinical use. Gold standards to measure the sweat rate are neither continuous, nor easily or lab-independently applicable. With the emergence of novel wearable devices, using sweat rate as a novel digital biomarker shows promise for clinical monitoring and diagnostics. In this Commentary, we discuss the potential and importance of the sweat rate as a digital biomarker beyond sport science.

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Sudor Anglicus: an epidemic targeting the autonomic nervous system

Cited by 5 publications

References 41 publications

Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens

Historic and Prehistoric Epidemics: An Overview of Sources Available for the Study of Ancient Pathogens

The English sweating sickness of 1485-1551 and the ecclesiastical response

The sweat rate as a digital biomarker in clinical medicine beyond sports science

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