Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit/Hyperactivity Disorder

Yu, Ching Jung; Du, Jung Chieh; Chiou, Hsien Chih; Feng, Chun Cheng; Chung, Ming Yi; Yang, Winnie; Chen, Ying Sheue; Chien, Ling-Chu; Hwang, Betau; Chen, Mei Lien

doi:10.3390/ijerph13070678

Cited by 62 publications

(43 citation statements)

References 92 publications

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“…Other studies such as that of da Silva et al (23) and Muller et al (24) found no association. There was also no significant relationship between ADHD and the incidence of dopamine transporter allele in the study of Yu et al but a significant relationship was observed between this disease and the allele of dopamine receptor (25).…”

Section: Discussionmentioning

confidence: 55%

DAT1 Gene Polymorphism in Children with Attention Deficit Hyperactivity Disorder

et al. 2018

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Background: Attention deficit hyperactivity disorder (ADHD) as a commonneuro -developmental disorder is associated with inattention, excessive activity, impulsive behavior or a combination of these symptoms. Environmental and genetic factors are involved in this disorder; Dopamine Active Transporter 1 gene (DAT1) is one of these genetic factors. In this study the association between the 10 or 9 -repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region (UTR) of the DAT1 gene and ADHD, is examined. Methods: A total of 124 children with ADHD and 129 healthy children, ranging from 5 to 14 years old were selected from the north -western area of Iran as the case group and the control group, respectively. DAT1 gene polymorphism was investigated using the PCR-VNTR technique. Results: Using the Hardy -Weinberg law and chi -square test for analyzing the results of the DAT1 gene, it was observed that the genotypes 9/10 and 10/10 of DAT1 gene were significantly higher among children with ADHD than that in control group (P = 0.002). Conclusions: Based on these finding, it can be concluded that a significant relationship exists between DAT1 gene repeats and ADHD in North -west Iran and this can be used as a diagnostic biomarker in the prognosis of this disorder.

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Section: Discussionmentioning

confidence: 55%

DAT1 Gene Polymorphism in Children with Attention Deficit Hyperactivity Disorder

et al. 2018

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“…Some authors on the other hand have reported a greater correlation and believe there is a connection between ADHD and sugary drink consumption. [ 25 ]…”

Section: Effects On Healthmentioning

confidence: 99%

Lactose, Maltose, and Sucrose in Health and Disease

Qi¹,

Tester²

2020

Molecular Nutrition Food Res

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Scope: This review represents a focus on the structure and properties of the common nutritional disaccharides (lactose, maltose, and sucrose) in health and disease. The aim is to provide a comprehensive reference source related to the role of disaccharides in human nutrition. Methods and results: Key reference sources are searched, including Web of Science, PubMed, Science Direct, and Wiley Online, and key reference works are selected to support the factual basis of the text where interpretations and relevance of the works are discussed in the review. There are key nutritional health benefits of receiving dietary energy in the form of sugars, but equally life-threatening issues exist associated with constant/excess consumption. These issues are discussed together with genetic disorders, which impact upon health associated with consumption of the disaccharides (e.g., specific disaccharide intolerance due to deficiency of relevant digestive enzymes). Conclusions: As the three common dietary disaccharides (lactose, maltose, and sucrose) are consumed on a very regular basis in the human diet, it is critical to understand insofar as possible their role in health and disease. This review provides an insight into the structure and properties of these molecules in health and disease.

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“…With the mass introduction of linoleic-acid-rich vegetable oils, such as that in Astrofood, the omega-6 to omega-3 ratio in the westernized diet is now around 16:1, and in some transitioning nations is as high as 50:1 [74]. Dominance of omega-6 relative to omega-3 has been linked to obesity, depression and childhood learning and behavioral disorders [75][76][77][78]; Second, added sugars, also foreign to ancestral experiences, have been linked with depression and behavioral disorders in human and animal research; mechanisms by which sugar could provoke mood, cognitive or behavioral disturbances include diminished levels of brain derived neurotrophic factor (BDNF) that otherwise supports stability and growth of nerves even past middle-age, elevation of inflammatory immune proteins such as cytokines (the elevation of which can compromise mood, disturb cognitive focus and increase anxiety), changes in blood-glucose-insulin control (which can effect subsequent mood), and addiction-like effects of sugar and sugar-fat combinations working through dopamine-mediated reward centers in the brain [79][80][81]. The effects of highly-palatable sugar or sugar-fat combinations may be especially disruptive to brain and behavior when encountered early in life [82].…”

Section: Deconstructing Astrofoodmentioning

confidence: 99%

Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift

Logan

Prescott

2017

Challenges

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Abstract:Recognizing the importance of nutrition as part of the grand challenges faced by humanity-the current epidemic of non-communicable diseases (NCDs), sustainability and maintenance of Planetary Health-the United Nations (UN) has declared 2016-2025 the Decade of Nutrition. Research continues to underscore the extent to which ultra-processed foods dominate the contemporary nutritional landscape. Moreover, the dual role played by food technology and marketing in the expansion of ultra-processed foods is under increased scrutiny. As public health experts and clinicians contend with a crisis of NCDs, attempting to untangle a knotted assortment of interrelated strands of causation, an examination of the early origins of highly-marketed ultra-processed foods can provide valuable lessons. Here, we illuminate a little-known piece of history in the annals of ultra-processed nutritional science and childhood welfare. Astrofood was a commercially-marketed, collaborative government-industry effort that brought soy protein-enriched Twinkies as a nutritive breakfast cake to disadvantaged children; its concept and delivery demonstrated an unwillingness to deal with root-cause challenges. Although its official tenure was only about 7 years, we argue that Astrofood and its total food engineering still resonate throughout the global ultra-processed nutritional landscape. New scientific advances in nutritional psychiatry and the microbiome are on a collision course with the profits, marketing and intellectual dishonesty of the ultra-processed food industry. Solutions to the grand challenges of the Decade of Nutrition may be found in lessons from Astrofood. They provide clues to undoing the tangled knots which otherwise maintain an untenable status quo.

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Sugar-Sweetened Beverage Consumption Is Adversely Associated with Childhood Attention Deficit/Hyperactivity Disorder

Cited by 62 publications

References 92 publications

DAT1 Gene Polymorphism in Children with Attention Deficit Hyperactivity Disorder

DAT1 Gene Polymorphism in Children with Attention Deficit Hyperactivity Disorder

Lactose, Maltose, and Sucrose in Health and Disease

Astrofood, Priorities and Pandemics: Reflections of an Ultra-Processed Breakfast Program and Contemporary Dysbiotic Drift

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