Background: The relationship between sugar-sweetened beverages (SSBs) intake and serum lipids among children and youth has been reported in several studies, but the results are still controversial.Objective: In the current study, we summarized the results of studies that assessed the relationship between SSBs consumption and serum lipids among children and youth in a systematic review and dose-response meta-analysis.Methods: The PubMed, Web of Sciences, Cochrane and Scopus electronic databases were searched for observational studies reporting an association between SSBs intake and serum lipids among children and youth that were published before May 2020. For data extracted from cohort studies, only cross-sectional baseline data were included in the current meta-analysis. The Random effects model was used to estimate the pooled weighted mean difference (WMD) and 95% confidence intervals (CI). Heterogeneity was assessed with the Cochran Q test and I 2 statistics.Results: In our search, 1845 studies were retrieved of which 13 studies (two cohorts and eleven cross-sectional) were included. High SSB consumption was associated with 1.21 mg/dL increase in low-density lipoprotein cholesterol (LDL-C; pooled WMD: 1.21 mg/dL; 95% CI: 0.23, 2.20; P = .01), 1.45 mg/dL decrease in high-density lipoprotein cholesterol (HDL-C, pooled WMD: −1.46 mg/dL; 95% CI, −2.25, −0.67; P < .0001) and 2.49 mg/dL decrease in total cholesterol (TC, pooled WMD: −2.49 mg/dL; 95% CI, −2.89, −2.10; P < .0001). In dose-response meta-analysis, there was an evidence of departure from linearity in the relationship between SSB consumption and change in LDL-C (Pnonlinearity = .03) and TC (Pnonlinearity = .01). However, no departure from linearity was observed between SSB intake and change in HDL-C (Pnonlinearity = .56) or triglyceride (TG) values (Pnonlinearity = .85).
Conclusion:According to our results, high SSB consumption was significantly associated with higher LDL-C and lower HDL-C and TC among children and youth.