Objective: Muslims living in the United States (MLUS) report high mental health stigma. They also underutilize professional psychological help, despite experiencing rising Islamophobia and comparatively poorer mental health. In line with double stigma, we examined whether MLUS who perceived greater Islamophobia also experienced greater self-stigma of seeking help, and whether this was related to negative help-seeking attitudes. We also assessed therapist demographic and treatment modality preferences and explored how they related to risk factors for low help-seeking. Method: Utilizing a representative sample of 350 MLUS (50% women, 33% immigrants) acquired via a Qualtrics panel aggregate, we assessed a path model of help-seeking attitudes to determine the direct and indirect effects of perceived Islamophobia via self-stigma and psychological distress. Therapist and treatment preferences were examined via multiple regression models and analysis of variance (ANOVAs). Open-ended responses were coded through content analysis. Results: Perceived Islamophobia was associated with greater psychological distress and also indirectly related to negative help-seeking attitudes via greater self-stigma. Therapists of a similar background, therapy in a mosque-setting, group therapy, and imam collaboration were more appealing to MLUS who were at risk for low help-seeking. Conclusions: Among MLUS, perceived Islamophobia may present a dual risk-simultaneously increasing psychological distress and indirectly leading to negative attitudes toward help-seeking via higher self-stigma. Conversely, for MLUS at risk for low help-seeking, accessible community-based treatments and treatment with a Muslim or race/ethnicity-matched therapist may facilitate help-seeking behaviors. Future work may determine whether addressing double stigma within Muslim communities (e.g., Islamophobia and self-stigma) may improve psychological help-seeking.