Suicides are seldom prescribed antidepressants: findings from a prospective prescription database in Jämtland county, Sweden, 1985–95

Henriksson, S.; Boëthius, Göran; Isacsson, Göran

doi:10.1034/j.1600-0447.2001.00276.x

Cited by 66 publications

(59 citation statements)

References 23 publications

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“…Suicidal behavior correlates with inadequate prescription of antidepressants, 32 and from 1978 to 1997, the proportion of the outpatient US population with depression receiving at least 1 antidepressant prescription increased from 37.3% to 74.5%. 8,10,43 Mood disorders accounted for 45% of all antidepressant prescriptions in 1997 and 59% in 2000, 31 so both the proportion and therefore the impact of more prescriptions on mood disorders are likely to have been sustained over this limited period for which we have data.…”

Section: Commentmentioning

confidence: 99%

The Relationship Between Antidepressant Medication Use and Rate of Suicide

Gibbons¹,

Hur²,

Bhaumik³

et al. 2005

Arch Gen Psychiatry

362

196

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The aggregate nature of these observational data preclude a direct causal interpretation of the results. A high number of TCA prescriptions may be a marker for those counties with more limited access to quality mental health care and inadequate treatment and detection of depression, which in turn lead to increased suicide rates. By contrast, increases in prescriptions for SSRIs and other new-generation non-SSRIs are associated with lower suicide rates both between and within counties over time and may reflect antidepressant efficacy, compliance, a better quality of mental health care, and low toxicity in the event of a suicide attempt by overdose.

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Section: Commentmentioning

confidence: 99%

The Relationship Between Antidepressant Medication Use and Rate of Suicide

Gibbons¹,

Hur²,

Bhaumik³

et al. 2005

Arch Gen Psychiatry

362

196

View full text Add to dashboard Cite

show abstract

“…Furthermore, the perception of functional impairment, is often more critical in suicidality than the objective disability produced by disease (11,12), again testifying to the importance of depressive cognitions. ThatÕs why it is tragic that most individuals who commit suicide in the community had rarely received the benefit of adequate pharmacologic, psychotherapeutic or electroconvulsive treatment for depression (13)(14)(15)(16).…”

Section: ôDepressionõ As the Final Common Pathway In Suicidementioning

confidence: 99%

Targeting suicide prevention to modifiable risk factors: has bipolar II been overlooked?

Akiskal

2007

Acta Psychiatr Scand

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“…Swedish studies in 1970-1984 and 1985-1995 found that only 15% and 12% of individuals who committed suicide in the Swedish county of Jämtland during those periods had filled prescriptions of antidepressants during their last three months before suicide (Henriksson, Boethius & Isacsson, 2001;Isacsson, Boëthius & Bergman, 1992). The San Diego study (1981)(1982)(1983) found that only 23% of suicides diagnosed post-mortem with major, bipolar, or atypical depression had been prescribed antidepressants within 90 days of death (Isacsson, Bergman & Rich, 1994a).…”

Section: Under-treatment With Antidepressantsmentioning

confidence: 99%

Antidepressant drug use and suicide prevention

Isacsson¹,

Rich²

2005

International Review of Psychiatry

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Depression has been identified as occurring in the majority of people who commit suicide. Effective antidepressant medications have been available for over half a century. It seems logical to conclude that treatment of depression with antidepressants would have a suicide preventive effect. This has been difficult to demonstrate due to the infrequency of suicide and methodological problems in prospectively testing the hypothesis. Pooled data from controlled clinical trials of antidepressants have not demonstrated a suicide preventive effect, but patient selection and the brief time of most trials limits the power of the data. Some reports from either long-term or very large databases have provided evidence that antidepressants prevent suicide. All but one study using aggregated data from naturalistic settings have shown inverse relationships between use of antidepressants and suicide rates in various populations. Definite conclusions cannot be drawn from naturalistic studies since unknown confounders cannot be excluded. The number of geographically widespread studies reporting positive results with varying methods leads us to conclude, however, that antidepressants do exert a suicide preventive effect.

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Suicides are seldom prescribed antidepressants: findings from a prospective prescription database in Jämtland county, Sweden, 1985–95

Abstract: There is a frequent use of psychotropics and psychiatric care among suicides; however, few used antidepressants and complied. Many suicides are still misdiagnosed and are not adequately treated.

Cited by 66 publications

References 23 publications

The Relationship Between Antidepressant Medication Use and Rate of Suicide

The Relationship Between Antidepressant Medication Use and Rate of Suicide

Targeting suicide prevention to modifiable risk factors: has bipolar II been overlooked?

Antidepressant drug use and suicide prevention

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