Sulcal Plaque pH and Remineralization of Sulcal Caries in Rats Exposed to Dietary and Water Fluoride

Firestone, Allen R.; Navia, Juan M.

doi:10.1159/000261102

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…More re cently, LDH has been implicated in reducing the severity of dental caries in rats [Bibby et al, 1985], The availability of suitable cariogenic diets [Navia et al, 1969] and the development of caries scoring tech niques [König et al, 1958;Green and Hartles, 1967] has enabled laboratory rats to be used extensively as reliable models for studying the effects of various fac tors on dental caries [Navia, 1977;Bowen et al, 1980;Firestone and Navia, 1988;Shern, 1988]. The purpose of this study was to determine whether the addition of LDH to high and low sucrose in the diet and drinking water may be important in reducing the number and severity of caries lesions in laboratory rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of Lactate Dehydrogenase on Fissure Caries in Rats

Higham

Edgar²

1990

Caries Res

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The effect of supplementing the diet or drinking water with lactate dehydrogenase (LDH) on the formation of caries lesions in rats was investigated. Addition of LDH [20 and 5 mg/kg in the high-sucrose (65%) diet, 2 and 1 U/ml in the drinking water (LDH-specific activity 735 U/mg solid)] resulted in significant reductions (p < 0.01) in the number and severity of caries lesions when the enzyme was administered to rats for 4 or 7 days, although no significant differences were found after 14 or 21 days. No differences were observed between effects of addition to water or diet. Fissure caries failed to develop when rats were fed a low sucrose diet (5%) containing LDH (20 mg/kg diet), whereas 50% of the animals in the control group developed lesions. The findings indicate that LDH may play an important role in delaying the onset of caries lesion formation in rats, and that the protection observed may be inversely related to the intensity of the cariogenic challenge.

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Section: Introductionmentioning

confidence: 99%

Effects of Lactate Dehydrogenase on Fissure Caries in Rats

Higham

Edgar²

1990

Caries Res

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The Effects of Different Levels of Dietary Sucrose on Root Caries subsequent to Gingivectomy in Conventional Rats Infected with Actinomyces viscosus M-100

1988

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Three groups of weanling, Sprague-Dawley-derived rats were inoculated with Actinomyces viscosus M-100 and fed powdered diet containing either 67%, 5%, or 0% confectioner's sugar. Two further groups were fed diet containing 5% confectioner's sugar and inoculated with Streptococcus sobrinus 6715 or S. sobrinus 6715 plus A. viscosus M-100. The most coronal 1 mm ofgingiva was removed from maxillary and mandibular right molar quadrants (gingivectomy), and the animals re-inoculated following gingivectomy. The animals were killed 64 days following gingivectomy, and the lingual surface ofmandibular first molar roots was measured for exposed root-surface area and root caries. In the groups of rats infected with A. viscosus M-100, root caries area was significantly greater in the group fed diet containing 67% confectioner's sugar. Sucrose level did not significantly affect the amount of exposed lingual first molar root area regardless of whether the tooth had been subjected to a gingivectomy. In the groups of rats receiving diet containing 5% confectioner's sugar, there were no significant differences in root caries area or exposed root-surface area, regardless of the infection status of the animals. In the rat model presented here, a high level of dietary sucrose was a necessary condition for the initiation of root caries in the absence of other readily fermentable carbohydrates.

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Study on the caries incidence of tetracycline administered rats.

Ueno

1990

J Dent Hlth

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This study was designed to examine the caries incidence of tetracycline administered rats. The experiment was divided into three series. In the first series, the rats were daily injected subcutaneously with tetracycline hydrochloride (50mg/kg body weight) from 10 days of age to weaning at 21 days of age. Rats injected with saline solution served as controls, and caries incidence was compared. In the second series, the caries inhibitory effects of fluorides (NaF in drinking water or topical application of APF) on tetracycline administered rats were assessed. In the third series, the acid resistance and the Vickers microhardness of enamel were measured in lower first molars. The results obtained were as follows: 1) Compared with the control group, dental caries was significantly increased in tetracycline administered rats. 2) Dental caries in tetracycline administered rats was drastically reduced when fluorides were applied. 3) The acid resistance in tetracycline-affected enamel was decreased, but it was increased when fluorides were applied. Microhardness of tetracycline-affected enamel was decreased, but a rehardening was shown when APF was topically applied. On the basis of these results, I conclude that the caries resistance is decreased in tetracycline administered rats by reduction in acid resistance and hardness of tetracycline-induced hypoplastic enamel, but it is increased when fluorides are applied.

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Sulcal Plaque pH and Remineralization of Sulcal Caries in Rats Exposed to Dietary and Water Fluoride

Cited by 3 publications

References 14 publications

Effects of Lactate Dehydrogenase on Fissure Caries in Rats

Effects of Lactate Dehydrogenase on Fissure Caries in Rats

The Effects of Different Levels of Dietary Sucrose on Root Caries subsequent to Gingivectomy in Conventional Rats Infected with Actinomyces viscosus M-100

Study on the caries incidence of tetracycline administered rats.

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