Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies

Kumar, Nitin; Thatikonda, Sowjanya; Tokala, Ramya; Kumari, Shikha; Lakshmi, Uppu Jaya; Godugu, Chandraiah; Shankaraiah, Nagula; Kamal, Ähmed

doi:10.1016/j.bmc.2018.02.050

Cited by 39 publications

(23 citation statements)

References 51 publications

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“…Some recent reports suggested that the antiproliferative activity of quinolinones resulted from the interaction with inhibition of tubulin polymerization. [35][36][37] Thus, we also evaluated the abilities of levooxacin-HDACi conjugates 6-9 in inhibiting the tubulin polymerization ( Table 2).…”

Section: Tubulin Polymerization Inhibitionmentioning

confidence: 99%

Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents

et al. 2018

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Section: Tubulin Polymerization Inhibitionmentioning

confidence: 99%

Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents

et al. 2018

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“…Dual AO/EB fluorescent staining was employed to distinguish living cells and apoptotic cells. AO can penetrate intact cells and stain the nucleus green, whereas EB can only penetrate the cells with damaged membrane and stain the nucleus red (Kumar et al, ). As can be seen from the Figure b1, the control group cells showed bright green fluorescence and complete cell structure.…”

Section: Resultsmentioning

confidence: 99%

Section: Cytological Effect Of Ellagic Acid On B 16 Mouse Melanoma mentioning

confidence: 99%

Antityrosinase mechanism of ellagic acid in vitro and its effect on mouse melanoma cells

Huang

Chai

et al. 2019

J Food Biochem

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The activities of ellagic acid in inhibiting mushroom tyrosinase and cell proliferation were evaluated in this research. The results of enzyme kinetics indicated that ellagic acid could effectively inhibit tyrosinase activity. The value of the semi‐inhibitory rate (IC50) was 0.2 ± 0.05 mM. Ellagic acid inhibited tyrosinase activity in a reversible manner and was a mixed tyrosinase inhibitor. Furthermore, ellagic acid had a good inhibitory effect on the proliferation of mouse melanoma B16 cells and could induce apoptosis. The results acquired from fluorescence spectroscopy revealed that the interaction of ellagic acid with tyrosinase depended on hydrogen bond and electrostatic force. In addition, computational docking showed that ellagic acid interacted with amino acid residues of tyrosinase (Asn19 and Lys372) by hydrogen bond and produced electrostatic interaction with amino residue Lys18. Practical applications In the present research, the antityrosinase mechanism of ellagic acid and its effect on mouse melanoma cells were investigated. This study suggested that ellagic acid had a strong inhibitory activity against tyrosinase and cell proliferation,which laid an experimental foundation for the development of new drugs and whitening products. The combined multispectral methods used in this research can be applied to the screening of other antityrosinase inhibitors, further promoting the development and utilization of tyrosinase inhibitors.

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“…In order to reveal whether arrest of cell cycle was mechanistically responsible for sensitizing lung cancer cells towards apoptosis, the flow cytometric analysis was performed to analyse the distribution of the cell population in various cell cycle phases (Mani et al, 2017). Here, A549 cancer cells were incubated with compound 4q at various concentrations ranging from 0.5 to 5 µM for 48 h. Untreated and treated cells were harvested, washed and fixed overnight in 70% ethanol in PBS at -20 o C. Fixed cells were pelleted and stained with cell cycle analysis reagent propidium iodide (50 μg/ml) with RNase A for 20 min at 37 o C in dark and about 10,000 events were acquired and analyzed on a flow cytometer (Kumar et al, 2018a).…”

Section: Cell Cycle Analysismentioning

confidence: 99%

Design, One Pot Synthesis and Molecular Docking Studies of Substituted-1H-Pyrido[2,1-b] Quinazolines as Apoptosis-Inducing Anticancer Agents

Bathula

Satla

Kyatham

et al. 2020

Asian Pac J Cancer Prev

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Cancer is one of the leading causes of death worldwide and accounts for almost 13% deaths than any other infectious diseases (Thun et al., 2010). According to World Health Organization (WHO), projections of cancer prevalence is expected to raise by 21.7 million cases of oncological patients and 13 million deaths by 2030 (El-Azab et al., 2017; Boussari et al., 2018). With the increase in prevalence of cancer and thereby rapidly escalating costs, there are still types of cancer with massive unmet medical needs (Kummar and Takimoto, 2018). Therefore, the development of novel chemotherapeutic agents to fight against this deadly disease is needed urgently (Chakraborty and Rahman, 2012). Nitrogen containing heterocyclic compounds like quinolines and pyridines core rings plays a very important role in drug discovery and development on cancer. (Taylor et al., 2016; Jabir et al., 2018) Some of the marketed drugs have core structure of quinazoline which includes Afatinib (I,

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Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies

Cited by 39 publications

References 51 publications

Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents

Synthesis and biological evaluation of novel quinolone derivatives dual targeting histone deacetylase and tubulin polymerization as antiproliferative agents

Antityrosinase mechanism of ellagic acid in vitro and its effect on mouse melanoma cells

Design, One Pot Synthesis and Molecular Docking Studies of Substituted-1H-Pyrido[2,1-b] Quinazolines as Apoptosis-Inducing Anticancer Agents

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