Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice

Shen, Tong; Dai, Kai; Yu, Yuanman; Wang, Jing; Liu, Changsheng

doi:10.1016/j.actbio.2020.09.035

Cited by 102 publications

(73 citation statements)

References 62 publications

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“…It has been shown that wound healing is faster under a wet environment due to the greater mobility of the extracellular matrix components (Liu et al, 2018;Nethi et al, 2019;Son et al, 2019). Additionally, hydrogels may be peeled off without any damage to the regenerated surface obviating trauma to the patient (Shen et al, 2020;Zhao et al, 2020a).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

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This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from $10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be $38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

et al. 2021

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“…Macrophages are immune cells with a variety of functions and can be divided into M1 type and M2 type according to their activation state and function ( Shen et al, 2020 ). M1 macrophages possess enhanced anti-inflammatory ability, secrete pro-inflammatory cytokines (such as TNF-α, IL-1, IL-6, and IL-23), and arouse ROS, while M2 macrophages can inhibit pro-inflammatory cytokines and secrete extracellular matrix components that may be necessary for the late stage of tissue repair ( Chen et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

et al. 2021

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Overexpression of reactive oxygen species (ROS) can lead to chronic inflammation, which limits skin wound healing. Therefore, it is of great significance to develop materials that can locally control the adverse reactions caused by excessive ROS. In this research, an ROS-sensitive hydrogel with strong free radical scavenging ability was prepared by introducing the thione (Tk) group into carboxymethyl chitosan (CMCTS) hydrogel. CMCTS hydrogel was cross-linked by NH2-Tk-NH2 agent and loaded curcumin (Cur), which possessed favorable nontoxicity, water absorption, mechanical property, biodegradability, drug release behavior, the M2 phenotype, and inflammatory factor regulating the capacity of macrophages. It is worth noting that Cur@CMCTS-Tk hydrogel can significantly inhibit oxidative damage of human fibroblasts in the H2O2-induced microenvironment and protect their viability by reducing the production of intracellular ROS. In vivo, ROS-removing hydrogel effectively accelerated the process of wound healing and possessed good regenerative properties, including hair follicle formation, promotion of new blood vessel formation, and highly orderly arrangement of collagen fibers in the full-thickness skin burn defect rat model. Hence, we expect that the Cur@CMCTS-Tk hydrogel could be used for wound treatment and tissue regeneration due to the ability to scavenge excess ROS.

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“…Shen et al prepared sulfated chitosan-doped I-sexual collagen hydrogels that enhanced macrophage polarization from M1 to M2. Stimulation of macrophage secretion of IL-4 and TGF-β1 enhanced collagen deposition, regenerative epithelialization, and neovascularization [ 54 ].…”

Section: Chitosan In Biomedical Applicationsmentioning

confidence: 99%

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

Zhang

et al. 2022

Polymers

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Chitosan is a biodegradable natural polymer derived from the exoskeleton of crustaceans. Because of its biocompatibility and non-biotoxicity, chitosan is widely used in the fields of medicine and agriculture. With the latest technology and technological progress, different active functional groups can be connected by modification, surface modification, or other configurations with various physical, chemical, and biological properties. These changes can significantly expand the application range and efficacy of chitosan polymers. This paper reviews the different uses of chitosan, such as catheter bridging to repair nerve broken ends, making wound auxiliaries, as tissue engineering repair materials for bone or cartilage, or as carriers for a variety of drugs to expand the volume or slow-release and even show potential in the fight against COVID-19. In addition, it is also discussed that chitosan in agriculture can improve the growth of crops and can be used as an antioxidant coating because its natural antibacterial properties are used alone or in conjunction with a variety of endophytic bacteria and metal ions. Generally speaking, chitosan is a kind of polymer material with excellent development prospects in medicine and agriculture.

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Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice

Cited by 102 publications

References 62 publications

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

ROS-Eliminating Carboxymethyl Chitosan Hydrogel to Enhance Burn Wound-Healing Efficacy

Application of Chitosan and Its Derivative Polymers in Clinical Medicine and Agriculture

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