Sulfated modification of the polysaccharides from Ganoderma atrum and their antioxidant and immunomodulating activities

Chen, Yi; Zhang, Hui; Wang, Yuanxing; Nie, Shaoping; Li, Chang; Xie, Mingyong

doi:10.1016/j.foodchem.2014.10.032

Cited by 124 publications

(65 citation statements)

References 30 publications

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“…The sharp absorption peak at 1259 cm −1 (S–O asymmetry stretching vibration) and 813 cm −1 (C–O–S symmetry stretching vibration) were assigned to the sulfated group in S-CP 1–4 33. The spectral information was similar to the FT-IR spectra of sulfated Ganoderma atrum polysaccharides and Sphallerocarpus polysaccharides183435.…”

Section: Resultsmentioning

confidence: 55%

“…Several polysaccharides were found to have good anti-inflammatory and hepatic activity1516, however, limited by low yield and low activity, it is thus necessary to find a way to strengthen the bioactivities of polysaccharides17. Meanwhile, the introduction of sulfated groups has been reported to significantly improve the bioactivity of polysaccharides, including the antioxidant and anti-inflammatory activities1819. After sulfated modification, modified polysaccharides could better improve inflammatory condition of macrophages through decreasing phagocytosis activity and NO production15.…”

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confidence: 99%

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Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Wang

Xie

Yang

et al. 2017

Sci Rep

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Natural polysaccharides and their modified derivatives are crucial supplements to the prevention of inflammation. This study aimed to evaluate the effect of sulfated modification on the anti-inflammatory and anti-oxidative activities of Cyclocarya paliurus polysaccharides (CP). A sulfated CP, S-CP1–4 was obtained using chlorosulfonic acid-pyridine method. The chemical components and FT-IR spectrum confirmed that sulfated group was synthesized to the polysaccharide chains successfully. S-CP1–4 was found to inhibit nitric oxide production, phagocytic activity and the release of interleukin (IL)-6 and IL-1β in lipopolysaccharide-treated macrophage cells, RAW 264.7. S-CP1–4 significantly decreased the secretion of IL-6 and TNF-α and the thymus and spleen indexes, and increased the production of IL-10 in lipopolysaccharide-treated mice. S-CP1–4 could better protect the liver by inhibiting the activities of alanine aminotransferase and aspartate aminotransferase, and malondialdehyde level while increasing the superoxide dismutase activity and total anti-oxidative capacity. These results suggested that S-CP1–4 may be an effective anti-inflammatory agent, and sulfated modification may be a reliable method for the development of food supplements.

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Section: Resultsmentioning

confidence: 55%

mentioning

confidence: 99%

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Wang

Xie

Yang

et al. 2017

Sci Rep

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“…Triterpenoids (Gt-TRE) and polysaccharide (Gt-PS) extracts from G. tsugae shows anti-allergic effects. Gt-TRE significantly suppressed histamine secreted from activated RBL-2H3 mast cells and interleukin-(IL-) 4 secreted from activated EL4 cells but not Gt-PS (Chen et al 2015). Moreover, triterpenoids fraction of G. tsugae might be the main constituents to alleviate allergic asthma.…”

Section: Ganoderma Tsugaementioning

confidence: 99%

“…Zhu et al (2014) revealed that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway. Ganoderma atrum sulfated polysaccharides with C-2 position (S-PSG-2) derived could be served as immunomodulator and free-radical inhibitors (Chen et al 2015). Huang et al (2016a) revealed that PSG-1stimulated macrophages resulted in an increase in phosphorylation of NF-κB, Akt and MAPK family proteins, which are indicative of activations of NF-κB pathway activation.…”

Section: Ganoderma Atrummentioning

confidence: 99%

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Hapuarachchi¹

2017

Mycosphere

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The genus Ganoderma (Ganodermataceae) has a long history in traditional medicine to improve longevity and health in Asia. Ganoderma has been widely used in multiple therapeutic activities as well as dietary supplements to prevent and treat many diseases. Several classes of bioactive substances have been isolated and identified from Ganoderma, such as polysaccharides, triterpenoids, nucleosides, sterols, fatty acids, protein and alkaloids. There are numerous research publications, which report the abundance and variety of biological actions initiated by the metabolites of Ganoderma. Investigation on different metabolic activities of Ganoderma species has been performed both in vitro and in vivo. In many cases, however, it has been questioned whether Ganoderma is solely a nourishment supplement for wellbeing or merely a helpful "medication" for restorative purposes. There has been no any conclusive report of human trials using Ganoderma species as a direct control agent for diseases. In addition, there is no evidence supporting the usage of Ganoderma species (excluding G. lucidum) as potential supplements for cancer or other diseases in humans since no preclinical trials have been performed up to date. In this review, the beneficial medicinal properties of several species of Ganoderma (excluding G. lucidum) and their secondary metabolites are discussed. Ganoderma species can be used as a therapeutic drug, but more direct scientific evidence should be made available in the future. The efficiency of Ganoderma in clinical treatments should be substantiated with more biomedical research and their true impact assessed on human health with more standardized clinical evaluations so that the feasibility of biologically active extracts of Ganoderma species in alternative treatments can be recommended.

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“…Sulfation reagent를 이용하는 기존의 방법을 수정 하여 수용성 다당을 추출하였다 [9]. 간략히 기술하 Specific activity (μmole/g/min) was estimated as a value for the removal activity of free radical (μmole) per total carbohydrates (g) per reaction time.…”

Section: 황산화 과정을 이용한 수용성 다당 추출unclassified

Antioxidant and Antibacterial Activity of Water Soluble Polysaccharide from Defatted Botryococcus braunii

Lee¹,

Park

2015

Journal of Marine Bioscience and Biotechnology

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Sulfated modification of the polysaccharides from Ganoderma atrum and their antioxidant and immunomodulating activities

Cited by 124 publications

References 30 publications

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Sulfated Cyclocarya paliurus polysaccharides markedly attenuates inflammation and oxidative damage in lipopolysaccharide-treated macrophage cells and mice

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Antioxidant and Antibacterial Activity of Water Soluble Polysaccharide from Defatted Botryococcus braunii

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