Sulfated modification of the water-soluble polysaccharides from Polyporus albicans mycelia and its potential biological activities

Effect of Sulfated Modification on the Molecular Characteristics and Biological Activities of Polysaccharides fromHypsizigus marmoreus

“…Increased macrophage and splenocyte proliferation have also been observed by treating with sulfated polysaccharides in other studies. 30,31) Macrophage cells are essential for maintaining homeostasis regardless of various external conditions and play a pivotal role in host defense against any type of invading cells, including cancer cells. 32) Activated macrophages release such cellular factors as NO, IL-1, TNF-, reactive oxygen intermediates and other substances to kill and inhibit cancer cell growth.…”

“…Significantly low NO production (4 mM) was observed in the presence of sulfated polysaccharide sF9. Sun et al 30) have reported that, within a group of sulfated polysaccharides with a DS range of 0.46 to 0.78, the DS values were directly correlated with their ability to activate macrophages. It is therefore not clear why treating with sulfated polysaccharide sF9, which had the highest DS value, resulted in the low NO production from macrophages, although it may be related to the M w value of this sulfated polysaccharide which is another factor that can affect the release of NO from macrophages.…”

Polysaccharide-Based Anticancer Prodrugs

“…Two CisPt conjugates were obtained by double coordination bond complexation to 60 kDa oxidized Dex (Ox-Dex) (Scheme 5.3, 7) and dicarboxymethylated-Dex (DCM-Dex) (Scheme 5.3,8). First CisPt was converted to cis-diammineplatinum nitrate via reaction with silver nitrate and further to cis-diamminedihydroxyplatinum (CDDP) by anion exchange chromatography.…”

“…Typically, polysaccharides can interact with living cells displaying biological properties such as antioxidant, antimicrobic, antimutant, cell differentiation, anticoagulant, immunostimulant [6][7][8]. Heparins and fucose-containing sulfated polysaccharides, for example, possess blood-anticoagulant activities [9].…”

Extraction, characterization and antitumor effect of the polysaccharides from star anise (Illicium verum Hook. f.)

“…Polysaccharides offer healthy benefits, such as anticancer effects, immuno modulation, anti-bacterial and anti-cardiovascular disease effects (Sonoda et al, 1998;Deters et al, 2005). Similarly, polysaccharide-based treatment regimens have also been shown to be potent immune modulators (Han et al, 2009;Sun et al, 2009) and potentially new options for combating oxidative stress-mediated disorders. Therefore, polysaccharides from various sources have recently emerged as an important class of bioactive natural products (Dourado et *Corresponding author.…”