Sulfated polysaccharide from sea cucumber modulates the gut microbiota and its metabolites in normal mice

Zhu, Zhenjun; Zhu, Beiwei; Sun, Yujiao; Ai, Chunqing; Wu, Sufeng; Wang, Linlin; Song, Shuang; Liu, Xiaoling

doi:10.1016/j.ijbiomac.2018.08.098

Cited by 65 publications

(52 citation statements)

References 52 publications

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“…It showed that HLP-treatment improved SCFAs contents in the feces of the rats. Based on previous studies, HLP may significantly increase the SCFAs-producing capacity of gut microbiota through the activity of key synthetic enzymes and strengthen gene expression [15].…”

Section: Resultsmentioning

confidence: 99%

“…Inflammation is also considered as one of the most innovative concepts in the mechanism. In addition, sea cucumber polysaccharides improve the serum lipid level through the regulation of the expression of lipogenesis-related genes and the ability of gut microbiota to produce SCFAs, thereby improving gut health [15]. Notably, SCFAs play an essential part in the energy source for some bacteria and gut epithelial cells as well as ameliorate serum cholesterol levels.…”

Section: Introductionmentioning

confidence: 99%

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Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

Yuan

Liu

Zhao

et al. 2019

IJMS

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Holothuria leucospilota polysaccharides (HLP) are expected to become potential resources for the treatment of hyperlipidemia because of their various bioactivities. In the study, the treatment of HLP on improving hyperlipidemia in rats was explored. Oral administration of HLP at 100 or 200 mg/kg body weight effectively alleviated serum lipid levels and liver histological abnormalities in high-fat-diet rats. HLP regulated abnormal mRNA, lipogenesis-related hormones and inflammatory cytokines (tumor necrosis factor-α, interleukin-6 and interleukin-12) levels. HLP improved the ability of gut microbiota to produce short-chain fatty acids (SCFAs). SCFAs have been found to ameliorate liver lesions. Therefore, HLP alleviated hyperlipidemia by improving the levels of SCFAs to regulate lipid metabolism. These results indicated that HLP could be used as beneficial polysaccharides to alleviate hyperlipidemia.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

Yuan

Liu

Zhao

et al. 2019

IJMS

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“…Sulfated polysaccharide and its depolymerized derivative from sea cucumber can prevent obesity via modification of gut microbiota in high fat diet (HFD) mice [15]. This polysaccharide also modulated the gut microbiota and its metabolites in normal mice [16]. Fucoidan, a kind of polysaccharide from the sea cucumber Pearsonothuria graeffei , could alleviate gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice [17].…”

Section: Introductionmentioning

confidence: 99%

Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota

Xu²,

Gao

et al. 2019

Marine Drugs

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This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health.

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“…The concentrations of the main SCFAs (e.g., acetate, propionate, and butyrate) were determined according to the method of Zhu et al [38], with slight modifications. Briefly, cecal content (0.3 g) dispersed in cold saline (0.9%, w / w ) was centrifuged at 1006 g for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Physicochemical Properties and Intestinal Health Promoting Water-Insoluble Fiber Enriched Fraction Prepared from Blanched Vegetable Soybean Pod Hulls

Huang

Hsieh

2019

Molecules

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Different methods can be used to change the fiber compositions of food, and they consequently affect the physicochemical properties and physiological activities. The present study compared the effects of a blanching treatment on the physicochemical properties of water-insoluble fiber enriched fraction (WIFF) from three varieties of vegetable soybean pod hulls (tea vegetable soybean pod hull, TVSPH; black vegetable soybean pod hull, BVSPH; 305 vegetable soybean pod hulls, 305VSPH) and evaluated their effects on intestinal health in hamsters. Blanching may increase the soluble dietary fiber (SDF) content of WIFF in the 305VSPH variety by solubilizing cell wall components and releasing water-soluble sugars. Thus, the WIFF in the 305VSPH variety after blanching may be composed of cellulose and pectic substances. The WIFF of the blanched 305VSPH (B-305VSPH) variety exhibited the highest physicochemical properties, such as a water-retention capacity (11.7 g/g), oil-holding capacity (9.34 g/g), swelling property (10.8 mL/g), solubility (12.2%), and cation-exchange capacity (221 meq/kg), of the three varieties examined. The supplementation of B-305VSPH WIFF in the diet resulted in significantly (p < 0.05) lower cecal and fecal ammonia; activities of fecal β-d-glucosidase, β-d-glucuronidase, mucinase, and urease; as well as higher cecal total short-chain fatty acids relative to other diets. In addition, microbial analysis suggested that fecal bifidobacteria growth was enhanced by the consumption of B-305VSPH WIFF. Therefore, B-305VSPH WIFF may be applicable as a potential functional ingredient in the food industry for the improvement of intestinal health.

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Sulfated polysaccharide from sea cucumber modulates the gut microbiota and its metabolites in normal mice

Cited by 65 publications

References 52 publications

Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

Holothuria Leucospilota Polysaccharides Ameliorate Hyperlipidemia in High-Fat Diet-Induced Rats via Short-Chain Fatty Acids Production and Lipid Metabolism Regulation

Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota

Physicochemical Properties and Intestinal Health Promoting Water-Insoluble Fiber Enriched Fraction Prepared from Blanched Vegetable Soybean Pod Hulls

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