Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats

Brito, Tarcísio Vieira de; Barros, Francisco Clark Nogueira; Silva, Renan O.; Júnior, Genilson José Dias; Júnior, José S C; Franco, Álvaro Xavier; Soares, Pedro Marcos Gomes; Chaves, Luciano S.; Abreu, Clara M.W.S.; Paula, Regina C.M. de; Souza, Marcellus H.; Freitas, Ana Lúcia Ponte; Barbosa, André Luiz R.

doi:10.1016/j.carbpol.2016.06.047

Cited by 58 publications

(21 citation statements)

References 47 publications

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“…Some find commercial applications in cosmetics and skin‐care products, emulsifiers, the food industry and medicine . Some sulfated polysaccharides in particular have remarkable medical applications …”

Section: Lipidsmentioning

confidence: 99%

Microalgae cultivation and metabolites production: a comprehensive review

Vuppaladadiyam

Prinsen

Raheem

et al. 2018

Biofuels Bioprod Bioref

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Microalgae have important potential in the bio‐based industry. However, their light‐utilization mechanisms are still not fully understood. Together with knowledge of their metabolic pathways and their responses in carbon partitioning to different primary metabolites (carbohydrates, lipids and proteins), this information is essential if their potential and profitability are to be better exploited. The first part of this review describes the techniques used for microalgae cultivation and the growth factors that determine their productivity, one of the most important factors in techno‐economic assessment studies of microalgae production systems. In the second part, a closer look is taken at their chemical composition in relation to the biosynthesis of primary and secondary metabolites. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd

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Section: Lipidsmentioning

confidence: 99%

Microalgae cultivation and metabolites production: a comprehensive review

Vuppaladadiyam

Prinsen

Raheem

et al. 2018

Biofuels Bioprod Bioref

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“…The [ 13 C]-Spirulina platensis GEBT is an easy to measure of gastric emptying with accuracy [331][332][333]. Laminaria japonica (vomiting, hemorrhoids, IBD, probiotic synergist) [334,335], Eucheuma cottonii (IBD, hepatoprotective, anti-food allergy) [336][337][338], Caulerpa Mexicana (Figure 15) (Gastroprotective, IBD) [339][340][341], Hypnea musciformis (IBD) [336,342], Fucus vesicolosus (gastroprotective, ulcerative colitis) [117,343], Laminaria hyperborean, Laminaria digitate (IBD) [344,345], Undaria pinnatifida ( Figure 16) (improves gut health) are reported in gut health modulation [346]. In addition, seaweed polysaccharides are atypical in structure to terrestrial glycans, and were found to resist gastric acidity, host digestive enzymes, and GI absorption [347].…”

Section: Alimentary Disordersmentioning

confidence: 99%

Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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“…Pharmacological studies have demonstrated that biological compounds derived from red seaweeds act against gastrointestinal disorders such as stomachache (Kazłowska et al 2010). In northeast Brazilian regions, use of red seaweeds and its extracted compounds increased for intestinal inflammatory disorders, such as diarrhea (Sousa et al 2016a;Bezerra et al 2018), gastritis, (Sousa et al 2016b), and colitis (Brito et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

Monturil

Brito

Júnior

et al. 2020

Rev. Bras. Farmacogn.

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Sulfated polysaccharides derived from seaweeds have important biological activities. The aim of this work was to demonstrate the anti-inflammatory effect of a sulfated polysaccharide extracted from the seaweed Digenea simplex (Wulfen) C. Agardh 1822 on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. After inducing colitis, rats were euthanized, and the colon was excised to determine macroscopic lesion scores and wet weight and to histologically evaluate and quantify glutathione, malondialdehyde, myeloperoxidase, nitrate/nitrite, and cytokines. The polysaccharide, composed of β-D-galactose and 3,6-α-L-anhydrogalactose residues, reduced wet weight as well as macroscopic and microscopic lesion scores. It also reduced myeloperoxidase activity; reduced proinflammatory cytokines, malondialdehyde, and nitrate/nitrite levels; and preserved glutathione consumption in the colon. According to these results, we can infer that the sulfated polysaccharide derived from D. simplex has an anti-inflammatory effect on induced colitis in vivo.

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Sulfated polysaccharide from the marine algae Hypnea musciformis inhibits TNBS-induced intestinal damage in rats

Cited by 58 publications

References 47 publications

Microalgae cultivation and metabolites production: a comprehensive review

Microalgae cultivation and metabolites production: a comprehensive review

Seaweeds: An Extensive Review of Medicinal Values

Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

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