Sulfated Purine Alkaloid Glycosides from the Pupal Case Built by the Bruchid Beetle Bruchidius dorsalis Inside the Seed of Gleditsia japonica

Abstract

Three new sulfated isoguanine alkaloid glycosides, designated as saikachinoside A monosulfate (1), saikachinoside A disulfate (2), and locustoside B disulfate (3), have been isolated from the pupal case of the wild bruchid seed beetle Bruchidius dorsalis (Chrysomelidae, Bruchinae) infesting the seed of Gleditsia japonica Miq. (Fabaceae). Their structures were determined by spectroscopic methods and the inhibitory activity of 2 and 3 against acid phosphatase was evaluated.

Nuclear magnetic resonance spectroscopy and mass spectrometry data for sulfated isoguanine glycosides

“…Although some sulfated guanosine analogs, such as the kainate receptor inhibitor HF-7 [2], have been isolated from the venom of spiders [3], sulfated nucleoside derivatives from natural sources other than spiders are rare [1,4].…”

Isolation of Fluorescent Benzoxazines with Neuroprotective Activity from the Olive Weevil Pimelocerus perforatus

“…It is known that pest infestation in olive trees occurred immediately after they were introduced in Japan. − Although its population density in the original host plants is very low, it is significantly higher in olive trees; the adult population can exceed 100 insects per tree. Once infested, the pests feed on the leaves and bark of the olive tree and rapidly increase in population, subsequently killing the tree. , Based on our previous work on biologically active compounds from insects, − two new racemic fluorescent benzoxazines, designated as pimeforazine A ((±)- 1 ) and pimeforazine B ((±)- 2 ), were isolated from P. perforatus . Compounds (±)- 1 and (±)- 2 exhibited neuroprotective activity against H 2 O 2 -induced cellular damage in SH-SY5Y human neuroblastoma cells.…”