Sulfonamide Antibacterial Agents

doi:10.1002/9781118325421.ch5

Antibacterial Agents 2012

DOI: 10.1002/9781118325421.ch5

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Sulfonamide Antibacterial Agents

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Cited by 5 publications

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Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Zhao

Huang

et al. 2018

Angewandte Chemie

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Asymmetric reductive amination of poorly nucleophilic sulfonamides was realized in the presence of nickel catalysts and titanium alkoxide. A wide range of ketones, including enolizable ketones and some biaryl ones, were converted into sulfonamides in excellent enantiomeric excess. The cyclization of sulfamates and intermolecular reductive amination of a diarylphosphinamide were also successful. Formic acid was used as a safe and economic surrogate of high‐pressure hydrogen gas.

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Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Zhao

Huang

et al. 2018

Angewandte Chemie

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Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Zhao

Huang

et al. 2018

Angew Chem Int Ed

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Antibacterial activities of sulfamethoxazolyl-azo-phenols and their Cu(II) complexes along with molecular docking properties

et al. 2017

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Sulfamethoxazolyl-azo-phenols [SMX-N=N-CH(R)(R)-OH] (1a, 2a) and their Cu(II) complexes, [Cu(SMX-N=N-CH(R)(R)-O)] (1b, 2b) (R = p-OMe, R = H, 1a/1b; R = p-Cl, R = m-CH, 2a/2b) show antibacterial sensitivity against Gram-positive bacteria, B. subtillis; IC: 281.47 ± 1.84 μM (1a), 126.39 ± 1.66 μM (1b), and 279.94 ± 3.15 μM (2a), 123.62 ± 1.27 μM(2b), and Gram-negative bacteria, E. coli; IC: 204.66 ± 3.31 μM (1a) and 89.05 ± 1.48 μM (1b), 223.13 ± 2.71 μM (2a), and 98.26 ± 1.59 μM (2b). Interaction of DNA with free ligand (1a and 2a) is insignificant, while the complexes (1b and 2b) interact strongly and the binding constants are K , 8.413 × 10 M (1b) and 6.56 × 10 M (2b). Optimized structures of the compounds are docked with protein structure of DHPS (E. coli) to propose the most favoured binding mode of the drugs in the active site. The in silico test of the compound helps to understand drug metabolism, drug-protein interactions, and toxicity (ADMET).

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Sulfonamide Antibacterial Agents

Cited by 5 publications

References 88 publications

Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Antibacterial activities of sulfamethoxazolyl-azo-phenols and their Cu(II) complexes along with molecular docking properties

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