Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity

Novel heterocyclic ring-fused oleanolic acid derivatives as osteoclast inhibitors for osteoporosis

“…In the present study, as continuing research of our project to further improve the inhibitory effect on osteoclasts, a series of new oleanolic acid derivatives constructed via modifications in the A-ring and C-28 position with heterocycles were designed and synthesized. Because sulfoneextended backbone analogs are known to be associated with a broad spectrum of bioactivity in many drugs, 16 various sulfonyl groups were further introduced into the heterocyclefused A-ring. The inhibitory activity of the synthesized derivatives on osteoclast formation was evaluated in vitro.…”