Sulfonylurea induction of caffeine-enhanced insulin secretion and reduction of glycemic levels in diabetic rats

Abstract

Acute caffeine intake with exercise can increase glucose uptake enhancing insulin secretion stimulated by sulfonylurea in β cells-deficient pancreas. The results indicate the potential use of caffeine as a strategy for glycemic and insulin control in diabetes.

Baccharis dracunculifoliamethanol extract enhances glucose-stimulated insulin secretion in pancreatic islets of monosodium glutamate induced-obesity model rats

“…In the experimental field, different studies with different models that mimic the clinical signs of diabetes (streptozotocin, alloxan, monosodium glutamate, Zucker diabetic fatty rats, and ob/ob) contribute promoting new-supporting procedures and therapies to the treatment of diabetes. Among these new approaches, the use of natural products such as propolis (Ueda et al, 2013), Baccharis (Lemos et al, 2007), caffeine (Akash et al, 2013c;Silva et al, 2014), and specific components of medicinal plants such as artelipin C, flavonoids, phenolic compounds, and coumarins (Marcucci et al, 2001) have been promising.…”