Sulfonylurea receptor–associated channels

Benarroch, Eduardo E.

doi:10.1212/wnl.0000000000003523

Cited by 5 publications

(2 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the downregulation of piRNAs target to IL6R can allow the expression of IL6R in the membrane of pro-regenerative macrophages. This receptor is necessary for the effective action of IL-6 that has been described in patients with higher titers 18 , 19 and as a marker of neuropathic pain in patients with leprosy 20 . Therefore, IL-6 may be related to bette nerve regeneration in addition to the stimulation of a more efficient cellular response under the auspices of a downregulated piRNA profile.…”

Section: Discussionmentioning

confidence: 99%

Leprosy piRnome: exploring new possibilities for an old disease

Pinto¹,

Silva²,

Moreira³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Leprosy, which is caused by the human pathogen Mycobacterium leprae , causes nerve damage, deformity and disability in over 200,000 people every year. Because of the long doubling time of M. leprae (13 days) and the delayed onset of detectable symptoms, which is estimated to be approximately 3–7 years after infection, there is always a large percentage of subclinically infected individuals in the population who will eventually develop the disease, mainly in endemic countries. piRNAs comprise the largest group of small noncoding RNAs found in humans, and they are distinct from microRNAs (miRNAs) and small interfering RNAs (siRNAs). piRNAs function in transposon silencing, epigenetic regulation, and germline development. The functional role of piRNAs and their associated PIWI proteins have started to emerge in the development of human cancers and viral infections, but their relevance to bacterial diseases has not been investigated. The present study reports the piRNome of human skin, revealing that all but one of the piRNAs examined are downregulated in leprosy skin lesions. Considering that one of the best characterized functions of piRNAs in humans is posttranscriptional mRNA silencing, their functions are similar to what we have described for miRNAs, including acting on apoptosis, M. leprae recognition and engulfment, Schwann cell (SC) demyelination, epithelial–mesenchymal transition (EMT), loss of sensation and neuropathic pain. In addition to new findings on leprosy physiopathology, the discovery of relevant piRNAs involved in disease processes in human skin may provide new clues for therapeutic targets, specifically to control nerve damage, a prominent feature of leprosy that has no currently available pharmaceutical treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Leprosy piRnome: exploring new possibilities for an old disease

Pinto¹,

Silva²,

Moreira³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Mutations that alter K ATP channel activity are commonly seen in patients with neonatal diabetes, hyperinsulinemia and developmental delay-epilepsy-neonatal diabetes (DEND syndrome) 144 , 145 , 146 , 147 . Specifically, mutations in SUR subunit are associated with diabetes 148 . K ATP channels and SUR modulatory subunits act as key drug targets for diabetes hyperglycemic control.…”

Section: K Atp Channel Blockers In Diabetes Treatmmentioning

confidence: 99%

The role of KATP channels in cerebral ischemic stroke and diabetes

et al. 2018

View full text Add to dashboard Cite

ATP-sensitive potassium (KATP) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain. KATP channels play important roles in controlling and regulating cellular functions in response to metabolic state, which are inhibited by ATP and activated by Mg-ADP, allowing the cell to couple cellular metabolic state (ATP/ADP ratio) to electrical activity of the cell membrane. KATP channels mediate insulin secretion in pancreatic islet beta cells, and controlling vascular tone. Under pathophysiological conditions, KATP channels play cytoprotective role in cardiac myocytes and neurons during ischemia and/or hypoxia. KATP channel is a hetero-octameric complex, consisting of four pore-forming Kir6.x and four regulatory sulfonylurea receptor SURx subunits. These subunits are differentially expressed in various cell types, thus determining the sensitivity of the cells to specific channel modifiers. Sulfonylurea class of antidiabetic drugs blocks KATP channels, which are neuroprotective in stroke, can be one of the high stoke risk factors for diabetic patients. In this review, we discussed the potential effects of KATP channel blockers when used under pathological conditions related to diabetics and cerebral ischemic stroke.

show abstract

Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets

Song

2017

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

Sulfonylurea receptor–associated channels

Cited by 5 publications

References 73 publications

Leprosy piRnome: exploring new possibilities for an old disease

Leprosy piRnome: exploring new possibilities for an old disease

The role of KATP channels in cerebral ischemic stroke and diabetes

Disrupted Ionic Homeostasis in Ischemic Stroke and New Therapeutic Targets

Contact Info

Product

Resources

About