Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines

Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates: Focus on glucoraphanin

“…P-glycoprotein and Multidrug Resistance Protein 2 (MRP2), that secrete xenobiotics and metabolites out of the enterocyte into the gut lumen for fecal excretion (Ford & Hait, 1990). Both SF and ER were found to upregulate synthesis of MRP2 in cultured enterocytes (Harris & Jeffery, 2008;Jakubikova, Sedlak, Mithen, & Bao, 2005). It remains to be seen if SF secretion is via MRP2 and if any bioactive food components or xenobiotics seem to cause synergy with SF, such as quercetin (Srivastava, Tang, Zhu, Meeker, & Shankar, 2011) might do so by blocking SF secretion by transporters, either from the enterocyte into the gut or from other tissues.…”

Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells

“…Other potential targets include kinases, transcriptional factors, transporters and receptors [21][22][23][24]. Since both Nrf2 and TrxR-1 can play dual roles in cancer [25][26][27][28] glutamine, penicillin (100 U/ml) and streptomycin (100µg/ml) under 5% CO 2 in air at 37 o C.…”

Antiproliferative Activity of the Dietary Isothiocyanate Erucin, a Bioactive Compound from Cruciferous Vegetables, on Human Prostate Cancer Cells

“…Literature data present current knowledge on the potential antiproliferative activity of ER in several cultured cancer cell lines, such as lung, liver, colon, and leukaemia cells (11,(15)(16)(17). However, there is no evidence of its effects on human prostate cancer cells to date.…”