Sulfoxaflor insecticide exhibits cytotoxic or genotoxic and apoptotic potential via oxidative stress-associated DNA damage in human blood lymphocytes cell cultures

Sınacı, Cebrail; Çelık, Ayla; Yetkin, Derya; Çevik, Sertan; Güler, Gizem

doi:10.1080/01480545.2022.2114006

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…However, SFX has been detected in the environment in recent years with increasing frequency and scope because of its refractory and permeable nature and endosomatic conductivity . SFX was initially touted as a low-toxicity pesticide; however, it can also threaten human health and lead to adverse environmental impacts on nontarget organisms. , With prolonged exposure, SFX is highly toxic to earthworms; compared with the control group, the SFX-exposed group exhibits dramatically increased oxidative properties . SFX is also highly toxic to Trichogrammatidae (Trichogramma dendrolimi, Trichogramma ostriniae, and Trichogramma confusum), an extremely potent and effective biological control against a broad spectrum of worm infestations.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Daphnia magna

Yuan

Jiao

et al. 2023

J. Agric. Food Chem.

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Sulfoxaflor is a promising neonicotinoid. However, the negative implications of sulfoxaflor on nontarget aquatic organisms have been rarely studied. In this study, the risks of sulfoxaflor and its main metabolites X11719474 and X11519540 on Daphnia magna were characterized, including acute toxicity, reproduction, swimming behavior, biochemical markers, and gene transcription. Acute toxicity measurements indicated that X11719474 and X11519540 have high toxicity than the parent compound sulfoxaflor. Chronic exposure reduced reproduction and delayed the birth of the firstborn D. magna. Swimming behavior monitoring showed that exposure to three compounds stimulated swimming behavior. The induction of catalase, superoxide dismutase, and acetylcholinesterase activities was observed with oxidative stress, whereas malondialdehyde content was remarkably increased with exposure to sulfoxaflor, X11719474, and X11519540. Moreover, transcriptomics profiles showed that sulfoxaflor, X11719474, and X11519540 induced KEGG pathways related to cellular processes, organismal systems, and metabolisms. The findings present valuable insights into the prospective hazards of these pesticides and emphasize the critical importance of conducting a systematic evaluation of combining antecedents and their metabolites.

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Section: Introductionmentioning

confidence: 99%

Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Daphnia magna

Yuan

Jiao

et al. 2023

J. Agric. Food Chem.

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“…This is the rst research to show that sulfoxa or causes oxidative DNA damage and activates DNA damage genes at the transcriptional level. Sulfoxa or has been shown to produce genotoxicity and apoptosis in human blood lymphocytes via oxidative stress-associated DNA damage(Sinaci et al 2023). Previous studies demonstrated that neonicotinoids have a genotoxic effect by inducing DNA damage.…”

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confidence: 99%

Regulatory Role of Sulfated Polysaccharides Fucoidan from Fucus vesiculosus against Oxidative and Transcriptional Responses in liver of sulfoxaflor exposed mice: assessment of DNA damage, DNA damage repair genes (XRCC1, OGG1, APE1, and PARP1) and antioxidant status

BENLI,

DAGLIOGLU,

COSKUN

2024

Preprint

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This research aimed to determine regulatory role of sulfated polysaccharides fucoidan from Fucus vesiculosus against oxidative and transcriptional responses in liver of sulfoxaflor exposed mice liver. Fort this purpose both sulfoxaflor and fucoidan were given orally to mice for 24 hours and 7 days at doses of 15 mg/kg/day (equivalent to 1/50 oral LD50) and 50 mg/kg/day. At the end of the tests, liver samples were collected and used to assess 8-OHdG levels, the mRNA expression levels of DNA damage response genes such as XRCC1, OGG1, APE1, and PARP1. Furthermore, levels of tGSH and enzyme activity of GPx, GR, and GST, as well as TBARS, were also examined. The results showed that sulfoxaflor caused oxidative responses via increasing 8-OHdG and TBARS levels and altering antioxidant status in the liver. Furthermore, sulfoxaflor increased the mRNA expression of XRCC1 and APE1 genes, which are involved in the DNA repair mechanism. It was discovered that fucoidan protected liver cells against sulfoxaflor-induced DNA damage and lipid peroxidation by activating the tGSH and GPx, GR, GST. Additionally, it had a regulatory role in the liver of mice, affecting the mRNA expression of XRCC1 and APE1.

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Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats

Tijani,

Daba,

Ubong

et al. 2023

Drug and Chemical Toxicology

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Sulfoxaflor insecticide exhibits cytotoxic or genotoxic and apoptotic potential via oxidative stress-associated DNA damage in human blood lymphocytes cell cultures

Cited by 4 publications

References 35 publications

Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Daphnia magna

Characterization of Sulfoxaflor and Its Metabolites on Survival, Growth, Reproduction, Biochemical Markers, and Transcription of Genes of Daphnia magna

Regulatory Role of Sulfated Polysaccharides Fucoidan from Fucus vesiculosus against Oxidative and Transcriptional Responses in liver of sulfoxaflor exposed mice: assessment of DNA damage, DNA damage repair genes (XRCC1, OGG1, APE1, and PARP1) and antioxidant status

Co-administration of thymol and sulfoxaflor impedes the expression of reproductive toxicity in male rats

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