Sulfur-oxidation enhances nitrile hydration in bioinspired ruthenium complexes : catalytic, kinetic, and DFT investigations.

Kumar, D. Nagesh

doi:10.18297/etd/2098

Cited by 3 publications

(2 citation statements)

References 118 publications

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“…In modern biology, cellular regulatory processes where post-translational oxygenation of the cysteine-derived sulfur donors with a combination of thiolate (RS -), sulfenate (RSO -), and sulfinate (RSO 2 -) in the active site of NHase to iron(III) was reported. [27][28][29][30] Again mimicking the active site of such types of valuable enzymes incorporated the oxygenates of sulfur ligands achieved by numerous model complexes synthesis. [31][32][33] In recent time, an array of transition metal mediated sulfur oxygenates like sulfenate, sulfinate and sulfonates have been synthesized mostly by chemical methods and also photochemical and/or electrochemically oxidation processes from the corresponding thiolates.…”

Section: Introductionmentioning

confidence: 99%

Sulfur-center Reactivity toward Oxygenation Mediated by Ruthenium: Effective Bioactive Compounds (A Review)

Das¹

2022

Orient. J. Chem

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Transition metal mediated thiolato compounds are highly vulnerable for S-centered oxidation due to its high nucleophilicity and which is immensely important in the point of its bio-activity. It is generally noticeable that a range of chemical changes occurred with molecular O2 and ruthenium thiolato metalloligands in varying conditions. These oxygenations are facile under strictly oxygen environment and produce mono and di sulfenato and/or sulfinato depending on the substrate thiolato. The numerous heteroatomic substituents of thiolato-S ligand have performed a vital task during the course of oxygenation producing oxygenated products as sulfenates, sulfinates and sulfones. There appear to be numerous mechanisms that are involved in the oxygenation process are considerably more complex. Some bizarre photo-induced S-center oxygenation of metal-thiolato to the sulfonated compound is also mentioned. The ruthenium sulfur compounds jointly with the S-oxygenates show remarkable bioactivity as well as enzymatic catalytic activity and interaction with the bio-molecules like DNA that opens a new theme for the researcher for design novel Ru-sulfur-oxygenates compounds as metallodrugs.

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Section: Introductionmentioning

confidence: 99%

Sulfur-center Reactivity toward Oxygenation Mediated by Ruthenium: Effective Bioactive Compounds (A Review)

Das¹

2022

Orient. J. Chem

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“…Also, to have a better insight of the structure stability and reaction mechanisms, the computational modelling done using various available functional and basis sets gives us better understanding of the reaction pathway of the system. The theoretical methods used to perform the computational modelling can be divided into following categories 82. 1) ab-initio method: This method as the name suggests, is indicative of the beginning.…”

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confidence: 99%

Evaluating ligand assisted activation of small molecules through proton reduction and alcohol oxidation.

Jain¹

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Platinum Group Metals Bonded Thiolato Sulfur Oxygenation: Photoactivity and Bioactivity

Das¹

2022

Asian J. Chem.

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Platinum group metals mediated thiolato compounds are highly susceptible for S-centered reactivity owing to high nucleophilicity and which is enormously significant in the point of its bioactivity and photoactivity. A series of oxygenation reactions of thiolate sulfur attached with platinum metals occurred with molecular O2 in varying conditions. A variety of sulfenates and sulfinates are produced depending on nature of starting substrate thiolato and the oxygenations are facile under harshly oxygen environment. There are numerous mechanistic paths for the oxygenation of platinum metals bonded thiolate S-center unlike the oxygenation reaction of organic sulphides. It is assumed that S-oxygenation occurs via the intramolecular and intermolecular dioxygen addition pathways. A number of mysterious photo-induced sulphur oxygenation and self-sensitization reactions of metal-thiolato to analogous oxygenate are also mentioned. These compounds show enzymatic catalytic activity and remarkable bioactivity also interaction with the biomolecules like DNA, which opens a new area for the researchers for designing novel heavier metals-sulfur-oxygenates compounds as metallodrugs.

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Sulfur-oxidation enhances nitrile hydration in bioinspired ruthenium complexes : catalytic, kinetic, and DFT investigations.

Cited by 3 publications

References 118 publications

Sulfur-center Reactivity toward Oxygenation Mediated by Ruthenium: Effective Bioactive Compounds (A Review)

Sulfur-center Reactivity toward Oxygenation Mediated by Ruthenium: Effective Bioactive Compounds (A Review)

Evaluating ligand assisted activation of small molecules through proton reduction and alcohol oxidation.

Platinum Group Metals Bonded Thiolato Sulfur Oxygenation: Photoactivity and Bioactivity

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