Sulfur-vacancy-enriched MoS2-CNTs with highly dispersed Au particles for sensitive dopamine detection

Hua, Hefei; Chen, Beibei; Ji, Zhiheng; Wang, Juan

doi:10.1016/j.apsusc.2023.158244

Cited by 6 publications

(1 citation statement)

References 53 publications

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“…In addition, to ensure sufficient sensitivity of electrochemical immunosensors, many efforts have been made to improve the electrochemical response towards the electrochemical probe by modifying various nanomaterials on the electrodes, such as carbon nanomaterials [ 17 ], metal and nonmetallic nano-oxides [ 18 , 19 ] and noble metal nanoparticles [ 20 ]. Amongst them, metal sulfides display great potential for signal amplification, due to their properties of good catalytic activity and good biocompatibility [ 21 , 22 ]. Tungsten disulfide (WS 2 ) is a 2D-layered graphene-like material, which, due to its electrochemical properties, sheet-like architecture and high surface area, has attained much attention from researchers.…”

Section: Introductionmentioning

confidence: 99%

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

Wang,

Tang,

Zhou

et al. 2024

Molecules

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Thyroid transcription factor 1 (TTF1) is an important cancer-related biomarker for clinical diagnosis, especially for carcinomas of lung and thyroid origin. Herein, a novel label-free electrochemical immunosensor was prepared for TTF1 detection based on nanohybrids of ribbon-like tungsten disulfide-reduced graphene oxide (WS2-rGO) and gold nanoparticles (AuNPs). The proposed immunosensor employed H2O2 as the electrochemical probe because of the excellent peroxidase-like activity of ribbon-like WS2-rGO. The introduction of AuNPs not only enhanced the electrocatalytic activity of the immunosensor, but also provided immobilization sites for binding TTF1 antibodies. The electrochemical signals can be greatly amplified due to their excellent electrochemical performance, which realized the sensitive determination of TTF1 with a wide linear range of 0.025–50 ng mL−1 and a lower detection limit of 0.016 ng mL−1 (S/N = 3). Moreover, the immunosensor exhibited high selectivity, good reproducibility, and robust stability, as well as the ability to detect TTF1 in human serum with satisfactory results. These observed properties of the immunosensor enhance its potential practicability in clinical applications. This method can also be used for the detection of other tumor biomarkers by using the corresponding antigen–antibody complex.

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