Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: A randomized trial to guide national policy

Nsimba, Basile; Guiyedi, Vincent; Mabika-Mamfoumbi, Modeste; Mourou-Mbina, J.R.; Ngoungou, Edgard Brice; Bouyou-Akotet, Marielle Karine; Loembet, Romaric; Durand, Rémy; Bras, J. Le; Kombila, Maryvonne

doi:10.1186/1475-2875-7-31

Cited by 27 publications

(19 citation statements)

References 22 publications

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“…Data on the efficacy of sulfadoxine-pyrimethamine in children showed a therapeutic efficacy rate of 88.4% at day 28 in 2005. 10 This study was reviewed and approved by the Gabonese Ministry of Health.…”

Section: Methodsmentioning

confidence: 99%

Burden of Malaria during Pregnancy at the Time of IPTp/SP Implementation in Gabon

Bouyou-Akotet¹,

Nzenze-Afene²,

Ngoungou³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. The new recommendations to prevent malaria in pregnant women have recently been implemented in Gabon. There is little information on the pregnancy indicators that are useful for their evaluation. A cross-sectional study for the assessment of the prevalence of peripheral, placental, and cord malaria and anemia among delivering women was performed at the largest public hospital of Gabon. Malaria prevalence was 34.4%, 53.6%, and 18.2% for maternal peripheral, placental, and cord blood respectively, with no difference between primigravidae and multigravidae. Submicroscopic infections were frequent and concerned all the positive cord samples. Maternal peripheral, late placental, and cord infections were all associated with a reduced mean birth weight in primigravidae ( P = 0.02). Anemia prevalence was 53%, low birth rate was 13%, and prematurity was 25%. The use of intermittent preventive treatment with sulfadoxinepyrimethamine (greater than or equal to one dose) combined with bed net was associated with a reduction in infection only in multigravidae and with a reduced risk of maternal anemia.

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Section: Methodsmentioning

confidence: 99%

Burden of Malaria during Pregnancy at the Time of IPTp/SP Implementation in Gabon

Bouyou-Akotet¹,

Nzenze-Afene²,

Ngoungou³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…Furthermore, an increase of asexual parasites and gametocytes harboring the Pfmdr1 NFD haplotype in patients treated with AL was linked with treatment failure [19]. and the resistance to CQ, amodiaquine and sulfadoxinepyrimethamine is widespread [20][21][22][23]. In 2003, in line with WHO recommendations, the National Malaria Control Program adopted the ACT strategy to treat uncomplicated malarial spraying, instead of CQ and other monotherapies.…”

Section: Introductionmentioning

confidence: 98%

“…The ACTs most widely used in Gabon are artemether-lumefantrine (AL) and artesunate-amodiaquine (AS-AQ). Consequently, the prevalence of malaria among febrile children fell from 30% to 13% between 2004 and 2008, the mean age of children with malaria rose from 24 to 41 months [21,7]. Later, in 2013, several studies demonstrated the rise of malaria in urban areas of the country (Libreville, Oyem and Franceville) [24,25].…”

Section: Introductionmentioning

confidence: 99%

Pfmdr1 gene polymorphism of Plasmodium falciparum isolates from asymptomatic individuals of Dienga, southeastern Gabon

Pegha-Moukandja¹,

Kouna²,

Maghendji-Nzdondo³

et al. 2018

J Parasitic Diseases

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“…Data were collected from children aged six months to 10 years suffering from uncomplicated malaria who took part in two clinical trials performed between 2005 and 2006 as described elsewhere (Bouyou-Akotet et al, 2010;Nsimba et al, 2008). These patients were treated either with amodiaquine (AQ), sulfadoxinepyrimethamine (SP) or artesunate-mefloquine (AM) according to their age and/or weight following World Health Organization (WHO) guidelines.…”

Section: Study Populationmentioning

confidence: 99%

Altered total cholesterol and triglyceride levels during the course of Plasmodium falciparum infection in children

Bouyou-Akotet¹,

Mboumba²,

Guiyedi³

et al. 2014

J. Parasitol. Vector Biol.

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Changes of lipid parameter concentrations are observed in patients suffering from malaria. However, there are few data on their evolution during the course of the infection and their relationship with the infection parameters. The levels of triglycerides (TG) and total cholesterol (TC) were measured during and after uncomplicated Plasmodium falciparum malaria in 122 children. The relationship with the antimalarial drug treatment, the parasite density and haemoglobin levels was also assessed. Mean TG levels were high before the treatment (1.9 ± 1.2 mmol/L) and at day 3 post-treatment (2.3 ± 1.3 mmol/L), then subsequently decreased to reach normal level from day 7. A negative correlation was found between haemoglobin (Hb) levels and TG (rho = -0.47; p < 0.01); previous high parasitaemia at inclusion was associated with a subsequent increase of TG levels after treatment administration. The majority of patients with hypertriglyceridemia were anaemic at day 3 (n = 20/20) and at day 7 (n = 18/19). Only 5 (4.1%) patients had hypertriglyceridemia at day 28. A trend toward a negative correlation between TC levels and parasite density was observed (rho = -0.18; p = 0.05). Mean TC concentration was significantly lower at day 0 when all the patients were parasitaemic (3.0 ± 1.0 mmol/L) compared to day 3 (3.7 ± 1.2 mmol/L) (p = 0.01). Mean CT was low during the first week and at day 28, 71 (58.2%) children still had a subnormal CT levels. No relationship was found with the type of antimalarial drug. Transient hypertriglyceridemia and hypocholesterolemia are observed during the course of P. falciparum infection. High TG levels seem to be related to the malaria related haemolysis.

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Sulphadoxine/pyrimethamine versus amodiaquine for treating uncomplicated childhood malaria in Gabon: A randomized trial to guide national policy

Cited by 27 publications

References 22 publications

Burden of Malaria during Pregnancy at the Time of IPTp/SP Implementation in Gabon

Burden of Malaria during Pregnancy at the Time of IPTp/SP Implementation in Gabon

Pfmdr1 gene polymorphism of Plasmodium falciparum isolates from asymptomatic individuals of Dienga, southeastern Gabon

Altered total cholesterol and triglyceride levels during the course of Plasmodium falciparum infection in children

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