1992
DOI: 10.1042/cs0830623
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Sulphation of colonic and rectal mucin in inflammatory bowel disease: reduced sulphation of rectal mucus in ulcerative colitis

Abstract: 1. Normal colonic mucin is heavily sulphated and this increases its resistance to degradation by bacterial enzymes. Any defect in mucus sulphation could therefore be important in the pathogenesis of ulcerative colitis. 2. Rectal biopsies taken at colonoscopy from patients with ulcerative colitis (n = 9), patients with Crohn's disease (n = 6) and control subjects (n = 16) were cultured for 24 h in the presence of N-[3H]acetylglucosamine and [35S]sulphate. Mucin was then extracted and purified, and the ratio of … Show more

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Cited by 113 publications
(87 citation statements)
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“…Now that MUC3A is shown to be a membrane-bound mucin, the increased risk of UC in those who have one or two rare alleles of MUC3A is easy to understand because of the limited expression of the protein within the cell membrane. Normal colonic mucin is heavily sulfated, a feature that prevents degradation by bacterial proteases, and the significant loss of mucin sulfation observed in patients with UC (Raouf et al 1992) may also be related to the underglycosylation of MUC3A protein.…”
Section: Discussionmentioning
confidence: 99%
“…Now that MUC3A is shown to be a membrane-bound mucin, the increased risk of UC in those who have one or two rare alleles of MUC3A is easy to understand because of the limited expression of the protein within the cell membrane. Normal colonic mucin is heavily sulfated, a feature that prevents degradation by bacterial proteases, and the significant loss of mucin sulfation observed in patients with UC (Raouf et al 1992) may also be related to the underglycosylation of MUC3A protein.…”
Section: Discussionmentioning
confidence: 99%
“…142 The MUC2 produced, however, has an altered structure as the oligosaccharide chain length is reduced by about 50%. 143 The overall effect of this is that, even though there is increased MUC2 output, the altered structure leads to loss of its viscoelastic properties and a reduced barrier function. In UC however, the mucus layer is thin due to decreased MUC2 production and secretion.…”
Section: Er Stress and Mucin Regulation In Ibdmentioning
confidence: 99%
“…These changes alter the properties of the viscous mucous gel and influence the interactions of mucins with micro-organisms and defensive proteins, therefore reducing the protective abilities of the mucous layer (Raouf et al, 1992). Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are associated with defective MUC genes causing an altered mucosal barrier (McAuley et al, 2007;McGuckin et al, 2007).…”
Section: Introductionmentioning
confidence: 99%