Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Kuprys, Paulius V.; Tsukamoto, Hidekazu; Gao, Bin; Lin, Jen‐Der; McGowan, Jacob D.; Coopersmith, Craig M.; Moreno, Maria Camargo; Hulsebus, Holly J.; Meena, Avtar S.; Souza‐Smith, Flavia M.; Roper, Philip M.; Foster, Michelle T.; Raju, S. Vamsee; Marshall, S. Alex; Fujita, Mayumi; Curtis, Brenda J.; Wyatt, Todd A.; Mandrekar, Pranoti; Kovacs, Elizabeth J.; Choudhry, Mashkoor A.

doi:10.1016/j.alcohol.2018.08.010

Cited by 6 publications

(4 citation statements)

References 70 publications

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“…In turn, whereas alcohol is a well-known pro-oxidant agent [77], the modulation of inflammatory and oxidative biomarkers largely depends on the type of beverage consumed [76,78,79], and part of these effects may be mediated by non-alcoholic components of alcoholic beverages as is further discussed. Again, heavy drinking increases the concentration of inflammatory and oxidative parameters [80][81][82] leading to CV morbidity.…”

Section: Intermediate Biomarkers Of Cardiovascular Diseasementioning

confidence: 99%

Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies

2019

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Alcohol has a hormetic physiological behavior that results in either increased or decreased cardiovascular risk depending on the amount consumed, drinking frequency, pattern of consumption, and the outcomes under study or even the type of alcoholic beverage consumed. However, the vast majority of studies elucidating the role of alcohol in cardiovascular and in the global burden of disease relies on epidemiological studies of associative nature which carry several limitations. This is why the cardiovascular benefits of low–moderate alcohol consumption are being questioned and perhaps might have been overestimated. Thus, the aim of this review was to critically discuss the current knowledge on the relationship between alcohol intake and cardiovascular disease. Besides new evidence associating low and moderate alcohol consumption with decreased risk of cardiovascular disease, several questions remain unanswered related to the concrete amount of safe consumption, the type of alcoholic beverage, and the age-, sex-, and genetic/ethnical-specific differences in alcohol consumption.

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Section: Intermediate Biomarkers Of Cardiovascular Diseasementioning

confidence: 99%

Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies

2019

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“…Omega-3 and omega-6 fatty acids are known for their modulating effects on inflammatory processes (27) and a dietary intake low in omega-6:omega-3-ratio of ideally ≤2:1 is associated with a reduced proinflammatory cytokine release (28). Furthermore, smoking (29), alcohol consumption (30), and medication use (31) can affect the inflammatory status. However, the number of smokers was low and alcohol intake between groups was comparable (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults

Haß

Kochlik

Weber

et al. 2022

The Journal of nutrition, health and aging

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Importance Inflammaging is considered a driver of age-related loss of muscle mass and function (sarcopenia). As nutrition might play a role in this process, the Dietary Inflammatory Index® (DII) has been developed to quantify the inflammatory potential of an individual diet. Objectives We aimed to examine associations between the DII, inflammation, oxidative stress and sarcopenia-related parameters in healthy old compared to young adults. Design, Setting, and Participants This cross-sectional study included data of 79 community-dwelling, healthy old adults (65–85 years) and 59 young adults (18–35 years) who participated in a randomized controlled trial from April to December 2019. Measurements The DII was computed with dietary data collected from 24-h recall interviews. Associations between the DII, inflammatory and oxidative stress markers as well as bioimpedance-derived body composition, handgrip strength and gait speed were determined with multiple linear regression analyses adjusted for age, sex, physical activity and insulin resistance. Results Regression analyses revealed significant relationships between a higher interleukin (IL) 6 and IL-6:IL-10-ratio and higher percentage fat mass (%FM), waist-to-height-ratio (WHtR) as well as lower percentage skeletal muscle mass (%SMM) and gait speed exclusively in old adults. Subsequent analyses showed that IL-6 was associated with a pro-inflammatory diet as indicated by a higher DII, again exclusively in old adults (beta coefficient (β)= 0.027, standard error (SE) 0.013, p=0.037). While the DII was not related with handgrip strength or oxidative stress in neither old nor young adults, linear models confirmed that a higher DII was inversely associated with gait speed in old participants (β= −0.022, SE 0.006, p<0.001). Finally, a pro-inflammatory diet was significantly associated with higher %FM, WHtR and lower %SMM in both age groups. Conclusion and Relevance A pro-inflammatory diet reflected by the DII is associated with higher systemic inflammation, slower gait speed as well as lower muscle mass in old adults. Intervention studies are needed to examine whether anti-inflammatory dietary approaches can help to improve muscle mass and function and thus minimize the risk for sarcopenia in the long-term.

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“…Interestingly, chronic alcohol abuse has been correlated with high iron concentrations in the skin [54]. Studies in aldehyde dehydrogenase 2 gene knockout mice or humans with dysfunctional alcohol metabolism have also shown that alcohol can cause increased skin pigmentation, although the downstream mechanisms are unclear [55]. Alcohol disrupts the iron-induced increase in hepatic hepcidin transcription, thereby impeding intestinal iron absorption and the release of iron from macrophages.…”

Section: Diets and Lifestyle On Ironmentioning

confidence: 99%

Examining How Diet and Lifestyle Influence Skin Appearance Through a Common Risk Factor: Excess Iron—A Comprehensive Review

Yang,

Chen,

Huang

2024

Preprint

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In the contemporary era, youthful and healthy skin is a pivotal determinant of beauty. Choices pertaining to one's dietary and lifestyle practices wield substantial influence over skin health. Currently, the focal point of attention lies in strategies to delay skin aging and maintain skin quality. Remarkably, the skin, the body's largest organ, serves as the primary defense barrier against external elements. Skin aging encompasses intrinsic and extrinsic categories, both susceptible to genetic, lifestyle, and environmental factors. Given the strides in science and technology, the pursuit of effective and safe interventions for skin aging assumes paramount importance. Thus, this review delves into the intricate relationship between diet, lifestyle, and skin aging, culminating in an exploration of the crucial role played by excess iron in this intricate nexus. Understanding these dynamics holds promise for advancing our knowledge of skincare and the quest for timeless vitality.

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Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting

Abstract: On November 21, 2014 the 19th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at Loyola University Chicago Health Sciences Campus in Maywood, Illinois. The meeting focused broadly on inflammatory cell signaling responses in the context of

Cited by 6 publications

References 70 publications

Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies

Benefits and Risks of Moderate Alcohol Consumption on Cardiovascular Disease: Current Findings and Controversies

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults

Examining How Diet and Lifestyle Influence Skin Appearance Through a Common Risk Factor: Excess Iron—A Comprehensive Review

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