In the framework of quantum chromodynamics (QCD), parton distribution functions (PDFs) quantify how the momentum and spin of a hadron are divided among its quark and gluon constituents. Two main approaches exist to determine PDFs. The first approach, based on QCD factorization theorems, realizes a QCD analysis of a suitable set of hard-scattering measurements, often using a variety of hadronic observables. The second approach, based on first-principle operator definitions of PDFs, uses lattice QCD to compute directly some PDF-related quantities, such as their moments. Motivated by recent progress in both approaches, in this document we present an overview of lattice-QCD and globalanalysis techniques used to determine unpolarized and polarized proton PDFs and their moments. We provide benchmark numbers to validate present and future lattice-QCD calculations and we illustrate how they could be used to reduce the PDF uncertainties in current unpolarized and polarized global analyses. This document represents a first step towards establishing a common language between the two communities, to foster dialogue and to further improve our knowledge of PDFs.The detailed understanding of the inner structure of nucleons is an active research field with phenomenological implications in high-energy, hadron, nuclear and astroparticle physics. Within quantum chromodynamics (QCD), information on this structure -specifically on how the nucleon's momentum and spin are divided among quarks and gluons -is encoded in parton distribution functions (PDFs).There exist two main methods to determine PDFs. 1 The first method is the global QCD analysis [3][4][5][6][7][8][9][10][11][12]. It is based on QCD factorization of physical observables, i.e. the fact that a class of hard-scattering cross-sections can be expressed as a convolution between short-distance, perturbative, matrix elements and long-distance, nonperturbative, PDFs. By combining a variety of available hard-scattering experimental data with state-of-the-art perturbative calculations, complete PDF sets, including the gluon and various combinations of quark flavors, are currently determined for protons, in both the unpolarized [13][14][15][16][17] and the polarized [18][19][20][21] case.Recent progress in global QCD analyses has been driven, on the one hand, by the increasing availability of a wealth of high-precision measurements from Jefferson Lab, HERA, RHIC, the Tevatron and the LHC and, on the other hand, by the advancement in perturbative calculations of QCD and electroweak (EW) higher-order corrections. Parton distributions are now determined with unprecedented precision, in many cases at the few-percent level. A paradigmatic illustration of this progress is provided by both the unpolarized and polarized gluon PDFs, which were affected by rather large uncertainties until recently, due to the limited experimental information available. In the unpolarized case, the gluon PDF is now constrained quite accurately from small to large x thanks to the inclusion of processes such a...