2009
DOI: 10.1073/pnas.0811088106
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Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling

Abstract: SUMO (small ubiquitin-related modifier) conjugation (i.e., sumoylation) to protein substrates is a reversible posttranslational modification that regulates signaling by modulating transcription factor activity. This paper presents evidence that the SUMO E3 ligase SIZ1 negatively regulates abscisic acid (ABA) signaling, which is dependent on the bZIP transcription factor ABI5. Loss-of-function T-DNA insertion siz1-2 and siz1-3 mutations caused ABA hypersensitivity for seed germination arrest and seedling primar… Show more

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Cited by 333 publications
(340 citation statements)
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“…After identifying the four novel genes with guard cell functions, we found that one of them, At5g60410 (SIZ1), is also associated with several root cell types by our method. This result is consistent with the observation that siz1 mutants are hypersensitive to ABA inhibition of root elongation (Miura et al, 2009). We also found that the kurtosis of SIZ1 is lower than that of other genes in our qRT-PCR analyses (Figure 5), consistent with known pleiotropic effects of siz1 (Miura et al, 2009).…”
Section: In Silico and Experimental Analysis Of Genes Shared Betweensupporting
confidence: 92%
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“…After identifying the four novel genes with guard cell functions, we found that one of them, At5g60410 (SIZ1), is also associated with several root cell types by our method. This result is consistent with the observation that siz1 mutants are hypersensitive to ABA inhibition of root elongation (Miura et al, 2009). We also found that the kurtosis of SIZ1 is lower than that of other genes in our qRT-PCR analyses (Figure 5), consistent with known pleiotropic effects of siz1 (Miura et al, 2009).…”
Section: In Silico and Experimental Analysis Of Genes Shared Betweensupporting
confidence: 92%
“…This result is consistent with the observation that siz1 mutants are hypersensitive to ABA inhibition of root elongation (Miura et al, 2009). We also found that the kurtosis of SIZ1 is lower than that of other genes in our qRT-PCR analyses (Figure 5), consistent with known pleiotropic effects of siz1 (Miura et al, 2009). Among the mutants we characterized experimentally, At1g11100 is also associated with both guard cells and root cells in our guard cell subnetwork (Figure 7), leading us to hypothesize that At1g11100 would also have a root-related function.…”
Section: In Silico and Experimental Analysis Of Genes Shared Betweensupporting
confidence: 92%
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“…In addition, MYB30 is reported to be involved in seed germination under ABA signaling [17]. Moreover, MYB30 protein levels are stabilized by a SUMO E3 ligase, SIZ1, and this stabilization is important in regulating the expression of certain ABA response genes [18]. According to these previous findings and our results, MYB30 might function as a root growth regulator under ABA signaling and stress responses.…”
Section: Interaction Between Myb30 and Plant Hormones In Root Growthsupporting
confidence: 74%
“…24 Other factors, such as ABI five binding protein (AFP), phosphorylation and sumoylation of ABI5 may also play a role in KEG-mediated ABI5 degradation, however the mechanism involved is still unclear. 30,34,35 Several other RING-type E3 ligases have been shown to function during ABA signaling. However, substrates for these E3 ligases remain to be identified.…”
Section: E3 Ligases and Aba Signalingmentioning
confidence: 99%