“…MES-4 instead deposits the activating mark H3K36me3 on germline expressed autosomal genes and antagonizes H3K27me3, leading to its concentration on the X (Gaydos et al, 2014; Bender et al, 2006). MRG-1, a component of several chromatin complexes in addition to SIN3S (Chen et al, 2010; Huang et al, 2017; Smith et al, 2013; Yochum and Ayer, 2002; Baytek et al, 2022), also contributes to silencing of the X in the C. elegans germline (Takasaki et al, 2007). Comparison of our list of sin-3(syb2172 ) upregulated genes on the X with a list of MES-3 and MRG-1 targets on the X (Cockrum and Strome, 2022) revealed commonly upregulated genes in the three mutants (37), as well as a larger set genes uniquely in common between mes-3 and mrg-1, as previously described ( Figure 4B) (Cockrum and Strome, 2022).…”