Sun Protection Factor Activity of Jamblang Leaves Serum Extract (Syzygium cumini)

Hidayah, Himyatul; Amal, Surya; Yuniarsih, Nia; F, Farhamzah Farhamzah; Kusumawati, Anggun Hari; Gunarti, Neni Sri; Abriyani, Ermi; Mursal, Iin Lidia Putama; Sundara, Adinda Khansa; Alkandahri, Maulana Yusuf

doi:10.5530/pj.2023.15.18

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…One requirement of a topical preparation is the pH value, where a too-acidic and basic pH value can cause skin irritation and scaling, with a pH of 4.5–6.5 [ 30 , 31 ]. Based on the pH measurement results of all HESt formulations, the average value for F0, F1, F2, and F3 was 5.09, 4.82, 4.76, and 4.69, respectively.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae)

Yuniarsih,

Hidayah,

Gunarti

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

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For centuries, communities have used medicinal plants to treat various diseases, such as Sansevieria trifasciata (Asparagaceae), for wound healing. However, a study on the wound-healing activity of this plant has not been conducted. Therefore, this study aimed to evaluate the hydrogel formulations of S. trifasciata extract (HESt) and its activity in wound healing. The HESt formulations were subjected to physical examination, pH measurement, spreading coefficient, rheological study, stability test, and wound-healing activity. Furthermore, the HPMC and carbopol 940 gel-forming agents were used to obtain this formulation. In the incision wound model, the experiment was divided into 5 groups, each consisting of 4 mice. Groups 1 and 2 served as a negative and positive control (octenidine gel), while 3, 4, and 5 were given HESt formulations of 15%, 20%, and 25% (w/w), respectively, for 15 days. Based on the wound healing activity test, HESt 20% and 25% (w/w) groups showed significant ( p < 0.05) wound closure area on day 4 and from day 2 to 16. However, the HESt 15% (w/w) group showed no significant difference in wound-healing activity but had a higher closure than the negative control. Based on the evaluation of the hydrogel, all HESt formulations were reported to have fulfilled the standard requirements. The HESt formulations were also reported to be stable at various temperatures in the stability test. Therefore, S. trifasciata leaves extract has the potential to be developed as a wound-healing drug derived from herbal plants formulated into hydrogel preparations.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae)

Yuniarsih,

Hidayah,

Gunarti

et al. 2023

Advances in Pharmacological and Pharmaceutical Sciences

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“…Syzygium cumini, popularly known as "amora-preta" or "jambolão", stands out for its applications in traditional folk medicine, indicating its pharmaceutical potential [16,19]. Several pharmacological activities are attributed to S. cumini, including antioxidant, antidiabetic, antidiarrheal, antiparasitic, and anti-inflammatory properties [32]. Antimicrobial activity has been reported in the essential oil of S. cumini leaves, tested against clinically relevant bacterial strains such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Silva,

Moreira,

Bezerra

et al. 2024

Future Pharmacology

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As microbes develop resistance to various drugs, the treatment of infections becomes increasingly challenging, leading to prolonged illness, heightened severity of infections, elevated mortality rates, and increased healthcare costs. Essential oils are lipophilic and volatile mixtures of compounds that have gained attention in research for novel antimicrobial agents. Therefore, the present study evaluated the essential oil of Syzygium cumini leaves (EOSC) in order to prospect its antifungal and trichomonacidal activities. The essential oil from the leaves was extracted by steam distillation and analyzed by GC-MS. Antifungal activity was evaluated using the serial microdilution method. Additionally, the potential of the EOSC as an enhancer of fluconazole (FCZ) action was tested at subinhibitory concentrations. To assess anti-Trichomonas vaginalis activity, concentrations ranging from 15.6 to 500 μg/mL of EOSC were tested. Finally, the SwissADME platform was employed to analyze the physicochemical and pharmacokinetic characteristics of the major component of EOSC. The GC-MS analysis identified 94.24% of the components of EOSC, with α-pinene (51.11%) and nerol (8.25%) as major constituents. EOSC exhibited low antifungal activity against the evaluated Candida strains. However, the combination of EOSC and FCZ reduced the IC50 against Candida krusei from 45.29 to 0.30 μg/mL. EOSC also demonstrated significant activity against T. vaginalis (IC50 = 88.2 μg/mL). In silico prediction with α-pinene showed low toxic action and important physicochemical aspects for drug production. The essential oil of Syzygium cumini emerges as a promising candidate for the discovery of molecules with potential antifungal and anti-Trichomonas vaginalis applications.

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“…About 5.0 kg of C. costata powder was macerated using 70% ethanol 3 times, 24 h each. The liquid extract was then collected and concentrated using a rotary evaporator (Eyela OSB-2100) at 50 °C ( 14 ). Subsequently, 100 g of dried C. costata extract was dissolved in a mixture of ethanol-water (1:3) and then fractionated using the liquid-liquid partition method with n -hexane (4 × 150 mL) and ethyl acetate (4 × 150 mL) as solvents.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological evaluation of anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Castanopsis costata leaf fractions (water, ethyl acetate, and n-hexane fractions): the potential medicinal plants from North Sumatra, Indonesia

Alkandahri,

Sadino,

Pamungkas

et al. 2024

Research in Pharmaceutical Sciences

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Background and purpose: Inflammation, fever, and pain can be associated with several diseases, and the synthetic drugs used in the treatment of these conditions often have severe side effects. As a result, there is a need for effective, economical, and safe alternative drugs, such as those derived from medicinal plants. Therefore, this study aimed to evaluate the anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Castanopsis costata leaf fractions (CcLF), as well as its acute toxicity. Experimental approach: For anti-inflammatory, antipyretic, and analgesic tests, rats were given CcLF (WFCC, EAFcC, and n-HFCC) at 50 and 100 mg/kg, diclofenac sodium (10 mg/kg), paracetamol (150 mg/kg), aspirin (100 mg/kg), and tramadol (20 mg/kg). For the antioxidant activity test, various concentrations of CcLF were used ranging from 25 to 200 μg/mL. This study also looked into whether there could be any acute toxicity and histopathology of the liver, stomach, and kidneys in experimental animals. Findings/Results: The administration of CcLF significantly inhibited the increase in foot edema volume, and CcLF (EAFCC at 100 mg/kg) considerably decreased rectal temperature and was proportional to the standard drug paracetamol, and significantly inhibited pain sensation in various models. Additionally, CcLF showed strong antioxidant activity, and its administration at a dose limit of 5000 mg/kg/day did not show any toxic effects or death in test animals. Conclusions and implications: The results of the current confirmed that CcLF has demonstrated anti-inflammatory, antipyretic, analgesic, and antioxidant properties in experimental models, and is practically non-toxic.

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Sun Protection Factor Activity of Jamblang Leaves Serum Extract (Syzygium cumini)

Abstract: Phytochemical screeningS. cumini extract was screened qualitatively to identify the presence of secondary metabolites, such as alkaloids, flavonoids, tannins, saponins, polyphenols, and steroids/triterpenoids. 10

Cited by 5 publications

References 14 publications

Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae)

Evaluation of Wound-Healing Activity of Hydrogel Extract of Sansevieria trifasciata Leaves (Asparagaceae)

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Pharmacological evaluation of anti-inflammatory, antipyretic, analgesic, and antioxidant activities of Castanopsis costata leaf fractions (water, ethyl acetate, and n-hexane fractions): the potential medicinal plants from North Sumatra, Indonesia

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