2020
DOI: 10.1111/exd.14230
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Sunitinib decreases the expression of KRT6A and SERPINB1 in 3D human epidermal models

Abstract: Small-molecule tyrosine kinase inhibitors (TKIs) of angiogenic signals are integral to current cancer chemotherapy. Considerable evidence supports the efficacy of angiogenic inhibitors against various types of cancer. 1,2 However, anti-angiogenic therapy produces characteristic side effects. Hand-foot skin reaction (HFSR) is a common side effect of several TKIs. HSFR causes hyperkeratosis on the palm or sole, causing pain and resulting in functional problems such as difficulty in walking and grasping. The qual… Show more

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Cited by 6 publications
(5 citation statements)
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“…In addition, downstream transcription activators AP1 and SP1 of ERK1/2 activate the expression of KRT19 in hepatoma cells [33]. Sunitinib reduced the expression of KRT6A by suppressing ERK1/2 and p38 MAPK signal transduction pathways in a skin model [34]. KRT80 promotes tumor progression by activating the AKT signaling pathway.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, downstream transcription activators AP1 and SP1 of ERK1/2 activate the expression of KRT19 in hepatoma cells [33]. Sunitinib reduced the expression of KRT6A by suppressing ERK1/2 and p38 MAPK signal transduction pathways in a skin model [34]. KRT80 promotes tumor progression by activating the AKT signaling pathway.…”
Section: Discussionmentioning
confidence: 99%
“…Candidate drugs, clofazimine, cyclosporin A, and itraconazole, significantly increased the number of PCNA-positive cells in the presence of sorafenib ( Figure7e– g and j). Meanwhile, it has been reported that sunitinib treatment significantly decreased the expression of KRT6A in immunohistochemical staining of RHE model ( Yoshida et al, 2021 ). However, sorafenib did not change KRT6A expression in RHE model ( Figure 22 a–c).…”
Section: Discussionmentioning
confidence: 99%
“…We followed the methodology of a previous report [ 29 ]. After rinsing with ice-cold phosphate-buffered saline (PBS), the cells were treated with ice-cold lysis buffer (containing 20 mM HEPES, 120 mM NaCl, 5 mM EDTA, 1% Triton X-100, 10% glycerol, 10 mM dithiothreitol, 0.5 mM Phenylmethylsulfonyl fluoride, 1 mM sodium fluoride, and 5 µg/mL leupeptin), and the concentrations of protein were measured by using the Bradford assay.…”
Section: Methodsmentioning
confidence: 99%