Sunscreening agent intolerance: Contact and photocontact sensitization and contact urticaria

Dromgoole, Sydney H.; Maibach, Howard I.

doi:10.1016/0190-9622(90)70154-a

Cited by 129 publications

(53 citation statements)

References 73 publications

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“…Oxybenzone and isopropyl dibenzoylmethane were responsible for 6 out of 8 cases of sun screen contact dermatitis. This probably reflects the diffusive spreading of these chemicals due to their broad absorption spectrum [2,6,9]. Oxybenzone is undoubtedly the common est UV filter in cosmetics, and we detected allergy and/or photoallergy to this compound in 3.7% of our cases.…”

Section: Discussionmentioning

confidence: 77%

“…In all of them sensitization occurred after use of a sunscreen formulation. This compound is widespread in Europe where it has been employed since 1980 [6], while it is not incorporated in USA sunscreens [2], No positive reactions to butyl methoxydibenzoylmethane were found in spite of its increasing diffusion in Europe. This seems to confirm that Parsol 1789 could be a weaker sensitizer than the isopropyl derivative [2, 6|.…”

Section: Discussionmentioning

confidence: 99%

“…As a result some authors consider sun screens as weak sensitizers [1,2], Nater and de Groot [3] reported an incidence rate of side effects due to sunscreen ing agents from 1 to 2% with a low to medium risk index in the general population. However in the last few years sen sitization to these agents is increasing because of their extensive diffusion for esthetic and preventive reasons.…”

Section: Discussionmentioning

confidence: 99%

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Sunscreen Sensitization: A Three-Year Study

et al. 1994

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Background: In the last decade UV filters have been incorporated in a large number of cosmetic products. Objective: The purpose of our study was to evaluate the prevalence of sunscreen allergy in patients with a suspected photodermatitis. Methods: 108 patients were patch-tested with the Gruppo Italiano Ricerca Dermatiti da Contatto e Ambientali (GIRDCA) standard series and photopatch-tested with the photopatch series. Results: Allergy and/or photoallergy to sunscreening agents was diagnosed in 8 subjects (7.4%). Oxybenzone was positive in 4 patients, isoproyl dibenzoylmethane in 3 patients, p-aminobenzoic acid and 2-ethylhexyl-p-methoxycinnamate in 1 patient, respectively. Conclusion: Our results obtained during a 3-year period (January 1990 to June 1993) confirm that sunscreens are presently the commonest photoallergens.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Sunscreen Sensitization: A Three-Year Study

et al. 1994

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“…This will leads to loss of potency during storage or application (7), resulting in skin irritation and allergy (7,30). Vesicular formulations are known to provide the protection for photolabile drug.…”

Section: Photodegradation Studymentioning

confidence: 99%

Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent

2010

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Abstract. In the present study attempt was made for preparation of isotretinoin-hydroxypropyl β cyclodextrin (HP-β-CD) inclusion complex and encapsulate this complex in elastic liposomes to study the effect of dual carrier approach on skin targeting of isotretinoin. The isotretinoin HP-β-CD complex was prepared by freeze-drying method and characterized by IR spectroscopy. The drug and drug-CD complex loaded elastic liposomal formulation were prepared and characterized in vitro, ex-vivo and in vivo for shape, size, entrapment efficiency, no. of vesicles per cubic mm, in vitro skin permeation and deposition study, photodegradation and skin toxicity assay. The transdermal flux for different vesicular formulations was observed between 10.5±0.5 to 13.9±1.6 μg/cm 2 /h. This is about 15-21 folds higher than that obtained from drug solution (0.7 ±0.1 μg/cm 2 /h) and 4-5 folds higher than obtained with drug-CD complex solution (2.7±0.1 μg/cm 2 /h). The amount of drug deposit was found to increase significantly (p<0.05) by cyclodextrin complexation (30.1±0.1 μg). The encapsulation of this complex in elastic liposomal formulation further increases its skin deposition (262.2 ±21 μg). The results of skin irritation study using Draize test also showed the significant reduction in skin irritation potential of isotretinoin elastic liposomal formulation in comparison to free drug. The results of the present study demonstrated that isotretinoin elastic liposomal formulation possesses great potential for skin targeting, prolonging drug release, reduction of photodegradation, reducing skin irritation and improving topical delivery of isotretinoin.

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“…Furthermore, it should be noted that the high incidence of dermatologic side effects observed for PABA (Chignell et al 1980;Sutherland and Griffin 1984;Dromgoole and Mailbach 1990;Aliwell et al 1993;Allen et al 1996;Mackie and Mackie 1999) was the reason why this sunscreen agent, widely used in the past, is not currently approved for use as a UV filter in cosmetic products in the European Union (Regulation (EC) No 1223/2009). Therefore, it becomes necessary to combine different scientific disciplines to further study the systemic effects that may be caused by possible metabolites of EDP.…”

Section: Aim Of the Studymentioning

confidence: 98%

Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products

González

2014

Springer Theses

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Sunscreening agent intolerance: Contact and photocontact sensitization and contact urticaria

Cited by 129 publications

References 73 publications

Sunscreen Sensitization: A Three-Year Study

Sunscreen Sensitization: A Three-Year Study

Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent

Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products

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