<sup>1</sup>H-MR-Spektroskopie bei Anorexia nervosa: Reversible zerebrale Metabolitenänderungen

Möckel, Regina; Gückel, F.; Göpel, Christopher; Becker, Guillaume; Köpke, Julian; Hentschel, Frank; Schmidt, Martin C.; Georgi, M

doi:10.1055/s-2007-1011056

Cited by 10 publications

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“…We found a higher Cho/Cr ratio in all brain regions of anorexics, except the precuneus, affecting both white and gray matter, which is in agreement with previous studies. 11 , 12 , 13 , 14 This possibly reflects increased cell turnover, and catabolism of lipid membranes with release of fatty acids from phospholipids. In reality, the peak of choline mainly represents glycerophosphocholine.…”

Section: Discussionmentioning

confidence: 99%

Metabolic changes in the cingulate gyrus, precuneus, and white matter in anorexia nervosa using multivoxel MR spectroscopy

Regnaud

Boto

Klauser

et al. 2021

Journal of Neuroimaging

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Background and Purpose: This study aimed to highlight anorexia nervosa-related metabolic changes in different brain regions with different gray and white matter contents. Methods:In a prospective study, 25 anorexic patients with mean body mass index (BMI) of 14.79 kg/m 2 (range 10.04-20.58) were compared with 15 healthy controls with mean BMI of 21.08 kg/m 2 (range 18.36-27.34). Two-dimensional magnetic resonance spectroscopic imaging was acquired in the axial plane above the corpus callosum, including frontal, precentral, postcentral, cingular, and parietal regions, as well as the precuneus, each voxel containing gray and white matter. Results:In the anorexic group, a significant increase of choline/creatine was observed in all brain regions except the precuneus: frontal (p = 0.009), cingulate (p = 0.001), precentral (p = 0.001), postcentral (p = 0.001), and parietal (p = 0.002); and in white and gray matter (p< 0.001). Macromolecules09/creatine was decreased in the following regions: frontal (p = 0.003), cingulate (p< 0.001), precentral (p = 0.004), and precuneus (p = 0.007), and in white and gray matter (p< 0.05). We observed significantly lower values of N-acetyl aspartate/creatine in the frontal (p < 0.001) and precentral (p< 0.001) regions and in voxels containing more than 50% white matter (p = 0.001); and significantly lower values of myo-inositol/creatine in the precentral (p = 0.006), postcentral (p< 0.001), and precuneus (p = 0.006) regions. Conclusions:We observed an increase in choline/creatine in anorexics, possibly reflecting increased cell turnover; a decrease in macromolecules, which was particularly low in the cingulate and precuneus the former being known to be altered in eating disorders; and a decrease in N-acetyl aspartate/creatine considered as a marker of neuronal density and function.

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Section: Discussionmentioning

confidence: 99%

Metabolic changes in the cingulate gyrus, precuneus, and white matter in anorexia nervosa using multivoxel MR spectroscopy

Regnaud

Boto

Klauser

et al. 2021

Journal of Neuroimaging

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“…Previous 1.5-T studies, employing 1 H single voxel spectroscopy (SVS), reported increased choline/creatine ratios (Cho/Cr) in the parietooccipital WM of young AN patients. The increase was reversible upon weight increase [43][44][45]. These findings were discussed as transitional alterations of phosphatidylcholine turnover.…”

Section: Introductionmentioning

confidence: 99%

Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

et al. 2012

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Significant changes in GM metabolite concentrations were observed in AN possibly triggered by elevated excitotoxin Glu. Increased tCho may indicate modifications of membrane phospholipids due to increased catabolism in the parietal region. Since no significant changes in phosphorylated choline compounds were found for the frontal region, the tCho increase in this region may hint to fluidity changes.

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A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

Kim

McGrath

Silverstone

2005

Human Psychopharmacology

119

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Myo-inositol is an important part of the phosphatidylinositol second messenger system (PI-cycle). Abnormalities in nerve cell myo-inositol levels and/or PI-cycle regulation has been suggested as being involved in the pathophysiology and/or treatment of many psychiatric disorders including bipolar disorder, major depressive disorder, panic disorder, obsessive-compulsive disorder, eating disorders and schizophrenia. This review examines the metabolism and biochemical importance of myo-inositol and the PI-cycle. It relates this to the current in vivo evidence for myo-inositol and PI-cycle involvement in these psychiatric disorders, particularly focusing upon the magnetic resonance spectroscopy (MRS) findings in patient studies to date. From this review it is concluded that while the evidence suggests probable relevance to the pathophysiology and/or treatment of bipolar disorder, there is much less support for a significant role for the PI-cycle or myo-inositol in any other psychiatric disorder. More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder.

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¹H-MR-Spektroskopie bei Anorexia nervosa: Reversible zerebrale Metabolitenänderungen

Abstract: 1H-MR spectroscopy reveals metabolic changes in the brain of patients with anorexia nervosa, which are reversible under successful therapy. These metabolic changes can be conclusively explained using a biochemical model.

Cited by 10 publications

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Metabolic changes in the cingulate gyrus, precuneus, and white matter in anorexia nervosa using multivoxel MR spectroscopy

Metabolic changes in the cingulate gyrus, precuneus, and white matter in anorexia nervosa using multivoxel MR spectroscopy

Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

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1H-MR-Spektroskopie bei Anorexia nervosa: Reversible zerebrale Metabolitenänderungen

Abstract: 1H-MR spectroscopy reveals metabolic changes in the brain of patients with anorexia nervosa, which are reversible under successful therapy. These metabolic changes can be conclusively explained using a biochemical model.

Cited by 10 publications

References 0 publications

Metabolic changes in the cingulate gyrus, precuneus, and white matter in anorexia nervosa using multivoxel MR spectroscopy

Metabolic changes in the cingulate gyrus, precuneus, and white matter in anorexia nervosa using multivoxel MR spectroscopy

Metabolic gray matter changes of adolescents with anorexia nervosa in combined MR proton and phosphorus spectroscopy

A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI‐cycle) to psychiatric disorders—focus on magnetic resonance spectroscopy (MRS) studies

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¹H-MR-Spektroskopie bei Anorexia nervosa: Reversible zerebrale Metabolitenänderungen