¹H,¹³C and ¹⁹F NMR data of N‐substituted 6‐(4‐methoxyphenyl)‐7H‐pyrrolo[2,3‐d]pyrimidin‐4‐amines in DMSO‐d₆

Abstract

Chemical shift assignment of seven N-substituted 6-(4-methoxyphenyl)-7H-pyrrolo[2, 3-d]pyrimidin-4-amines, six of which are fluorinated, have been performed based on (1)H, (13)C, (19)F, and 2D COSY, HMBC and HSQC experiments.

Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena

“…Diseases caused by parasitic protozoa, as for instance malaria, 38 dysentery, leishmaniasis, and human African trypanosomiasis are 39 major causes of mortality throughout the world, thus, the study 40 of effects of organic compounds on protozoa is important. Thera- 41 peutic agents are available [1,2] however, many of the drugs have 42 critical side effects [3,4] and also resistance is emerging [5,6].…”