<sup>13</sup>C NMR aided design of molecularly imprinted adsorbents for selectively preparative separation of erythromycin

Zhang, Yuxin; Qu, Xue; Yu, Jinpeng; Xu, Liancai; Zhang, Zhiqiang; Hong, Hao; Liu, Changsheng

doi:10.1039/c3tb21636e

Cited by 27 publications

(30 citation statements)

References 48 publications

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“…Investigations involving template–monomer complex studies have employed different methods, basis sets and levels of theories on several occasions. The majority of these studies employed DFT methods [ 124 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 ,…”

Section: The Pre-polymerization Stagementioning

confidence: 99%

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

et al. 2021

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Recent years have witnessed a dramatic increase in the use of theoretical and computational approaches in the study and development of molecular imprinting systems. These tools are being used to either improve understanding of the mechanisms underlying the function of molecular imprinting systems or for the design of new systems. Here, we present an overview of the literature describing the application of theoretical and computational techniques to the different stages of the molecular imprinting process (pre-polymerization mixture, polymerization process and ligand–molecularly imprinted polymer rebinding), along with an analysis of trends within and the current status of this aspect of the molecular imprinting field.

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Section: The Pre-polymerization Stagementioning

confidence: 99%

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

et al. 2021

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“…Andersson et al used this technique to optimize the template-functional monomer proportion. [104] Simple 13 C-NMR alone had not been used for the evaluation of the template-functional monomer interaction, until Zhang et al [105] reported a study where it was utilized to evaluate the interactions between antibiotic erythromycin (ERY) and a set of functional monomers, with the choice of MAA as the optimal one. The rational binding sites were predicted based on chemical shifts changes in ERY structure.…”

Section: Nmr Techniques Aiding Mip Productionmentioning

confidence: 99%

Approaches to the Rational Design of Molecularly Imprinted Polymers Developed for the Selective Extraction or Detection of Antibiotics in Environmental and Food Samples

Jamieson

Mecozzi

Crapnell

et al. 2021

Physica Status Solidi (a)

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The World Health Organisation (WHO) reported antimicrobial resistance (AMR) as a global threat comparable to terrorism and climate change. The use of antibiotics in veterinary or clinical practice exerts a selective pressure, which accelerates the emergence of antimicrobial resistance. Therefore, there is a clear need to detect antibiotic residues in complex matrices, such as water, food, and environmental samples, in a fast, selective, cost‐effective, and quantitative manner. Once problematic areas are identified, can extraction of the antibiotics then be carried out to reduce AMR development. Molecularly imprinted polymer (MIPs) are synthetic recognition elements produced through the biomarker of interest being used as a template in order to manufacture tailor‐made ligand selective polymeric recognition sites. They are emerging steadily as a viable alternative to antibiotics, especially given their low‐cost, superior thermal and chemical stability that facilitates on‐site detection, simplified manufacturing process, and avoiding the use of animals in the production process. In this paper, the authors critically review literature from primarily 2010–2020 on rational design approaches used to develop MIPs for sensing and extraction of antibiotics, providing an outlook on crucial issues that need to be tackled to bring MIPs for antibiotic sensing to the market.

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“…Since the idea of molecular imprinting was first put forward by Pauling in 1940s [43], over the past decades, it is well known that molecular imprinting is a very promising and rapidly evolving technology, with many possible applications such as preparative analytical separations [44][45], enzyme-like catalysis [46][47], solidphase extractions [48][49], chemical sensors [50][51] and drug delivery [52][53], etc. Molecular imprinting has proven to be particularly successful for small molecules.…”

Section: Photonic Crystalsmentioning

confidence: 99%

Molecular imprinted photonic crystal for sensing of biomolecules

Chen¹,

Meng²,

Xue³

et al. 2016

Molecular Imprinting

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Molecularly imprinted polymers (MIPs) are highly cross-linked polymers with high binding capacity and selectivity to the target molecules. MIPs become increasingly important because of the potential applications in drug delivery, purification and separation. In spite of the tremendous progress that has been made in the molecular imprinting field, many challenges remain to be addressed, especially in transforming the binding event into a detectable optical signal. The combination of photonic crystal and molecular imprinting technique is becoming a popular research idea. Compared to the conventional MIPs, the molecularly imprinted photonic crystal sensors (MIPCB) have the advantage of directly convert the molecule recognition process into optical signal. This review comprehensively summarizes various MIPCB, including the principle of molecular imprinted photonic crystal sensors, recent development, some challenges and effective strategies for MIPCB.

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¹³C NMR aided design of molecularly imprinted adsorbents for selectively preparative separation of erythromycin

Abstract: Based on the 13C chemical shift changes, the optimal monomer of MAA was selected and the rational binding sites were predicted. The resultant materials show good selectivity for erythromycin.

Cited by 27 publications

References 48 publications

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

Approaches to the Rational Design of Molecularly Imprinted Polymers Developed for the Selective Extraction or Detection of Antibiotics in Environmental and Food Samples

Molecular imprinted photonic crystal for sensing of biomolecules

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13C NMR aided design of molecularly imprinted adsorbents for selectively preparative separation of erythromycin

Abstract: Based on the 13C chemical shift changes, the optimal monomer of MAA was selected and the rational binding sites were predicted. The resultant materials show good selectivity for erythromycin.

Cited by 27 publications

References 48 publications

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers

Approaches to the Rational Design of Molecularly Imprinted Polymers Developed for the Selective Extraction or Detection of Antibiotics in Environmental and Food Samples

Molecular imprinted photonic crystal for sensing of biomolecules

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Product

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¹³C NMR aided design of molecularly imprinted adsorbents for selectively preparative separation of erythromycin