<sup>13</sup>C‐urea Breath Test during Hospitalization for the Diagnosis of <i>Helicobacter pylori</i> Infection in Peptic Ulcer Bleeding

Gisbert, Javier P.; Esteban, Carlos; Jiménez, Isabel; Moreno–Otero, Ricardo

doi:10.1111/j.1523-5378.2007.00492.x

Cited by 28 publications

(18 citation statements)

References 56 publications

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“…That was consistent with many guidelines as infection of H pylori can be diagnosed by endoscopic biopsy of the gastric mucosa or by non-invasive methods like Urea Breath Test (UBT) [11,26,27].…”

Section: Discussionsupporting

confidence: 86%

Evaluation of Helicobacter pylori Eradication Therapy in Dyspeptic Patients in a Teaching Hospital

Abusham¹,

Mohammed²

2016

Int J Clin Pharmacol Pharmacother

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Objectives: The main purpose of this study was to evaluate H pylori eradication therapy in a tertiary care teaching hospital. Method: In this retrospective study, the eradication therapy for 83 patients was evaluated. Data was collected over six-month period. All prescriptions identified as for H pylori eradication during that period were considered eligible for the study. Patients' medical records were also reviewed. Collection of data was done using a predesigned data collection form. Analysis was performed using Statistical Package (STATA v12.0). Results: Regimens considered inappropriate comprised 41% of all prescribed regimens. Eighty percent of the inappropriate regimens consist of one or no antibiotic. "H pylori associated chronic gastritis" represents 88% of indications for eradication therapy. Abdominal pain and headache appeared to be the most commonly encountered adverse drug reactions (ADRs) in patients prescribed eradication therapy. Seventy six percent of the interviewed patients reported that they were not counseled about the potential ADRs of the prescribed medications. Conclusion: A number of inappropriate therapies for eradication of H pylori were observed. Patients were not fully aware of potential adverse drug reactions, which compromise patient compliance. Prescribing for H pylori eradication could be improved through well-defined guidelines. Patients should be counselled on the negative consequences of poor adherence to eradication therapy.

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Section: Discussionsupporting

confidence: 86%

Evaluation of Helicobacter pylori Eradication Therapy in Dyspeptic Patients in a Teaching Hospital

Abusham¹,

Mohammed²

2016

Int J Clin Pharmacol Pharmacother

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“…Application of these tests for gold standard might pose a bias to the result. Therefore, we chose a single 13 C-UBT as the gold standard for Hp infection in our study because it is still accurate in patients with peptic ulcer bleeding [8,22], especially performed at earlier time after the bleeding episode [23].…”

Section: Discussionmentioning

confidence: 99%

Increasing Biopsy Number and Sampling from Gastric Body Improve the Sensitivity of Rapid Urease Test in Patients with Peptic Ulcer Bleeding

et al. 2014

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“…The sensitivity of this study is not affected by blood in the stomach and is higher than those of biopsybased methods and other noninvasive tests [ 37 ]. Nonetheless, since patients should drink a ureacontaining solution with a test meal or citric acid, this method is not suitable for bleeding patients.…”

Section: Urea Breath Testmentioning

confidence: 79%

Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding

Choi

2016

Helicobacter Pylori

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The main causes for upper gastrointestinal (GI) bleeding are peptic ulcer disease such as benign gastric ulcer (BGU) or duodenal ulcer (DU). Helicobacter pylori ( H. pylori ) infection was detected up to 70 % in patients with BGU and 90 % in patients with DU. Since many studies demonstrated the benefi t of H. pylori eradication in decreasing peptic ulcer recurrences, as well as in bleeding cases, it is very important to diagnose the infection accurately among those with peptic ulcer diseases. There are several tests for detection of H. pylori with variable levels of sensitivity and specifi city, and upper GI bleeding would reduce sensitivity. In case of upper GI bleeding, 13 C-UBT urea breath test is more sensitive than tests with biopsied mucosa such as rapid urease test, histological test or culture study. Keywords Bleeding • Helicobacter pylori • Rapid urease test • Urea breath test IntroductionUpper gastrointestinal (UGI) bleeding is the most serious complications of peptic ulcer diseases, which can lead to the mortality. The well-known risk factors for peptic ulcer diseases are Helicobacter pylori ( H. pylori ) infection and the administration of non-steroidal anti-infl ammatory drug (NSAID). When the subjects with UGI bleeding or NSAID users were excluded, H. pylori infection was detected up to 70 % in patients with benign gastric ulcer (BGU) and 90 % in patients with duodenal ulcer (DU) [ 1 ]. Since H. pylori infection is a single predictive factor for re-bleeding in patients with DU [ 2 ] and eradication of the organism can reduce the risk of re-bleeding signifi cantly [ 3 , 4 ], international guideline has recommended the tests for diagnosis of H. pylori infection in case of upper GI bleeding with peptic ulcer disease [ 5 ].

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¹³C‐urea Breath Test during Hospitalization for the Diagnosis of Helicobacter pylori Infection in Peptic Ulcer Bleeding

Cited by 28 publications

References 56 publications

Evaluation of Helicobacter pylori Eradication Therapy in Dyspeptic Patients in a Teaching Hospital

Evaluation of Helicobacter pylori Eradication Therapy in Dyspeptic Patients in a Teaching Hospital

Increasing Biopsy Number and Sampling from Gastric Body Improve the Sensitivity of Rapid Urease Test in Patients with Peptic Ulcer Bleeding

Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding

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13C‐urea Breath Test during Hospitalization for the Diagnosis of Helicobacter pylori Infection in Peptic Ulcer Bleeding

Cited by 28 publications

References 56 publications

Evaluation of Helicobacter pylori Eradication Therapy in Dyspeptic Patients in a Teaching Hospital

Evaluation of Helicobacter pylori Eradication Therapy in Dyspeptic Patients in a Teaching Hospital

Increasing Biopsy Number and Sampling from Gastric Body Improve the Sensitivity of Rapid Urease Test in Patients with Peptic Ulcer Bleeding

Specific Conditions: Diagnosis of H. pylori Infection in Case of Upper Gastrointestinal Bleeding

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¹³C‐urea Breath Test during Hospitalization for the Diagnosis of Helicobacter pylori Infection in Peptic Ulcer Bleeding