[<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography–Positive Gastric Adenocarcinoma in a 12-Year-Old Girl With Peutz-Jeghers Syndrome

Schneider, C; Simon, Thorsten; Hero, Barbara; Uphoff, U. Schulze; Drebber, Uta; Alakus, Hakan; Holinski‐Feder, Elke; Berthold, Frank; Dietlein, Markus; Schmidt, Matthias

doi:10.1200/jco.2011.39.7422

Cited by 4 publications

(2 citation statements)

References 23 publications

(17 reference statements)

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“…Peutz-Jeghers syndrome is a rare inherited autosomal dominant syndrome characterized by mucocutaneous pigmentations and diffuse gastrointestinal hamartomatous polyps. 2,3 Although hamartomatous polyps are generally assumed to have a low malignant potential, malignant transformation within the polyps has been observed in patients with Peutz-Jeghers syndrome. 4 It may be difficult to discriminate gastrointestinal polyps or adenomas from cancer on FDG PET because both can show increased FDG uptake.…”

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“…Clear cell sarcoma was confirmed by pathology. Peutz-Jeghers syndrome is a rare inherited autosomal dominant syndrome characterized by mucocutaneous pigmentations and diffuse gastrointestinal hamartomatous polyps 2,3. Although hamartomatous polyps are generally assumed to have a low malignant potential, malignant transformation within the polyps has been observed in patients with Peutz-Jeghers syndrome 4.…”

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confidence: 99%

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68Ga-FAPI-04 Versus 18F-FDG PET/CT in a Case of Peutz-Jeghers Syndrome

Dong

Zhang²,

Zhang³

et al. 2022

Clin Nucl Med

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Peutz-Jeghers syndrome is a rare inherited hamartomatous polyposis syndrome. We describe 68 Ga-FAPI-04 and 18 F-FDG PET/CT findings in a case of Peutz-Jeghers syndrome with primary duodenal clear cell sarcoma, peritoneal metastases, and multiple intestinal polyps varying in size. The duodenal tumor and its metastases showed increased FDG and FAPI uptake. The peritoneal metastases were delineated more clearly on FAPI PET/CT compared with FDG PET/CT. More interestingly, the intestinal polyps showed increased FDG uptake and no FAPI uptake.

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confidence: 99%