<sup>31</sup>P magnetic resonance spectroscopy of traumatic spinal cord injury

Vink, Robert; Knoblach, Susan M.; Faden, Alan I.

doi:10.1002/mrm.1910050413

Cited by 23 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phospholipase C activity has also been found to increase after experimental concussive head injury (Wei et al, 1982). Following spinal cord trauma, energy stores are rapidly depleted, with ATP levels falling to less than 20% of normal values (Walker et al, 1977;Anderson et al, 1980;Vink et al, 1987). This would be expected greatly to diminish the rates of FFA reacylation and de novo phospholipid synthesis, which require ATP and other high-energy intermediates (Dawson, 1973;Sun et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord

Demediuk

Daly

1989

J of Neuroscience Research

View full text Add to dashboard Cite

Free fatty acids (FFA), phospholipid, and cholesterol levels were measured in spinal cord samples from rats subjected to low (25 g-cm), moderate (50 g-cm), or severe (100 g-cm) impact trauma to the T10 spinal segment. All degrees of injury caused early (15 min) declines in total phospholipids after trauma; phospholipid levels remained significantly below controls in rats subjected to moderate and severe injuries for up to 3 days, whereas phospholipids had returned to baseline values by 4 hr in the low injury group. Rapid and persistent decreases in cholesterol levels were observed for all injury groups. Severe trauma was associated with biphasic increases in FFA levels: levels were elevated at 5 and 15 min post-trauma and had declined by 30 min; a second elevation was observed at 1 hr, progressively increasing to reach a maximum at 24 hr, before declining over the next 6 days. Low and moderate injuries caused similar early total FFA increases; later increases were significantly smaller than in the severely injured group. Among the free fatty acids, significant increases were observed in palmitate, stearate, oleate, linoleate, linolenate, arachidonate, and docosahexaenoate. These findings indicate that traumatic spinal cord injury results in early, transient, postinjury membrane phospholipid hydrolysis, the magnitude of which is relatively independent of the severity of injury. More delayed and sustained lipid hydrolysis also occurs after trauma, the magnitude of which is related to the severity of injury.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord

Demediuk

Daly

1989

J of Neuroscience Research

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6] This can be attributed largely to the relatively small size of the spinal cord and physiologic pulsation motion at some spinal level sites, which in turn limits our ability to acquire nuclear magnetic resonance (NMR) spectra with adequate signal-to-noise ratio. In particular, only one in vivo study has been reported using 31 P-NMR in animals.…”

mentioning

confidence: 99%

In Vivo Proton Magnetic Resonance Spectroscopy of Human Spinal Mass Lesions

Kim¹,

Choi²,

Kim³

et al. 2004

Journal of Spinal Disorders &Amp; Techniques

View full text Add to dashboard Cite

It appeared that acquisition of in vivo 1H-NMR signals was possible in human spinal mass lesions on a 1.5 T clinical MRI unit. Detection of choline only in the spinal tumors may indicate that there is some potential in using in vivo 1H-MRS to distinguish spinal tumors from disc herniation mimicking spinal cord tumors, non-multiple sclerosis myelitis, and dermoid cysts. On the basis of our NMR findings, however, it was not possible to distinguish between benign diseases.

show abstract

“…In vivo NMR shows great potential for the study of spinal cord morphology and biochemistry, but this application of NMR is limited by the relatively small size of the spinal cord, its deep anatomical locations, and low sensitivity of NMR measurements. The spinal cord has been studied with surface‐coil 1 H imaging (see for example 5 and 1 H and 31 P spectroscopy (6–11). In a recent study, Zelaya el al.…”

mentioning

confidence: 99%

In vivo ¹H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively‐coupled chronically implanted RF coil

Silver

Mercer

et al. 2001

Magnetic Resonance in Med

View full text Add to dashboard Cite

An inductively coupled, chronically implanted short-solenoid coil was used to obtain in vivo localized 1 H NMR spectra and diffusion-weighted images from a rat spinal cord. A 5 ؋ 8 mm two-turn elliptically shaped solenoid coil was implanted in rats at the site of a T-12 vertebral-level laminectomy. Excitation was achieved solely by a 3 ؋ 3 cm external surface coil, and signal detection was achieved by inductively coupling the external coil to the implanted coil. The image signal-to-noise ratio (SNR) obtained with the inductively-coupled implanted coil was compared with that obtained using a linear or a quadrature external surface coil. The implanted coil provided a gain by over a factor of 3 in SNR. The implanted coil was used to measure localized 1 H spectra in vivo at the T13/L1 spinal-cord level within a 1.85 ؋ 1.85 ؋ 4.82 mm (16.5 L) volume. With 256 averages, a ϳ3-s repetition delay and respiratory gating, a high-quality spectrum was acquired in 13 min. In addition, water translational diffusion was measured in three orthogonal directions using a stimulatedecho imaging sequence, with a short echo time (

show abstract

³¹P magnetic resonance spectroscopy of traumatic spinal cord injury

Cited by 23 publications

References 15 publications

Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord

Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord

In Vivo Proton Magnetic Resonance Spectroscopy of Human Spinal Mass Lesions

In vivo ¹H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively‐coupled chronically implanted RF coil

Contact Info

Product

Resources

About

31P magnetic resonance spectroscopy of traumatic spinal cord injury

Cited by 23 publications

References 15 publications

Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord

Changes in free fatty acids, phospholipids, and cholesterol following impact injury to the rat spinal cord

In Vivo Proton Magnetic Resonance Spectroscopy of Human Spinal Mass Lesions

In vivo 1H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively‐coupled chronically implanted RF coil

Contact Info

Product

Resources

About

³¹P magnetic resonance spectroscopy of traumatic spinal cord injury

In vivo ¹H magnetic resonance imaging and spectroscopy of the rat spinal cord using an inductively‐coupled chronically implanted RF coil