Supercritical CO2 foamed composite scaffolds incorporating bioactive lipids promote vascularized bone regeneration via Hif-1α upregulation and enhanced type H vessel formation

Li, Shuang; Song, Chaobo; Yang, Shengbing; Yu, Weijun; Zhang, Weiqi; Zhang, Guohua; Xi, Zhenhao; Lu, Eryi

doi:10.1016/j.actbio.2019.05.066

Cited by 58 publications

(64 citation statements)

References 76 publications

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“…CO 2 foamed composite scaffold incorporating bioactive lipids promotes vascularization and bone regeneration via HIF1‐α upregulation and enhanced type H vessel formation. ( 211 ) Mechanobiologically optimized magnesium (Mg) scaffolds (CaP‐coated Mg‐Zn‐Gd scaffolds) enhance the ratio of type H ECs and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) during repair of orbital bone defects. ( 212 ) Moreover, deferoxamine‐loaded 3D‐printed biodegradable scaffold fabricated via surface aminolysis and layer‐by‐layer assembly technique shows enhanced HIF1‐α, CD31 high expression ECs, and osteogenesis.…”

Section: Angiogenesis and Vascularization In Bone Tissue Engineeringmentioning

confidence: 99%

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

Chen

Hendriks

Chatzis

et al. 2020

Journal of Bone and Mineral Research

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Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete angiocrine factors required for the survival, maintenance, and self-renewal of stem and progenitor cells. In the skeletal system, vasculature creates nurturing niches for bone and blood-forming stem cells. Blood vessels regulate hematopoiesis and drive bone formation during development, repair, and regeneration. Dysfunctional vascular niches induce skeletal aging, bone diseases, and hematological disorders. Recent cellular and molecular characterization of the bone marrow microenvironment has provided unprecedented insights into the complexity, heterogeneity, and functions of the bone vasculature and vascular niches. The bone vasculature is composed of distinct vessel subtypes that differentially regulate osteogenesis, hematopoiesis, and disease conditions in bones. Further, bone marrow vascular niches supporting stem cells are often complex microenvironments involving multiple different cell populations and vessel subtypes. This review provides an overview of the emerging vascular cell heterogeneity in bone and the new roles of the bone vasculature and associated vascular niches in health and disease.

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Section: Angiogenesis and Vascularization In Bone Tissue Engineeringmentioning

confidence: 99%

Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

Chen

Hendriks

Chatzis

et al. 2020

Journal of Bone and Mineral Research

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“…PLGA has been used in locally implanted medical devices, including scaffolds for controlled drug release and to enhance drug bioavailability in tissue repairing processes [ 15 ]. The studies conducted have achieved the impregnation of gemcitabine in PLGA foams from ethyl lactate solutions of gemcitabine [ 16 ], mesoporous bioactive glass particles (MBGs) have been incorporated into PLGA [ 17 ], PLGA composite foams were produced using phosphate glass particles as filler [ 18 ], thymol has been impregnated into PLGA for controlled release [ 19 ] and bioactive lipids have been incorporated to PLGA scaffolds [ 20 ]. In some cases, such as bone tissue repair, the action of the drug is to be prolonged for as long as months.…”

Section: Introductionmentioning

confidence: 99%

Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment

et al. 2021

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Poly(D,L,-lactide-co-glycolide) (PLGA) foam samples impregnated with rutin were successfully produced by supercritical foaming processes. A number of parameters such as pressure (80–200 bar), temperature (35–55 °C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of the poly(D,L,-lactide-co-glycolide) (50:50 and 75:25) were studied to determine their effect on the expansion factor and on the glass transition temperature of the polymer foams and their consequences on the release profile of the rutin entrapped in them. The impregnated foams were characterized by scanning electron microscopy, differential scanning calorimetry, and mercury intrusion porosimetry. A greater impregnation of rutin into the polymer foam pores was observed as pressure was increased. The release of rutin in a phosphate buffer solution was investigated. The controlled release tests confirmed that the modification of certain variables would result in considerable differences in the drug release profiles. Thus, five-day drug release periods were achieved under high pressure and temperature while the depressurization rate remained low.

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“…Many synthetic thermoplastic aliphatic polymers, such as polylactide (PLA), polyglycolide (PGA), poly(3-caprolactone) (PCL), and poly(lactide-co-glycolide) (PLGA), have been commonly used to fabricate tissue engineering scaffolds because of their excellent biodegradability and biocompatibility. [18][19][20] PCL, a semi-crystalline polymer, has been a popular biomedical material for tissue engineering. PCL has good mechanical properties such as high exibility and elongation.…”

Section: Introductionmentioning

confidence: 99%