Supercritical fluid extraction of grape seed: Process scale-up, extract chemical composition and economic evaluation

Prado, Juliana M.; Dalmolin, Irede Angela Lucini; Carareto, Natália D.D.; Basso, Rodrigo Corrêa; Meirelles, Antônio José de Almeida; Oliveira, J. Vladimir; Batista, Eduardo Augusto Caldas; Meireles, M. Ângela A.

doi:10.1016/j.jfoodeng.2011.10.007

Cited by 178 publications

(101 citation statements)

References 29 publications

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“…Although the COM is a direct function of temperature and pressure, mainly due to energy costs, the extraction yield was the factor that exhibited the most influence, causing a significant decrease in COM. Similar observations were reported in previous studies (Albuquerque & Meireles, 2012;Prado et al, 2010;Prado et al, 2012). cC a-c Values followed by different letters at the same column for each economic parameter indicate significant differences between the extraction vessel capacity, according to Tukey Test (p<0.05).…”

Section: Cost Of Manufacturing (Com)supporting

confidence: 88%

Supercritical Carbon Dioxide Extraction of Polyphenols from Pomegranate (Punica granatum L.) Leaves: Chemical Composition, Economic Evaluation and Chemometric Approach

Cavalcanti

Navarro-Díaz

Santos

et al. 2012

JFR

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The increasing demand for high-quality products and economically and environmentally friendly technologies, as well as restrictive legislative actions, has stimulated scientific research on the extraction, purification and identification of bioactive compounds from natural sources. Pomegranate (Punica granatum L.) is commonly used in traditional medicine due to its pharmacological properties, such as its anti-inflammatory, antihepatotoxicity, anti-lipoperoxidation, antidiabetic, anti-cancer and antimicrobial activities. The use of industrial residues as sources of bioactive compounds has emerged as an economically viable solution to the problem of solid waste treatment. In this context, this work aimed to evaluate the SC-CO 2 extraction of polyphenols from pomegranate leaves, evaluating the influence of temperature (40 and 50°C) and pressure (10-30 MPa) on extraction yield (EY), total phenolic content (TPC), antioxidant activity (AA) and the cost of manufacturing (COM) of the extracts. Principal component analysis (PCA) was used to reduce the dimensionality of multivariate data, making the visualization more straightforward and manageable. A high EY and TPC and low COM were obtained at the most effective operational conditions of 50°C and 30 MPa. The lack of correlation between EY-AA and TPC-AA indicated the coextraction of non-phenolic compounds. This assumption was corroborated by GC-MS analysis, which showed high levels of eicosanol, squalene, linoleic acid and tocols. Even though SC-CO 2 extraction resulted in a high TPC (257-389 mg.g -1 ) compared to the literature data, the low EY (0.21-0.67 %) and non-phenolic presence suggest that SC-CO 2 extraction may be a good purification pretreatment for the removal of non-polyphenolic compounds prior to further polyphenol extraction.

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Section: Cost Of Manufacturing (Com)supporting

confidence: 88%

Supercritical Carbon Dioxide Extraction of Polyphenols from Pomegranate (Punica granatum L.) Leaves: Chemical Composition, Economic Evaluation and Chemometric Approach

Cavalcanti

Navarro-Díaz

Santos

et al. 2012

JFR

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“…All experiments were carried out in dynamic operation mode and the final extract corresponded to separator discharge. Subsequently, the test that yielded the highest and operation limits of the equipment at pilot scale were considered to scale up the system maintaining the relation between CO 2 flow and mass of raw material constant (Mezzomo et al, 2009;Prado et al, 2012). The overall extraction curve to this scale was done in duplicate using 6.050 g of milled almonds at a temperature of 60 °C, pressure of 450 bars and CO 2 flow of 1270 g/min.…”

Section: Methodsmentioning

confidence: 99%

“…Subsequently, the process of Sacha inchi oil extraction was scaled up to a volume of 12 L keeping the ratio between CO 2 flow and raw material mass constant (Mezzomo et al, 2009;Prado et al, 2012), using the extraction conditions of the 500P.40F.180t oil that had the highest recovery and its acidity was inferior to the limit to which the oil is rejected. For scaling, the temperature was kept constant, pressure was adjusted to the upper limit of operation of the equipment (450 bars), and CO 2 flow was determined with a value of 1270 g/min through the ratio described.…”

Section: Sacha Inchi Oil Extractionmentioning

confidence: 99%

Supercritical CO<sub>2</sub> extraction of oil and omega-3 concentrate from Sacha inchi (<em>Plukenetia volubilis</em> L.) from Antioquia, Colombia

2017

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SUMMARY:Sacha inchi (Plukenetia volubilis L.) seeds were employed for oil extraction with supercritical CO 2 at laboratory scale. The supercritical extraction was carried out at a temperature of 60 °C, pressure range of 400-500 bars and CO 2 flow of 40-80 g/min. The maximum recovery was 58% in 180 min, favored by increasing the residence time of CO 2 in the extraction tank. Subsequently, the process was evaluated at pilot scale reaching a maximum recovery of 60% in 105 min, with a temperature of 60 °C, pressure of 450 bars and CO 2 flow of 1270 g/min. The fatty acid composition of the oil was not affected for an extraction period of 30-120 min. The Sacha inchi oil was fractionated with supercritical CO 2 to obtain an omega-3 concentrate oil without finding a considerable increase in the proportion of this compound, due to the narrow range in the carbon number of fatty acids present in the oil (16-18 carbons), making it difficult for selective separation. KEYWORDS: a -linolenic acid; Omega-3; Sacha inchi; Supercritical extractionRESUMEN: Extracción con CO 2 supercrítico de aceite y un concentrado de omega-3 a partir de Sacha inchi (Plukenetia volubilis L.) proveniente de Antioquia, Colombia. Semillas de Sacha inchi fueron empleadas para la extracción de su aceite con CO 2 supercrítico a escala de laboratorio, a una temperatura de 60 °C, entre 400-500 bares de presión y un flujo de CO 2 entre 40-80 g/min, obteniendose una recuperación máxima del 58% en 180 min favorecida por el aumento en el tiempo de residencia del CO 2 en el tanque de extracción. Posteriormente, se evaluó el proceso a escala piloto, alcanzando una recuperación máxima del 60% en 105 min de extracción, a una temperatura de 60 °C, presión de 450 bares y flujo de CO 2 de 1270 g/min, sin afectar la composición de los ácidos grasos del aceite durante un periodo de extracción entre 30-120 min. El aceite de Sacha inchi fue fraccionado con CO 2 supercrítico para la obtención de un aceite concentrado de omega-3, sin encontrar aumento considerable en la proporción de este compuesto debido al estrecho rango en el número de carbonos (16-18 carbonos) de los ácidos grasos presentes en el aceite, lo que dificulta su separación selectiva.

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“…Many of them have simulated the manufacturing cost (MC) of extracts, mostly obtained by supercritical fluid extraction from vegetal raw materials and have reported the financial viability of the process such as antioxidant extracts from Myrciaria cauliflor (Cavalvanti et al, 2013), alkylamides from Spilanthes (Veggi et al, 2014), production of phenolic rich extracts and extraction of carotenoids from Brazilian plants (Prado et al, 2010;Prado et al, 2012). Supercritical fluid extraction is associated with high investment costs (Rosa and Meireles, 2005) and according to Patel et al (2006) the solute extracted using supercritical carbon dioxide is significantly different from their conventional equivalents and energy costs in this process are lower than those incurred in steam distillation and solvent extraction.…”

Section: Economic Evaluationmentioning

confidence: 99%

“…This simulator has been used by other authors to simulate supercritical fluid extraction processes using different raw materials (Prado, 2009;Prado et al, 2009;Prado et al, 2012;Delgado and Pessoa, 2014). The simulator used to estimate the manufacturing cost (MC) utilizing the methods based on Peters & Timmerhaus (1991) and Turton et al (2008).…”

Section: Economic Evaluationmentioning

confidence: 99%

Technical and Economic Evaluation of Phorbol Esters Extraction from Jatropha Curcas Seed Cake using Supercritical Carbon Dioxide

Pereira¹,

Pessoa²,

Mendonça³

et al. 2016

AJBB

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Jatropha curcas plant shrub of Euphorbiaceae family is a plant whose seeds are rich in oil that can be used for biofuel production. However the seeds contain many toxic compounds which the most important ones are known as phorbol esters (PEs). This study has as aim the study of the technical and economic feasibility of the supercritical fluid to extract the PEs present in the Jatropha seed cake. The effect of temperature (40 -100 ºC) and pressure (100 -500 bar) on the phorbol yield was investigated using a central composite design methodology to determine the significance and interactions of these parameters. PEs in the extracted samples were analyzed and quantified by HPLC. The supercritical fluid extraction was effective in the PE extraction from Jatropha curcas cake varying from 23.0%, at 70 ºC and 500 bar to 2.6% at 90 ºC and 160 bar. The results showed that pressure had the most significant enhancing effect on the phorbol ester yield. Simulations of phorbol ester extraction from Jatropha curcas cake were carried out using SuperPro Designer 9.0 to evaluate the production costs of an industrial process to treat the necessary quantity of cake. It was possible to conclude that the supercritical extraction is a promising technology that can be applied to detoxify the Jatropha curcas cake.

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Supercritical fluid extraction of grape seed: Process scale-up, extract chemical composition and economic evaluation

Cited by 178 publications

References 29 publications

Supercritical Carbon Dioxide Extraction of Polyphenols from Pomegranate (Punica granatum L.) Leaves: Chemical Composition, Economic Evaluation and Chemometric Approach

Supercritical Carbon Dioxide Extraction of Polyphenols from Pomegranate (Punica granatum L.) Leaves: Chemical Composition, Economic Evaluation and Chemometric Approach

Supercritical CO<sub>2</sub> extraction of oil and omega-3 concentrate from Sacha inchi (<em>Plukenetia volubilis</em> L.) from Antioquia, Colombia

Technical and Economic Evaluation of Phorbol Esters Extraction from Jatropha Curcas Seed Cake using Supercritical Carbon Dioxide

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