Supercritical fluid technology parameters affecting size and behavior of stereocomplex polylactide particles and their composites

Im, Seung Hyuk; Lee, Cheol Woo; Bibi, Gulnaz; Jung, Youngmee; Kim, Soo Hyun

doi:10.1002/pen.24681

Cited by 14 publications

(12 citation statements)

References 30 publications

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“…Ultimately, this change in a biodegradable polymer can result in an increase in thermal stability, mechanical strength, resistance against solvent penetration, and external forces. Stereocomplex crystals in PLA have commonly been formed by solution blending, melt blending, emulsion blending, precipitation into non-solvent, and supercritical fluid (SCF) techniques [ 4 , 5 , 6 , 7 , 8 , 9 ]. Each method has different advantages and disadvantages regarding the yield and stereocomplexation efficiency, processability, solubility, time, and cost.…”

Section: Introductionmentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

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Section: Introductionmentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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“…In recent years, the researches on the SC-PLA have achieved significant progress. Except for solution and melt blending methods, it has also been reported that the supercritical fluid method and solid-state copolymerization method are also new preparation ways to synthesize SC-PLA [26,27]. Nevertheless, more efforts should be dedicated to further enhance the synthesis of SC-PLA structure as well as discussing their web structures and potential applications.…”

Section: Introductionmentioning

confidence: 99%

Bicomponent PLA Nanofiber Nonwovens as Highly Efficient Filtration Media for Particulate Pollutants and Pathogens

et al. 2021

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Herein, a novel form of bicomponent nanofiber membrane containing stereo-complex polylactic acid (SC-PLA) was successfully produced by the side-by-side electrospinning of Poly (L-lactic acid) (PLLA) and Poly (D-lactic acid) (PDLA). We demonstrate that through these environmentally sustainable materials, highly efficient nanofiber assemblies for filtration can be constructed at very low basis weight. The physical and morphological structure, crystalline structure, hydrophobicity, porous structure, and filtration performance of the fibrous membranes were thoroughly characterized. It was shown that the fabricated polylactic acid (PLA) side-by-side fiber membrane had the advantages of excellent hydrophobicity, small average pore size, high porosity, high filtration efficiency, low pressure drop as well as superior air permeability. At the very low basis weight of 1.1 g/m2, the filtration efficiency and pressure drop of the prepared side-by-side membrane reached 96.2% and 30 Pa, respectively. Overall, this biomass-based, biodegradable filtration material has the potential to replace the fossil fuel-based polypropylene commercial meltblown materials for the design and development in filtration, separation, biomedical, personal protection and other fields.

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“…The concept of simultaneous casting and selective dissolution of HCs can be extended to a layer-by-layer casting approach ( Figure 2C ) through alternative deposition of PLLA and PDLA homopolymers onto the substrate using inkjet printing technique for achieving a predominant SC formation (Mei et al, 2018 ; Xie et al, 2018 ). Hang et al deomonstrate that the thermal decomposition temperature of PLA-SC formed via this inkjet printing approach shows an increase of more than 90°C compared with original PLA without inclusion of SCs (Im et al, 2018 ). The layer-by-layer deposition process is suitable for manufacturing three-dimensional polymer composites with a customizable material shape.…”

Section: Solution Castingmentioning

confidence: 99%

Recent Progress in Enhancing Poly(Lactic Acid) Stereocomplex Formation for Material Property Improvement

et al. 2020

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The production and utilization of polymers have been widely implemented into diverse applications that benefit modern human society, but one of the most valuable properties of polymers, durability, has posed a long-standing environmental challenge from its inception since plastic waste can lead to significant contamination and remains in landfills and oceans for at least hundreds of years. Poly(lactic acid) (PLA) derived from renewable resources provides a sustainable alternative to traditional polymers due to its advantages of comparable mechanical properties with common plastics and biodegradability. However, the poor thermal and hydrolytic stability of PLA-based materials limit their potential for durable applications. Stereocomplex crystallization of enantiomeric poly (l-lactide) (PLLA) and poly (d-lactide) (PDLA) provides a robust approach to significantly enhance material properties such as stability and biocompatibility through strong intermolecular interactions between L-lactyl and D-lactyl units, which has been the key strategy to further PLA applications. This review focuses on discussing recent progress in the development of processing strategies for enhancing the formation of stereocomplexes within PLA materials, including thermal processing, additive manufacturing, and solution casting. The mechanism for enhancing SC formation and resulting material property improvement enabled by each method are also discussed. Finally, we also provide the perspectives on current challenges and opportunities for improving the understanding of processing-structure-property relationship in PLA materials that could be beneficial to their wide practical applications for a sustainable society.

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Supercritical fluid technology parameters affecting size and behavior of stereocomplex polylactide particles and their composites

Cited by 14 publications

References 30 publications

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Bicomponent PLA Nanofiber Nonwovens as Highly Efficient Filtration Media for Particulate Pollutants and Pathogens

Recent Progress in Enhancing Poly(Lactic Acid) Stereocomplex Formation for Material Property Improvement

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