Supercritical fluids applications in nanomedicine

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

“…A possible explanation of these results is that probably FA in the mixture operates as a surface tension reducer and, thus, favors the mechanism of gas-mixing with respect to jet break-up, reducing the time of surface tension vanishing [52]. It is also interesting to note that using DMSO at 150 bar, 40°C, nanoparticles have been frequently observed in the literature for several solutes [36,53], with the exception of PVP [47].…”

Efficient encapsulation of proteins in submicro liposomes using a supercritical fluid assisted continuous process

“…In the field, of particles formation and carriers production, supercritical fluid technologies have been proposed to overcome several limitations of conventional processes, such as the control of particle size at micrometric and nanometric level, the extensive use of organic solvents, high operating temperatures and mechanical stresses that can degrade labile compounds [13][14][15][16][17]. Recently, some techniques based on the use of supercritical CO 2 (scCO 2 ) have been proposed also for liposome preparation [18][19][20][21][22][23]; they try to take the advantage of the enhanced mass transfer of supercritical fluids [24] and can be divided in two categories: two steps processes in which the dried lipid particles need to be rehydrated [11,22,[25][26][27][28], and one step processes in which a liposome-water suspension is directly obtained at the end of the process [29][30][31].…”

A Simplified Method to Estimate Sc-CO2 Extraction of Bioactive Compounds from Different Matrices: Chili Pepper vs. Tomato By-Products

“…In 2014 there were more than 150 SFE industrial plants with a total extraction volume of more than 500 L in the world [19]. Many of these production plants are generally devoted to the SFE process involving a preliminary Sc-CO 2 extraction of natural products, leading to the recovery of high-value products which provide interesting options for their use in the nutraceutical and functional food industry [20].…”