Supercritical fluids for pharmaceutical particle engineering: Methods, basic fundamentals and modelling

Tabernero, Antonio; Valle, Eva M. Martín del; Galán, Miguel Á.

doi:10.1016/j.cep.2012.06.004

Cited by 163 publications

(97 citation statements)

References 178 publications

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“…Organic non-aqueous solvents such as dimethylsulfoxide that have been normally used in the SAS technique to enhance miscibility of solute with CO 2 at its recrystallisation temperature and pressure, however, compromised the environmental friendly nature of the CO 2 . Thus, this method may not be favourable for biomolecules processing as it may cause conformational changes to their native structure (Tabernero A. et al, 2012;Zhao Z. et al, 2015).…”

Section: Supercritical Dryingmentioning

confidence: 99%

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Saallah

Lenggoro

2018

KONA

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In the past few decades, enormous advances have been achieved in the field of particle technology and the trend has been shifted from macro to micro and recently to the nanoscale. Integration of nanotechnology and biotechnology has paved the way to the development of biological nanoparticles, derived from biomolecules, and biomolecule-nanoparticle conjugates for numerous applications. This review provides an overview of various types of biological nanoparticles and the methods of their fabrication with primary emphasis on the drying methods, particularly on the newly emerging technique, the electrospraying. Recent advances in the integration of biomolecules with nanoparticles in the past five years to present are also discussed. Finally, the application of the biomolecule-nanoparticle conjugates in various fields including medicals and pharmaceuticals, biosensors and bioelectronics, foods, and agricultures are also highlighted.

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Section: Supercritical Dryingmentioning

confidence: 99%

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Saallah

Lenggoro

2018

KONA

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“…The liquid-like density of SCF provides solvent power similar to a light hydrocarbon and its gas-like viscosity allows excellent mass transfer and higher diffusivity in a material (Shivonen et al, 1999). A number of different SCFs have been used in various applications such as organic synthesis, cleaning and materials processing [Tabernero et al, 2012;Duarte et al, 2015]. However, carbon dioxide (CO2)…”

Section: Methyl] Sulfinyl]-1h-benzimidazole)mentioning

confidence: 99%

“…In recent years, the application of supercritical fluid technology in formulation development has shown tremendous success in the field of drug delivery (Bruner, 2010;Tabernero et al, 2012). A supercritical fluid (SCF) can be defined as a substance above its critical pressure (Pc) and temperature (Tc) where it exists as a single phase and possesses properties of both liquids and gases (Knez et al, 2015).…”

Section: Methyl] Sulfinyl]-1h-benzimidazole)mentioning

confidence: 99%

Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery

Khan

Trivedi

Mitchell

et al. 2016

European Journal of Pharmaceutical Sciences

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This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w) of metolose (MET) with polyethylene glycol (PEG 400) (0.5% w/w) as plasticiser, and L-arg (0.2% w/w) as a stabilizer and dried in an oven at 40°C. The blank and drug loaded films were divided into two groups, one group was subjected to supercritical carbon dioxide (scCO2) treatment and the other group untreated. The untreated and scCO2 treated films were then characterised using differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, hydration (swelling), mucoadhesion and in vitro drug dissolution studies. Treatment of the solvent cast films with scCO2 caused significant changes to the functional and physical properties of the MET films. The original drug loaded MET films showed a sustained release of OME (1 hour), whereas scCO2 treatment of the formulations resulted in fast dissolving films with more than 90% drug release within 15 minutes.

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“…Po przekroczeniu tego punktu zanika granica faz między stanem ciekłym i gazowym, a powstała jedna faza wykazuje właściwości pośrednie pomiędzy właściwościami cieczy i gazu. Wysoka ściśliwość płynów nadkrytycznych powoduje, poprzez zmiany temperatury i ciśnienia, że łatwo można sterować ich gęstością i zdolnością rozpuszczania substancji, co umożliwia frakcjonowanie rozpuszczalnych w tych płynach substancji [8,25]. Dzięki właściwościom zależnym od paramentów procesowych płyny nadkrytyczne znajdują liczne zastosowania.…”

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