Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase

Wilmanns, C.; Casey, Adrian; Schinzel, H.; Walter, P

doi:10.1258/phleb.2009.009075

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…They found a significantly higher prevalence of subjects with at least one C677T MTHFR allele among those with varicose veins than among a control group (OR = 1.74; P < 0,005) [ 21 ]. This was also notedby the study of Wilmanns and colleagues [ 22 ]. We did not see any significant relation with varicose vein or MTHFR mutations.…”

Section: Discussionsupporting

confidence: 79%

Potential Risk Factors for Varicose Veins with Superficial Venous Reflux

Kapısız¹,

Kulaoğlu²,

Fen³

et al. 2014

International Journal of Vascular Medicine

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The objective of the study is to evaluate a range of potential risk factors in the etiology of varicose veins with superficial venous reflux. Forty-nine patients attending a cardiovascular surgery clinic for the management of varicose disease between 2009 and 2010 were enrolled for the study. The age range of the patient group was 44,04 ± 15,05 years and female/male (F/M) ratio was 30/19. Twenty-six normal, healthy volunteers with the age of 40,94 ± 13,60 years and with the female/male ratio of 15/11 acted as control subjects. We investigated several parameters including body mass index, age, birth number > 1, standing for a long time (standing for 8 or more hours without taking a break), systemic diseases, family history, venous Doppler fındings, the levels of homocysteine, ferritin, vitamin B12, and hemoglobin, sedimentation rate, mean corpuscular volume, low density lipoprotein, and rheumatoid factor of the patient group and the control group. We also determined the contribution of the methylene tetrahydrofolate reductase 677 C>T and 1298 A>C gene polymorphisms and FV Leiden in both groups. In this small study, there appears to be no association between varicose veins and body mass index, smoking, type 2 DM, hypertension, family history, and birth number. A history of increased standing duration period (>8 hours) and rheumatoid factor positivity have association with varicose veins with superficial venous reflux.

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Section: Discussionsupporting

confidence: 79%

Potential Risk Factors for Varicose Veins with Superficial Venous Reflux

Kapısız¹,

Kulaoğlu²,

Fen³

et al. 2014

International Journal of Vascular Medicine

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“…39 In turn, decreased DNA methylation may involve aberrant expression of structural and matrix proteins or reduced DNA integrity, resulting in premature aging of the vascular tissue. 40 This study has some potential limitations. First, it has a case-control design, which does not allow inferences on causal relationships between the MTHFR 677C>T variant and PAD, Hcy levels, or disease severity.…”

Section: Discussionmentioning

confidence: 91%

MTHFR 677C>T (rsRS1801133) variant is associated with hyperhomocysteinemia but not with clinical severity in patients with peripheral arterial disease

Silvestre,

Carrara,

Flauzino

et al. 2023

J. vasc. bras.

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Background The MTHFR 677C>T variant’s involvement with hyperhomocysteinemia and peripheral arterial disease (PAD) is still unclear. Objectives To evaluate associations between the MTHFR 677C>T (rs1801133) variant and susceptibility to and severity of PAD and homocysteine (Hcy) levels. Methods The study enrolled 157 PAD patients and 113 unrelated controls. PAD severity and anatomoradiological categories were assessed using the Fontaine classification and the Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC), respectively. The variant was genotyped using real-time polymerase chain reaction and Hcy levels were determined using chemiluminescence microparticle assay. Results The sample of PAD patients comprised 60 (38.2%) females and 97 (61.8%) males. Patients were older and had higher Hcy than controls (median age of 69 vs. 45 years, p<0.001; and 13.66 µmol/L vs. 9.91 µmol/L, p=0.020, respectively). Hcy levels and the MTHFR 677C>T variant did not differ according to Fontaine or TASC categories. However, Hcy was higher in patients with the CT+TT genotypes than in those with the CC genotype (14.60 µmol/L vs. 12.94 µmol/L, p=0.008). Moreover, patients with the TT genotype had higher Hcy than those with the CC+CT genotypes (16.40 µmol/L vs. 13.22 µmol/L, p=0.019), independently of the major confounding variables. Conclusions The T allele of MTHFR 677C>T variant was associated with higher Hcy levels in PAD patients, but not in controls, suggesting a possible interaction between the MTHFR 677C>T variant and other genetic, epigenetic, or environmental factors associated with PAD, affecting modulation of Hcy metabolism.

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“…1 a and b) of complicated and uncomplicated disease suggest different subsets of genetic origin. Thrombotic disease has been closely related to a common homozygous mutant genotype (TT) at c.677C>T, the most studied polymorphism of the MTHFR (methylenetetrahydrofolate reductase) gene ( Milio et al, 2008 , Wilmanns et al, 2011 ), coding for a key enzyme of one-carbon metabolism. The prevalence of c.677C>T accurately overlaps with geographic variations in the incidence of primary varicose veins ( Wilmanns et al, 2011 , Wilcken et al, 2003 , Raffetto, 2011 ) and has been previously linked to the occurrence of varicose veins ( Sverdlova et al, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

Morphology and Progression in Primary Varicose Vein Disorder Due to 677C>T and 1298A>C Variants of MTHFR

et al. 2015

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BackgroundClinical assessment and prognostic stratification of primary varicose veins have remained controversial and the molecular pathogenesis is unknown. Previous data have suggested a contribution of the MTHFR (methylenetetrahydrofolate reductase) polymorphism c.677C>T.MethodsWe collected blood and vein specimens from 159 consecutive patients undergoing varicose vein surgery, or autologous vein reconstruction for arterial occlusive disease as controls. We compared the frequencies of c.677C>T and another polymorphism of MTHFR, c.1298A>C, with morphology and types of complicated disease. Morphology was recorded as a trunk or perforator type and peripheral congestive complication was defined as chronic venous insufficiency (CEAP C3–6) associated with edema and skin manifestations.FindingsMultivariate analysis of genotypes for c.677C>T and c.1298A>C indicated that c.677C>T was associated significantly with the trunk phenotype (43/53 patients, 81%, p < 0.01), while c.1298A>C was associated significantly with the perforator phenotype (18/24 patients, 75%, p < 0.01) of primary varicose veins. Accordingly, when both c.677C>T and c.1298A>C displayed a heterozygous genotype, the patients were more likely to present with both phenotypes. Additionally, c.1298A>C was found to be strongly linked to the congestive complication (34/51 patients, 67%, p < 0.01).InterpretationBoth polymorphisms of MTHFR may be involved in the morphological specification of primary varicose veins and contribute to the development of complicated disease.FundingNone.

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Superficial thrombophlebitis in varicose vein disease: the particular role of methylenetetrahydrofolate reductase

Cited by 10 publications

References 17 publications

Potential Risk Factors for Varicose Veins with Superficial Venous Reflux

Potential Risk Factors for Varicose Veins with Superficial Venous Reflux

MTHFR 677C>T (rsRS1801133) variant is associated with hyperhomocysteinemia but not with clinical severity in patients with peripheral arterial disease

Morphology and Progression in Primary Varicose Vein Disorder Due to 677C>T and 1298A>C Variants of MTHFR

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