Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy

Hua, Mu-Yi; Yang, Hung-Wei; Liu, Hao-Li; Tsai, Rung-Ywan; Pang, See‐Tong; Chuang, Kun-Lung; Chang, Yu‐Sun; Hwang, Tsong‐Long; Chang, Ying-Hsu; Chuang, Heng-Chang; Chuang, Cheng-Keng

doi:10.1016/j.biomaterials.2011.08.014

Cited by 82 publications

(57 citation statements)

References 48 publications

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“…Super-hi-magnetization nanocarriers produced with a highly magnetic Fe 3 O 4 core and a poly-[N-(1-butyric acid)]aniline shell have also been used to tackle P-gp-mediated MDR (Hua et al, 2011). The Fe 3 O 4 core acted as a contrast agent to enable tracking of the nanocarriers using magnetic resonance imaging techniques.…”

Section: Novel Strategies To Inhibit P-glycoproteinmentioning

confidence: 99%

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

2014

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P-glycoprotein (P-gp) is a key player in the multidrug-resistant phenotype in cancer. The protein confers resistance by mediating the ATP-dependent efflux of an astonishing array of anticancer drugs. Its broad specificity has been the subject of numerous attempts to inhibit the protein and restore the efficacy of anticancer drugs. The general strategy has been to develop compounds that either compete with anticancer drugs for transport or act as direct inhibitors of P-gp. Despite considerable in vitro success, there are no compounds currently available to "block" P-gp-mediated resistance in the clinic. The failure may be attributed to toxicity, adverse drug interaction, and numerous pharmacokinetic issues. This review provides a description of several alternative approaches to overcome the activity of P-gp in drug-resistant cells. These include 1) drugs that specifically target resistant cells, 2) novel nanotechnologies to provide high-dose, targeted delivery of anticancer drugs, 3) compounds that interfere with nongenomic transfer of resistance, and 4) approaches to reduce the expression of P-gp within tumors. Such approaches have been developed through the pursuit of greater understanding of resistance mediators such as P-gp, and they show considerable potential for further application.

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Section: Novel Strategies To Inhibit P-glycoproteinmentioning

confidence: 99%

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

2014

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“…[6][7][8][9][10][11] Compared with these nanoscale carriers, polymeric micelles self-assembled from amphiphilic polymers have captured increasing attention. [12][13][14] Polymeric micelles used as hydrophobic anticancer drug carriers have been proved to have a multitude of advantages, such as a convenient synthesis, high drug loading capacity and biocompatibility, low cytotoxicity, efficient drug delivery, and controlled release.…”

mentioning

confidence: 99%

pH-sensitive micelles self-assembled from polymer brush (PAE-g-cholesterol)-b-PEG-b-(PAE-g-cholesterol) for anticancer drug delivery and controlled release

Huang¹,

Liao²,

Zhang³

et al. 2017

IJN

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“…It was indicated that the SSPEI60-SPIO nanoparticle was efficient as a T2-negative contrast agent for MR imaging. The relaxivity (defined as the slope of T2 versus Fe concentration) of SSPEI60-SPIO nanoparticles was found to be 97.6 mM -1 s -1 , which is comparable to that of Resovist (95.2 mM -1 s -1 ), 32 a commercial SPIO-based contrast agent as a positive control. Further, an in vivo MR imaging study revealed that, at 1 to 3 hours post-IV injection of SSPEI60-SPIO nanoparticles in a nude mouse bearing a HepG2 tumor, the signal intensity on a T2-weighted fast spin echo image of the tumor significantly reduced ( Figure 7C), indicating accumulation of the nanoparticles in the tumor.…”

Section: 2%±31% Gfpmentioning

confidence: 71%

Theranostic nanoparticles based on bioreducible polyethylenimine-coated iron oxide for reduction-responsive gene delivery and magnetic resonance imaging

Li¹,

Tang²,

Pulli³

et al. 2014

IJN

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Theranostic nanoparticles based on superparamagnetic iron oxide (SPIO) have a great promise for tumor diagnosis and gene therapy. However, the availability of theranostic nanoparticles with efficient gene transfection and minimal toxicity remains a big challenge. In this study, we construct an intelligent SPIO-based nanoparticle comprising a SPIO inner core and a disulfide-containing polyethylenimine (SSPEI) outer layer, which is referred to as a SSPEI-SPIO nanoparticle, for redox-triggered gene release in response to an intracellular reducing environment. We reveal that SSPEI-SPIO nanoparticles are capable of binding genes to form nano-complexes and mediating a facilitated gene release in the presence of dithiothreitol (5–20 mM), thereby leading to high transfection efficiency against different cancer cells. The SSPEI-SPIO nanoparticles are also able to deliver small interfering RNA (siRNA) for the silencing of human telomerase reverse transcriptase genes in HepG2 cells, causing their apoptosis and growth inhibition. Further, the nanoparticles are applicable as T2-negative contrast agents for magnetic resonance (MR) imaging of a tumor xenografted in a nude mouse. Importantly, SSPEI-SPIO nanoparticles have relatively low cytotoxicity in vitro at a high concentration of 100 μg/mL. The results of this study demonstrate the utility of a disulfide-containing cationic polymer-decorated SPIO nanoparticle as highly potent and low-toxic theranostic nano-system for specific nucleic acid delivery inside cancer cells.

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Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy

Cited by 82 publications

References 48 publications

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?

pH-sensitive micelles self-assembled from polymer brush (PAE-<em>g</em>-cholesterol)-<em>b</em>-PEG-<em>b</em>-(PAE-<em>g</em>-cholesterol) for anticancer drug delivery and controlled release

Theranostic nanoparticles based on bioreducible polyethylenimine-coated iron oxide for reduction-responsive gene delivery and magnetic resonance imaging

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