Superhydrophobic coating of elastomer on different substrates using a liquid template to construct a biocompatible and antibacterial surface

Wei, Ye; Shi, Qiang; Hou, Jingguo; Jin, Jing; Fan, Qun Bo; Wong, Shing‐Chung; Xu, Xiaodong; Yin, Jinghua

doi:10.1039/c4tb01126k

Cited by 31 publications

(21 citation statements)

References 27 publications

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“…Therefore, using biomaterial surfaces that resist bacteria attachment is an intuitive solution to this problem. 54 Super-hydrophobic polymer surfaces, such as very smooth silicone, polyurethane, polytetrafluoroethylene (PTFE), poly(vinyl chloride) (PVC), and polyethylene (PE), that have water contact angles larger than 150°, low surface energy, 55,56 as well as unique water repellent 57 and self-cleaning abilities, 56 are known to have resistance to microbial cell adhesion during short-term applications. 58 Hydrophilic surface modifications, such as the PEG modified surfaces discussed above, have also been widely characterized in the literature and have demonstrated excellent anti-adhesive properties for bacteria cells and proteins.…”

Section: Current Strategies For Creating Antibacterial Surfacesmentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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Biomedical devices are essential for patient diagnosis and treatment; however, when blood comes in contact with foreign surfaces or homeostasis is disrupted, complications including thrombus formation and bacterial infections can interrupt device functionality, causing false readings and/or shorten device lifetime. Here, we review some of the current approaches for developing antithrombotic and antibacterial materials for biomedical applications. Special emphasis is given to materials that release or generate low levels of nitric oxide (NO). Nitric oxide is an endogenous gas molecule that can inhibit platelet activation as well as bacterial proliferation and adhesion. Various NO delivery vehicles have been developed to improve NO’s therapeutic potential. In this review, we provide a summary of the NO releasing and NO generating polymeric materials developed to date, with a focus on the chemistry of different NO donors, the polymer preparation processes, and in vitro and in vivo applications of the two most promising types of NO donors studied thus far, N-diazeniumdiolates (NONOates) and S-nitrosothiols (RSNOs).

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Section: Current Strategies For Creating Antibacterial Surfacesmentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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“…4b in the tabulated form can be found in the ESI. 37 To account for the difference in hemolysis rates between regular and near-superhydrophobic surfaces, the mechanical force acting on the blood ow, which is a well-known source of hemolysis, 7,8,11 was examined. It had also been shown previously 36 that DH is proportional to t 0.785 , and it can be observed that the data points t closely to this trend, indicated as dashed lines (near-superhydrophobic surface) and solid lines (PVC surface) in Fig.…”

Section: Hemolysismentioning

confidence: 99%

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

et al. 2016

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The use of an external mechanical pump to sustain the circulation in a body, also known as extracorporeal circulation, is an integral part of many medical procedures such as hemodialysis and cardio-pulmonary bypass. However, the damage to red blood cells caused by the flow-induced shear stresses in the flow circuit has remained an intractable problem for many years, limiting the operational duration of extracorporeal circulation. In this study, near-superhydrophobic surfaces were investigated as a potential solution to mitigate the hemolysis of blood during extracorporeal pumping through the use of a proofof-concept flow circuit. It was found that the thin layer of air trapped by the near-superhydrophobic surface due to the Cassie-Baxter state reduced the wall shear stress exerted on the blood flow, resulting in a corresponding decrease in the rate of hemolysis. For blood that undergoes an oscillatory flow, this reduction in the hemolysis was shown to be directly related to the mean shear rate and shear rate amplitude of the flow.

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“…The blood clotting time indexes (BCIs) on these surfaces had increased up to four times as compared to the corresponding BCIs on the pristine SEBS elastomer. They also showed good biocompatibility, the hemolysis ratio on the SEBS superhydrophobic coatings being up to eight-fold lower than that on the surface of the commercial SEBS elastomer [146].…”

Section: Biomimetic Hierarchical Micro-and Nanostructured Superhydropmentioning

confidence: 99%

“…Ye et al [146] developed a new bottom-up approach to the fabrication of superhydrophobic surfaces by casting a solution of an elastomer, styrene-b-(ethylene-co-butylene)-b-styrene (SEBS), on different substrates (glass, polymer, metal) followed by evaporation of the solvent. Unlike most polymers used to fabricate superhydrophobic surfaces by casting methods, which are crystalline or plastic at room temperature, elastomers are amorphous and soft, comparatively presenting a much looser packing and consequently increased mobility of the polymer chains.…”

Section: Biomimetic Hierarchical Micro-and Nanostructured Superhydropmentioning

confidence: 99%

Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part I: Molecular Basis of Biofilm Recalcitrance. Passive Anti-Biofouling Nanocoatings

Balaure

Grumezescu

2020

Nanomaterials

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Medical device-associated infections are becoming a leading cause of morbidity and mortality worldwide, prompting researchers to find new, more effective ways to control the bacterial colonisation of surfaces and biofilm development. Bacteria in biofilms exhibit a set of “emergent properties”, meaning those properties that are not predictable from the study of free-living bacterial cells. The social coordinated behaviour in the biofilm lifestyle involves intricate signaling pathways and molecular mechanisms underlying the gain in resistance and tolerance (recalcitrance) towards antimicrobial agents as compared to free-floating bacteria. Nanotechnology provides powerful tools to disrupt the processes responsible for recalcitrance development in all stages of the biofilm life cycle. The present paper is a state-of-the-art review of the surface nanoengineering strategies currently used to design antibiofilm coatings. The review is structurally organised in two parts according to the targeted biofilm life cycle stages and molecular mechanisms intervening in recalcitrance development. Therefore, in the present first part, we begin with a presentation of the current knowledge of the molecular mechanisms responsible for increased recalcitrance that have to be disrupted. Further, we deal with passive surface nanoengineering strategies that aim to prevent bacterial cells from settling onto a biotic or abiotic surface. Both “fouling-resistant” and “fouling release” strategies are addressed as well as their synergic combination in a single unique nanoplatform.

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Superhydrophobic coating of elastomer on different substrates using a liquid template to construct a biocompatible and antibacterial surface

Abstract: Elastomers were cast with a liquid template to create superhydrophobic, biocompatible, antifouling and antibacterial surfaces on virtually any substrate.

Cited by 31 publications

References 27 publications

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

A near-superhydrophobic surface reduces hemolysis of blood flow in tubes

Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part I: Molecular Basis of Biofilm Recalcitrance. Passive Anti-Biofouling Nanocoatings

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