Superior anti-infective potential of eugenol–casein nanoparticles combined with polyethylene glycol against <i>Colletotrichum musae</i> infections

Hao, Xueyan; Han, Shuxin; Qin, Dingkui; Zhang, Ya Hui; Jin, Peng; Du, Qizhen

doi:10.1039/d0ra09283e

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…This caused water molecules to detach from the surface of CSg-PEG and increased hydrophobic and hydrogen-bonding interactions between CS-g-PEG chains. As a result, gels were formed (Hao et al 2021).…”

Section: Polymer Grafting Polysaccharidementioning

confidence: 99%

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Sun,

Jiang

et al. 2024

BioRes

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In recent years, thermosensitive polysaccharide-based injectable hydrogels have gained increasing attention in biomedical applications, including wound healing, drug delivery, and cartilage repair. These hydrogels have favorable biocompatibility, biodegradability, and tunable physical and chemical properties. Thermosensitive polysaccharide-based injectable hydrogels are a class of intelligent soft matter material. They can undergo a reversible liquid-solid transition when exposed to temperature stimuli. Therefore, their precursor solutions can be accurately inserted into target sites with irregular geometries in a minimally invasive way and then transformed into gels in situ by the organism’s temperature stimulation to deliver biologically active molecules. This review summarizes the recent developments of thermosensitive injectable polysaccharide-based hydrogels. The focus is on the mechanism of sol-gel phase transition, as well as the design and preparation of thermosensitive polysaccharides and their applications in biomedical fields. In addition, the outlook of the challenges in biomedical applications is provided at the end of the paper.

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Section: Polymer Grafting Polysaccharidementioning

confidence: 99%

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Sun,

Jiang

et al. 2024

BioRes

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“…Recently, some new polymer materials, such as polyethylene glycol [ 6 ], chitosan [ 7 , 8 ], mannans [ 9 ], and hyaluronic acid [ 10 , 11 ], have been widely used as the block copolymer to coat and modify the surface of NPs. These nanocomplexes with block copolymer modifications have higher stability and bioavailability of hydrophobic drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan Oligosaccharides-Coated Paclitaxel-Casein Nanoparticles with Enhanced Stability and Antitumor Activity

et al. 2022

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This study aims to develop specific-molecular-weight hyaluronic acid oligosaccharides-coated paclitaxel-loaded casein nanoparticles (HA-PT-Cas NPs) via chemical conjugation to increase the stability and antitumor effects. Optimized HA-PT-Cas NPs (HA/casein of 3:1) were obtained with a mean size of 235.3 nm and entrapment efficiency of 93.1%. HA-PT-Cas exhibited satisfactory stability at 4 °C for 12 days and 37 °C for 3 h; paclitaxel was retained at rates of 81.4% and 64.7%, respectively, significantly higher than those of PT-Cas (only 27.8% at 4 °C after 16 h and 20.3% at 37 °C after 3 h). HA-PT-Cas exhibited high efficiency (61.3%) in inhibiting A375 tumor owing to the enhanced stability of HA oligosaccharides barrier, which was comparable with that of 10 μg/mL cis-platinum (64.9%). Mice experiments showed the 74.6% tumor inhibition of HA-PT-Cas by intravenously administration, significantly higher than that of PT-casein (39.8%). Therefore, this work provides an effective carrier for drug delivery via HA oligomers-coated modification.

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Synergistic effect of “methyl cellulose-dextran” on oral curcumin delivery via casein nanomicelle: fabrication, characterization, and cancer therapeutic efficacy assessment

Aboushoushah,

Abaza,

Elbialy

et al. 2024

Cellulose

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Superior anti-infective potential of eugenol–casein nanoparticles combined with polyethylene glycol against Colletotrichum musae infections

Abstract: The aim of this study was to improve the stability of eugenol–casein nanoparticles (EL–CS-NPs) through polyethylene glycol (PEG) modification.

Cited by 5 publications

References 34 publications

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Thermosensitive injectable polysaccharide-based hydrogels: Gelation mechanisms, synthetic strategies, biomedical applications, and challenges

Hyaluronan Oligosaccharides-Coated Paclitaxel-Casein Nanoparticles with Enhanced Stability and Antitumor Activity

Synergistic effect of “methyl cellulose-dextran” on oral curcumin delivery via casein nanomicelle: fabrication, characterization, and cancer therapeutic efficacy assessment

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